“…Regional alterations in CBF have been found to be associated with brain development (Hagstadius and Risberg, 1989; Martin et al, 1991; Takahashi et al, 2005) and several central nervous system diseases, including dementia (Chao et al, 2010; Schuff et al, 2009), mild cognitive impairment (Luckhaus et al, 2008; Park et al, 2012), multiple sclerosis (Marshall et al, 2016; Ota et al, 2013), schizophrenia (Ota et al, 2014; Ragland et al, 2001), depression (Colloby et al, 2012; Wang et al, 2014), epilepsy (Appel et al, 2012; Touchon et al, 1986), and others (Alsop et al, 2000; Devet al, 2015; Du et al, 2006; Melzer et al, 2011). However, high-quality, HR MR imaging of CBF is challenging, especially in a clinical setting.…”