Central retinal vessel trunk exit and location of glaucomatous parapapillary atrophy in glaucoma11The authors have no propriety interests in the products or devices mentioned herein.

Jonas, Jost B.; Budde, Wido M.; Németh, János; Gründler, Anselm; Mistlberger, Andrea; Hayler, Jochen

doi:10.1016/s0161-6420(01)00571-1

Cited by 54 publications

(17 citation statements)

References 18 publications

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“…As expected from previous clinical studies, the vast majority of blood vessels entered the LC near the center of the optic nerve, with a slightly nasal tendency (Fig. 4 ) 7 Previous ex vivo 15 , 16 and in vivo 17 studies have shown larger pores in the superior and inferior regions of the LC structure. The slightly nasal preference may be the result of the nasal side serving a relatively sparse population of axon bundles compared to the superior and inferior quadrants 18 .…”

Section: Discussionsupporting

confidence: 84%

“…The location of the central retinal vessel trunk (CRVT) is a topic of clinical significance, as its location has been associated with susceptibility to glaucomatous damage and peripapillary atrophy 5 , 7 . Regions of the neuroretinal rim that are close to the CRVT appear to be less affected by glaucomatous damage until late into the disease.…”

Section: Introductionmentioning

confidence: 99%

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Location of the Central Retinal Vessel Trunk in the Laminar and Prelaminar Tissue of Healthy and Glaucomatous Eyes

Wang

Lucy

Schuman

et al. 2017

Sci Rep

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Glaucoma is a leading cause of blindness that leads to characteristic changes in the optic nerve head (ONH) region, such as nasalization of vessels. It is unknown whether the spatial location of this vessel shift inside the ONH occurs within the lamina cribrosa (LC) or the prelaminar tissue. The purpose of this study was to compare the location of the central retinal vessel trunk (CRVT) in the LC and prelaminar tissue in living healthy and glaucomatous eyes. We acquired 3-dimensional ONH scans from 119 eyes (40 healthy, 29 glaucoma suspect, and 50 glaucoma) using optical coherence tomography (OCT). The CRVT location was manually delineated in separate projection images of the LC and prelamina. We found that the CRVT in glaucoma suspect and glaucomatous eyes was located significantly more nasally compared to healthy eyes at the level of the prelamina. There was no detectable difference found in the location of the CRVT at the level of the LC between diagnostic groups. While the nasal location of the CRVT in the prelamina has been associated with glaucomatous axonal death, our results suggest that the CRVT in the LC is anchored in the tissue with minimal variation in glaucomatous eyes.

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Location of the Central Retinal Vessel Trunk in the Laminar and Prelaminar Tissue of Healthy and Glaucomatous Eyes

Wang

Lucy

Schuman

et al. 2017

Sci Rep

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“…This supports a previous smaller study [13]. It shows a difference between eyes with glaucomatous optic neuropathy and NA-AION with optic nerve damage: while in glaucoma, parapapillary atrophy enlarges and shows a spatial relationship with the loss of neuroretinal rim inside of the optic disc and with the longest distance to the central retinal vessel trunk [24], parapapillary atrophy in NA-AION does not change markedly. This gives another criterion to differentiate between glaucoma and NA-AION.…”

Section: Discussionsupporting

confidence: 90%

Optic Nerve Head Change in Non-Arteritic Anterior Ischemic Optic Neuropathy and Its Influence on Visual Outcome

