CeO2 Containing Thin Films as Bioactive Coatings for Orthopaedic Implants

Abstract

<jats:p>Due to the fact of their ability to bond with human’s hard tissue, bioglasses have gained interest in the biomedical field with certain purposes regarding their usage in the replacement, healing or repair of bones. In the form of thin films, they trigger an increase in biocompatibility for the inert supports after implantation, based on surface engineering to ensure osteoinduction. For that, this research is focused on obtaining coatings based on cerium-enriched bioglass to generate bioactive and potential additional antimicrobial and antioxidant properties. The addressed oxide system was a novel and complex one, 46.10 SiO2–2.60 P2O5–16.90 CaO–10.00 MgO–19.40 Na2O–5.00 CeO2 (mol%), while two different synthesis methods, laser ablation and spin coating, were tackled comparatively. In the case of the first technique, substrate temperature was selected as variable parameter (room temperature or 300 °C). After conducting a complex characterization, films’ deposition was validated, their bioactive behaviour was proven by the formation of calcium phosphate after immersion in simulated body fluid for four weeks, while the impact exerted on the tested human fibroblast BJ cells (ATCC, CRL-2522) confirmed the applicative potential.</jats:p>

CeO2 Nanoparticle-Containing Polymers for Biomedical Applications: A Review

“…The incorporation of CeO 2 in hydroxyapatite coatings for orthopedic implants can be a good strategy not only to promote osseointegration, but also to reduce implant-induced inflammatory reactions [ 46 ]. Prefac et al showed the perspective of using CeNPs-containing thin films as bioactive coatings for orthopedic implants [ 47 ]. According to recent analysis [ 19 ], the ability of cerium compounds (including CeNPs) to decrease the activity of the reticuloendothelial system can be highly promising in prosthesis or tissue engineered constructs implantation, significantly reducing graft rejection rates.…”

Ce/Sm/Sr-Incorporating Ceramic Scaffolds Obtained via Sol-Gel Route

“…CeO 2 nanoparticles employed as decoration for cancellous bone grafts significantly promoted the blood vessel development process [ 22 ]. Bioactive glassy coatings containing CeO 2 nanocrystals (5 mol% CeO 2 ) were proposed as suitable supports for fibroblast cells development, hindering in the same time bacteria colonization [ 23 ]. 3 D-printed composite scaffolds based on CaSiO 3 and maximum 15 mol% CeO 2 showed enhanced osteogenic activity [ 24 ], while polymeric scaffolds loaded with CeO 2 nanoparticles organized into self-assembled line patterns enabled aligned cell growth [ 25 ].…”

The Beneficial Mechanical and Biological Outcomes of Thin Copper-Gallium Doped Silica-Rich Bio-Active Glass Implant-Type Coatings

“…The last decades witnessed an unprecedented demand for innovative bio-functional materials, capable of not only preventing failure, but also prolonging the life time of orthopaedic/dental implants and bone grafting scaffolds. Silica-based bioactive glasses (SBG) represent a group of reactive biomaterials that possess outstanding features (e.g., bioactivity, osteoproduction, angiogenesis), which are crucial for assuring an excellent interfacial bonding between the host bone tissue and implants [1][2][3][4][5][6][7]. The continuous effervescence in the SBG realm, associated with its unique physicalchemical and biological functional properties [2,5,7], is certified by a progressive yearly increase in the number of publications [5].…”