Spatially adaptive unsupervised multispectral nonlocal filtering for improved cerebral blood flow mapping using arterial spin labeling magnetic resonance imaging

Bouhrara, Mustapha; Lee, Diana Y.; Rejimon, Abinand C.; Bergeron, Christopher M.; Spencer, Richard G.

doi:10.1016/j.jneumeth.2018.08.018

Cited by 12 publications

(9 citation statements)

References 56 publications

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“… 29 Finally, a whole-brain CBF map was generated from the pCASL data set using the NESMA-ASL analysis to improve accuracy and precision in CBF determination. 24 28 …”

Section: Methodsmentioning

confidence: 99%

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Association of cerebral blood flow with myelin content in cognitively unimpaired adults

et al. 2020

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BackgroundMyelin loss and cerebral blood flow (CBF) decline are central features of several neurodegenerative diseases. Myelin maintenance through oligodendrocyte metabolism is an energy-demanding process, so that myelin homeostasis is particularly sensitive to hypoxia, hypoperfusion or ischaemia. However, in spite of its central importance, little is known about the association between blood supply and myelin integrity.ObjectiveTo assess associations between cortical and subcortical CBF, and subcortical myelin content, in critical brain white matter regions.Materials and methodsMRI was performed on a cohort of 67 cognitively unimpaired adults. Using advanced MRI methodology, we measured whole-brain longitudinal and transverse relaxation rates (R1 and R2), sensitive but non-specific markers of myelin content, and myelin water fraction (MWF), a direct surrogate of myelin content, as well as regional CBF, from each of these participants.ResultsAll quantitative relaxometry metrics were positively associated with CBF in all brain regions evaluated. These associations between MWF or R1 and CBF, and, to a lesser extent, between R2 and CBF, were statistically significant in most brain regions examined, indicating that lower regional cortical or subcortical CBF corresponds to a decrease in local subcortical myelin content. Finally, all relaxometry metrics exhibited a quadratic, inverted U-shaped, association with age; this is attributed to the development of myelination from young to middle age, followed by progressive loss of myelin in later years.ConclusionsIn this first study examining the association between local blood supply and myelin integrity, we found that myelin content declines with CBF across a wide age range of cognitively normal subjects.

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“… 29 Finally, a whole-brain CBF map was generated from the pCASL data set using the NESMA-ASL analysis to improve accuracy and precision in CBF determination. 24 28 …”

Section: Methodsmentioning

confidence: 99%

“…CBF was measured using the nonlocal estimation of multispectral magnitudes (NESMA)-ASL analysis for accurate and precise CBF determination. 24 Our goal is to characterise the regional associations between cortical or subcortical CBF and local myelination variations in critical white matter regions.…”

Section: Introductionmentioning

confidence: 99%

Association of cerebral blood flow with myelin content in cognitively unimpaired adults

et al. 2020

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“…The total acquisition time was ~12 minutes. Other details of this protocol can be found in the literature 24 . A whole‐brain CBF map was then generated from the pCASL dataset using the NESMA‐ASL analysis to improve accuracy and precision in CBF determination 23,24 …”

Section: Methodsmentioning

confidence: 99%

Evidence of An Association Between Cerebral Blood Flow and Microstructural Integrity in Normative Aging Using a Holistic MRI Approach