et al. 2012

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PurposeTo evaluate changes in cup/disc (C/D) diameter ratios and parapapillary atrophy in patients with non-arteritic anterior ischemic optic neuropathy (NA-AION), using morphometric methods.MethodsThe clinical non-interventional study included 157 patients with unilateral or bilateral NA-AION. Optic disc photographs taken from both eyes at the end of follow-up were morphometrically examined.ResultsFollow-up was 86.3±70.3 months. Horizontal and vertical disc diameters (P = 0.30;P = 0.61, respectively), horizontal and vertical C/D ratios (P = 0.47;P = 0.19,resp.), and size of alpha zone and beta zone of parapapillary atrophy (P = 0.27;P = 0.32,resp.) did not differ significantly between affected eyes and contralateral normal eyes in patients with unilateral NA-AION. Similarly, horizontal and vertical disc diameters, horizontal and vertical C/D ratios, and size of alpha zone and beta zone did not vary significantly (all P>0.05) between the unaffected eyes of patients with unilateral NA-AION and the eyes of patients with bilateral NA-AION. Optic disc diameters, C/D ratios, size of alpha zone or beta zone of parapapillary atrophy were not significantly associated with final visual outcome in the eyes affected with NA-AION (all P>0.20) nor with the difference in final visual acuity between affected eyes and unaffected eyes in patients with unilateral NA-AION (all P>0.25).ConclusionsNA-AION did not affect C/D ratios nor alpha zone and beta zone of parapapillary atrophy. Optic disc size was not related to the final visual acuity outcome in NA-AION.

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“…10 In our study, we have shown that the correlation between CRVTL and central VF loss is not restricted to severe glaucoma, and CRVTL is also significantly correlated to central VF loss in mild and moderate glaucoma. A previous study 23 also has shown that nasalized CRVTL was related to thinner temporal RNFLT. However, since nasalized CRVTL is also associated with more temporal retinal vessel trajectories outside the ONH that correspond to the RNFLT peak, it cannot be distinguished whether the observed thinning of temporal RNFLT was attributable to pathologic cause or anatomic variation.…”

Section: Discussionmentioning

confidence: 69%

Relationship Between Central Retinal Vessel Trunk Location and Visual Field Loss in Glaucoma

Wang

Pasquale

et al. 2017

American Journal of Ophthalmology

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PURPOSE To study the relationship between horizontal central retinal vessel trunk location (CRVTL) on glaucomatous optic discs and sector-specific visual field (VF) loss. DESIGN Retrospective cross-sectional study. METHODS CRVTL of 421 eyes from 421 patients was manually tracked on the horizontal optic disc axis on fundus images. Focal circumpapillary retinal nerve fiber layer thickness (cpRNFLT) measurements were extracted from optical coherence tomography (OCT). The relationship between focal visual field (VF) loss and CRVTL and focal cpRNFLT was studied by linear regression models. Furthermore, we related central VF loss to CRVTL and focal cpRNFLT separately for mild (VF mean deviation [MD] ≥−6 dB), moderate (−12 dB ≤ MD <−6 dB), and severe (MD <−12 dB) glaucoma. RESULTS CRVTL nasalization was significantly correlated only to central VF loss (Garway-Heath scheme [central 6 locations, C6]: correlation: r = −0.16, P < .001; macular vulnerability zone [central 2 locations, C2]: r = −0.14, P = .003; central 4 locations [C4]: r = −0.17, P < .001). While focal cpRNFLT at the sectors corresponding to C2 and C6 was significantly correlated to the respective VF sectors as well (C2: r = 0.15, P = .002; C6: r = 0.10, P = .03), multivariate models combining cpRNFLT and CRVTL substantially improved structure-function models compared with cpRNFLT alone (likelihood ratio tests, C2 and C6: P < .001). The correlations between CRVTL and central VF loss of C4 were −0.11 (P = .04), −0.39 (P = .01), and −0.63 (P = .002) for mild, moderate, and severe glaucoma, respectively. CONCLUSIONS CRVTL nasalization is significantly and exclusively correlated to central VF loss for all glaucoma severities independent of cpRNFLT, and thus might be a structural biomarker of central VF loss.

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Central retinal vessel trunk exit and location of glaucomatous parapapillary atrophy in glaucoma11The authors have no propriety interests in the products or devices mentioned herein.

Cited by 54 publications

References 18 publications

Location of the Central Retinal Vessel Trunk in the Laminar and Prelaminar Tissue of Healthy and Glaucomatous Eyes

Location of the Central Retinal Vessel Trunk in the Laminar and Prelaminar Tissue of Healthy and Glaucomatous Eyes

Optic Nerve Head Change in Non-Arteritic Anterior Ischemic Optic Neuropathy and Its Influence on Visual Outcome

Relationship Between Central Retinal Vessel Trunk Location and Visual Field Loss in Glaucoma

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