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Symptomatic diffuse submucosal intestinal lipomatosis is a rare entity. Also few cases of epidermal inclusion cyst of caecum have been reported in literature. Here, we are presenting a rare case of intestinal submucosal lipomatosis with coincidence of epidermal inclusion cyst of caecum and presumptively diagnosed as carcinoma of ileocaecal region during surgery in a 55 years old male. Both are rare entity considering the location even they should be kept as a differential diagnosis in unusual cases of intestinal perforations with inconclusive radiological findings or clinical uncertainity.

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Pilomyxoid astrocytoma (PMA) is a recently described brain tumor. PMA shares similar features with pilocytic astrocytoma (PA), the most common central nervous system (CNS) tumor in the pediatric population, yet displays subtle histologic differences. We describe a case of PMA in a six-year-old male involving sellar and suprasellar region presenting with failure to thrive and delayed developmental milestones. The histological findings revealed a tumor composed of a monotonous population of loosely arranged cells with delicate piloid like processes, within a prominent myxoid background. The tumor lacked biphasic appearance, Rosenthal fibers, eosinophilic granular bodies and calcification that are commonly observed in classical PA. Previous studies have shown PMA to behave more aggressively than PA, with shorter progression-free survival as well as a higher rate of recurrence and CNS dissemination. Thus, recognition of PMA and its distinction from classical PA is very important.

BACKGROUND: There is limited data on the spectrum of benign and malignant neoplasms of skin and subcutis in India. AIM: This study was undertaken in a tertiary care hospital of Uttarakhand to evaluate the frequency of various neoplasms affecting skin and subcutis in biopsy specimens. MATERIAL AND METHODS: A retrospective and prospective analysis of 660 skin biopsies was undertaken. The neoplasms were categorized as per International classification of World health Organization (WHO). RESULTS: Of all the skin biopsies analyzed, tumors were seen in 24.5% (162/660). Benign neoplasms were more frequently seen (72.8 %) than malignant neoplasms (27.2%). Benign to malignant ratio was 2.7:1. Amongst the benign neoplasms, soft tissue tumors including vascular, fibrous/ fibrohistiocytic, lipomatous and neural tumors constituted the largest group (61.2%) followed by appendageal tumors (22.0%), melanocytic naevi (12.3%) and keratinocytic tumors (5.1%). On the other hand, amongst the malignant neoplasms, keratinocytic tumors were the commonest (77.3%) followed by melanoma (9.1%) and appendageal tumors (9.1%). CONCLUSION: Soft tissue tumors of skin and subcutis form the largest group amongst the benign neoplasms and keratinocytic tumors are the commonest malignant skin tumors.

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