Kiely

Triebswetter

Gong

et al. 2022

Magnetic Resonance Imaging

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BackgroundCerebral tissue integrity decline and cerebral blood flow (CBF) alteration are major aspects of motor and cognitive dysfunctions and neurodegeneration. However, little is known about the association between blood flow and brain microstructural integrity, especially in normal aging.PurposeTo assess the association between CBF and cerebral microstructural integrity.Study TypeCross sectional.PopulationA total of 94 cognitively unimpaired adults (mean age 50.7 years, age range between 22 and 88 years, 56 Men).Field Strength/SequenceA 3 T; pseudo‐continuous arterial spin labeling (pCASL), diffusion tensor imaging (DTI), Bayesian Monte Carlo analysis of multicomponent driven equilibrium steady‐state observation of T1 and T2 (BMC‐mcDESPOT).AssessmentLobar associations between CBF derived from pCASL, and longitudinal relaxation rate (R1), transverse relaxation rate (R2) and myelin water fraction (MWF) derived from BMC‐mcDESPOT, or radial diffusivity (RD), axial diffusivity (AxD), mean diffusivity (MD) and fractional anisotropy (FA) derived from DTI were assessed.Statistical TestsMultiple linear regression models were used using the mean region of interest (ROI) values for MWF, R1, R2, FA, MD, RD, or AxD as the dependent variable and CBF, age, age2, and sex as the independent variables. A two‐sided P value of <0.05 defined statistical significance.ResultsR1, R2, MWF, FA, MD, RD, and AxD parameters were associated with CBF in most of the cerebral regions evaluated. Specifically, higher CBF values were significantly associated with higher FA, MWF, R1 and R2, or lower MD, RD and AxD values.Data ConclusionThese findings suggest that cerebral tissue microstructure may be impacted by global brain perfusion, adding further evidence to the intimate relationship between cerebral blood supply and cerebral tissue integrity.Evidence Level4Technical EfficacyStage 4

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“…An experiment with no labeling was additionally conducted with 5 repetitions. The nonlocal estimation of multispectral magnitudes (NESMA) filter [ 38 ] was applied to the averaged images and a region of interest (ROI) spanning both the right and left hippocampus was manually defined with reference to a corresponding proton density-weighted image (Fig. 2 b).…”

Section: Methodsmentioning

confidence: 99%

Association of central arterial stiffness with hippocampal blood flow and N-acetyl aspartate concentration in hypertensive adult Dahl salt sensitive rats

Ajamu¹,

Fenner²,

Grigorova³

et al. 2021

Journal of Hypertension

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Background: Central arterial stiffness (CAS) is associated with elevated arterial blood pressure (BP) and is likely associated with stiffening of cerebral artery walls, with attendant cerebral hypoperfusion, neuronal density loss and cognitive decline. Dahl salt-sensitive (Dahl-S) rats exhibit age-associated hypertension and memory loss, even on a normal salt intake. Method: We sought to explore whether central arterial pulse wave velocity (PWV), a marker of CAS, is associated with hippocampal cerebral blood flow (CBF) and neuronal density in hypertensive Dahl-S rats. We measured systolic BP (by tail-cuff plethysmography), aortic PWV (by echocardiography) and CBF and N -acetyl aspartate (NAA) (by magnetic resonance imaging) in 6 month-old male Dahl-S rats ( n = 12). Results: Greater PWV was significantly associated with lower CBF and lower NAA concentration in the hippocampus, supporting a role of CAS in cerebrovascular dysfunction and decline in cognitive performance with aging. Conclusion: These findings implicate increased CAS in cerebral hypoperfusion and loss of neuronal density and function in the Dahl-S model of age-associated cardiovascular dysfunction.

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Spatially adaptive unsupervised multispectral nonlocal filtering for improved cerebral blood flow mapping using arterial spin labeling magnetic resonance imaging

Abstract: In-vivo estimation of CBF in the human brain from ASL imaging data was markedly improved through use of the NESMA-ASL filter. The use of NESMA-ASL may contribute significantly to the goal of high-quality high-resolution CBF mapping within a clinically feasible acquisition time.

Cited by 12 publications

References 56 publications

Association of cerebral blood flow with myelin content in cognitively unimpaired adults

Association of cerebral blood flow with myelin content in cognitively unimpaired adults

Evidence of An Association Between Cerebral Blood Flow and Microstructural Integrity in Normative Aging Using a Holistic MRI Approach

Association of central arterial stiffness with hippocampal blood flow and N-acetyl aspartate concentration in hypertensive adult Dahl salt sensitive rats

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