Central serous chorioretinopathy and endogenous cortisol - is there an association?

Chalisgaonkar, Charudatt; Chouhan, Siddharth; Lakhtakia, Sujata; Choudhary, Pooja; Dwivedi, PC; Rathore, MK

doi:10.4103/0301-4738.67055

Cited by 10 publications

(3 citation statements)

References 3 publications

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“…Zakir et al [ 5 ] reported that CSC is associated with elevated 8:00 a.m. serum cortisol levels. However, Chalisgaonkar et al [ 7 ] did not find a precise correlation of the serum cortisol with CSC. Similarly, Tufan et al [ 8 ] could not identify any correlation of the serum cortisol with chronic CSC.…”

Section: Discussionmentioning

confidence: 98%

“…In contrast, Thoelen et al [ 6 ] speculated that in the pathogenesis of CSC, the deregulations of sympathetic activity play a major role and elevated glucocorticosteroid levels are involved only indirectly. Chalisgaonkar et al [ 7 ] found no precise correlation between serum cortisol levels and acute cases of CSC. Similarly, Tufan et al [ 8 ] reported normal levels of serum cortisol and testosterone in chronic CSC.…”

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confidence: 99%

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Comparison of Serum Cortisol and Testosterone Levels in Acute and Chronic Central Serous Chorioretinopathy

Natung

Keditsu

2015

Korean J Ophthalmol

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PurposeTo compare the levels of serum cortisol and testosterone in acute and chronic central serous chorio-retinopathy (CSC).MethodsSerum cortisol and testosterone levels in 30 patients with either acute or chronic CSC were evaluated using chemiluminescent immunoassay.ResultsThe mean age was 42.43 ± 6.37 years (range, 32 to 56 years). The mean 8:00 to 9.00 a.m. serum cortisol level was 12.61 ± 4.74 µg/dL (range, 6.58 to 27.42 µg/dL). The mean serum testosterone level was 5.88 ± 1.57 ng/dL (range, 2.81 to 9.94 ng/dL). The mean visual acuity was 20 / 65.07 ± 40.56 (range, 20 / 25 to 20 / 200). There was no statistically significant difference in the mean levels of serum cortisol and testosterone between the acute and chronic cases (p > 0.05), but there was a statistically significant difference in the mean presenting visual acuity in the two groups (p < 0.05).ConclusionsAll except one patient in the acute group had normal levels of serum cortisol. Testosterone levels were within the normal range in both the acute and chronic cases of CSC. There is unlikely to be any statistically significant difference in the mean levels of serum cortisol and testosterone between the acute and chronic cases, but there may be a statistically significant difference in the mean presenting visual acuity in these groups.

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Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 99%

Comparison of Serum Cortisol and Testosterone Levels in Acute and Chronic Central Serous Chorioretinopathy

Natung

Keditsu

2015

Korean J Ophthalmol

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“…Previously, concentrations of steroid hormones, such as cortisol, aldosterone, and testosterone, have been widely investigated in patients with CSC; however, the findings have not been consistent, showing associations in some studies but not in others [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. Serotonin (5-hydroxytryptamine (5-HT)), a neurotransmitter, influences many brain functions and plays important roles in the gastrointestinal system, blood, and brain, affecting behavior and physiology [ 17 ].…”

Section: Introductionmentioning

confidence: 98%

Central Serous Chorioretinopathy and Blood Serotonin Concentrations

Kondo

Araki

Komuku

et al. 2021

JCM

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Background: To investigate blood serotonin (5-hydroxytryptamine (5-HT)) concentrations and their relationships with selected characteristics in patients with central serous chorioretinopathy (CSC). Methods: This was a prospective study including 93 patients with active CSC. Blood concentrations of 5-HT, adrenocorticotropic hormone, and cortisol were measured in patients with CSC. Selected patient characteristics, including disease history (acute or chronic), medication use, smoking history, mood status, best-corrected visual acuity (BCVA), subfoveal choroidal thickness (SCT), findings on fluorescein and indocyanine green angiography, and anatomical changes were evaluated during follow-up. Results: Eleven of the 93 patients had low 5-HT concentrations (<57 ng/mL) (12%, eight men and three women; mean age 55 years); we identified no significant relationship with acute/chronic disease status. The patients with low 5-HT were significantly more likely to have five or more fluorescein leakage sites (p = 0.0275), recurrence of subretinal fluids (p < 0.0001), and failure to achieve significant improvement in BCVA during follow-up (p = 0.862) than patients with 5-HT within the normal range. Conclusions: Blood serotonin concentrations may influence the pathophysiology and prognosis of CSC.

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The relationship between the central serous chorioretinopathy, choroidal thickness, and serum hormone levels

Çiloğlu

Ünal

Doğan

2018

Graefes Arch Clin Exp Ophthalmol

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Central serous chorioretinopathy and endogenous cortisol - is there an association?

Cited by 10 publications

References 3 publications

Comparison of Serum Cortisol and Testosterone Levels in Acute and Chronic Central Serous Chorioretinopathy

Comparison of Serum Cortisol and Testosterone Levels in Acute and Chronic Central Serous Chorioretinopathy

Central Serous Chorioretinopathy and Blood Serotonin Concentrations

The relationship between the central serous chorioretinopathy, choroidal thickness, and serum hormone levels

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