The effects of cerebral white matter changes on cardiovascular responses to cognitive and physical activity in a stroke population

Lewis, Gregory F.; Nyenhuis, David L.; Stebbins, Glenn T.; Murphy, Chris M.; Handelman, Mika; Harden, Emily; Heilman, Kenneth M.; Gorelick, Philip B.; Porges, Stephen W.

doi:10.1111/j.1469-8986.2012.01467.x

Cited by 6 publications

(5 citation statements)

References 76 publications

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“…The white matter connectivity of the autonomic system in normal health has received little attention, most published studies focusing on the impact of major pathology such as Parkinson's disease ( Ashraf-Ganjouei, Majd, Javinani, & Aarabi, 2018 ) or stroke ( Williamson et al., 2012 ). In consequence, the relationship between autonomic tone and the characteristics of white matter tracts have until now been unknown.…”

Section: Discussionmentioning

confidence: 99%

The autonomic brain: Multi-dimensional generative hierarchical modelling of the autonomic connectome

Ruffle

Hyare

Howard

et al. 2021

Cortex

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The autonomic nervous system governs the body's multifaceted internal adaptation to diverse changes in the external environment, a role more complex than is accessible to the methods—and data scales—hitherto used to illuminate its operation. Here we apply generative graphical modelling to large-scale multimodal neuroimaging data encompassing normal and abnormal states to derive a comprehensive hierarchical representation of the autonomic brain. We demonstrate that whereas conventional structural and functional maps identify regions jointly modulated by parasympathetic and sympathetic systems, only graphical analysis discriminates between them, revealing the cardinal roles of the autonomic system to be mediated by high-level distributed interactions. We provide a novel representation of the autonomic system—a multidimensional, generative network—that renders its richness tractable within future models of its function in health and disease.

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Section: Discussionmentioning

confidence: 99%

The autonomic brain: Multi-dimensional generative hierarchical modelling of the autonomic connectome

Ruffle

Hyare

Howard

et al. 2021

Cortex

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“…In vitro, vitamin D down-regulates the activity of NF-κB activity [204] and stimulates the anti-inflammatory cytokines [205]. Additionally, vitamin D-binding proteins are more evident in proximity to endothelium injury [206], inhibiting the expression of Matrix Metalloproteinase (MMP-2, MMP-9), and of the endothelium growth factor [207]; they probably diminish the activity of the platelet-derived growth factor, conversely up-regulating thrombomodulin [208,209]. The second study, entirely dedicated to small vessel disease and vitamin D [198], lights some shadows in a fascinating problem; it presents a public association between bone small vessel disease and osteoporosis.…”

Section: Vitamin D Deficiency and Neurodegenerative Diseasesmentioning

confidence: 99%

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

Moretti

Morelli

Caruso

2018

IJMS

130

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It is widely known that vitamin D receptors have been found in neurons and glial cells, and their highest expression is in the hippocampus, hypothalamus, thalamus and subcortical grey nuclei, and substantia nigra. Vitamin D helps the regulation of neurotrophin, neural differentiation, and maturation, through the control operation of growing factors synthesis (i.e., neural growth factor [NGF] and glial cell line-derived growth factor (GDNF), the trafficking of the septohippocampal pathway, and the control of the synthesis process of different neuromodulators (such as acetylcholine [Ach], dopamine [DA], and gamma-aminobutyric [GABA]). Based on these assumptions, we have written this review to summarize the potential role of vitamin D in neurological pathologies. This work could be titanic and the results might have been very fuzzy and even incoherent had we not conjectured to taper our first intentions and devoted our interests towards three mainstreams, demyelinating pathologies, vascular syndromes, and neurodegeneration. As a result of the lack of useful therapeutic options, apart from the disease-modifying strategies, the role of different risk factors should be investigated in neurology, as their correction may lead to the improvement of the cerebral conditions. We have explored the relationships between the gene-environmental influence and long-term vitamin D deficiency, as a risk factor for the development of different types of neurological disorders, along with the role and the rationale of therapeutic trials with vitamin D implementation.

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“…The second study, entirely dedicated to small vessel disease and vitamin D [224] lights some shadows in a fascinating problem: it presents a well-known association between bone small vessel disease and osteoporosis. Authors hypothesize a common way of alteration, in the peripheral autonomous nervous system, which deteriorates small-bone vessels as well as brain vessels [248]. The first and the third study on the topic [225][226], starting from two different perspectives have some common points.…”

Section: Vitamin D Deficiency and Neurodegenerative Diseasesmentioning

confidence: 99%

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

Moretti

Morelli

Caruso

2018

Preprint

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It is widely known that vitamin D receptors have been found in neurons and glial cells and their highest expression is in the hippocampus, hypothalamus, thalamus and subcortical grey nuclei, and substantia nigra. The vitamin D helps the regulation of neurotrophin, neural differentiation and maturation, through the control operation of growing factors synthesis (ie NGF and GDNF), the trafficking of the septo-hyppocampal pathway, and the control of the synthesis process of different neuromodulators (such as Ach, DA, and GABA).Based on these assumptions, we have written this review in order to summarize the potential role of vitamin D in neurological pathologies. The work could be titanic, and might result very fuzzy and even incoherent, if we would not have conjectured to taper our first intentions and devoted our interests towards three mainstreams: demyelinating pathologies, vascular syndromes and neurodegeneration.Due to the lack of effective therapeutic options, a part from the disease modifying strategies, the role of different risk factors should be investigated in neurology, as far as their correction may lead to the improvement of the cerebral conditions.We have explored the relationships between the gene-environmental influence and long term vitamin D deficiency, as a risk factor for the development of different types of neurological disorders, along with the role and the rationale of therapeutic trials with vitamin D implementation. Peer-reviewed version available at Int. J. Mol. Sci. 2018, 19, 2245 doi:10.3390/ijms19082245 3 SEARCH STRATEGY AND SELECTION CRITERIAWe searched MEDLINE using the search terms: "vitamin D central nervous system" , both "vitamin D" and "central nervous system"; "vitamin D immune system/response", both "vitamin D" and "immune system" or "immune response"; "vitamin D multiple sclerosis risk", both "vitamin D" and "multiple sclerosis risk"; "vitamin D multiple sclerosis relapse", both "vitamin D" and "multiple sclerosis relapse"; "vitamin D multiple sclerosis magnetic resonance imaging", both "vitamin D" and "multiple sclerosis magnetic resonance imaging"; "vitamin D multiple sclerosis disability", both "vitamin D" and "multiple sclerosis disability"; "vitamin D supplementation/therapy/treatment multiple sclerosis", both "vitamin D supplementation" or "vitamin D therapy" or "vitamin D treatment" and "multiple sclerosis"; "vascular dementia", both as -vascular-and -dementia-, "subcortical vascular dementia", both assubcortical-and -dementia-, "Alzheimer's disease", "pathogenesis neurodegeneration" "amyloid", "cholinergic afferents", "arteriolosclerosis", "cerebral flow regulation", "stroke". Publications were selected mostly form the past 20years, but did not exclude frequently referenced and highly regarded older publications. . Congress abstracts and isolated case reports were not considered. We searched the reference lists of articles identified by this search strategy and selected those we judged relevant. Review articles and book chapters are cited to provide with ...

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The effects of cerebral white matter changes on cardiovascular responses to cognitive and physical activity in a stroke population

Cited by 6 publications

References 76 publications

The autonomic brain: Multi-dimensional generative hierarchical modelling of the autonomic connectome

The autonomic brain: Multi-dimensional generative hierarchical modelling of the autonomic connectome

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

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