Central Nervous System Manifestations of Infectious Mononucleosis

Acute Cerebellar Ataxia and Hearing Loss as Initial Symptoms of Infectious Mononucleosis

“…An alternate binaural loudness bal¬ ancing test showed right cochlear involve¬ ment. Brain-stem auditory evoked re¬ sponse was normal on the left and abnor¬ mal on the right (left I to III latency, 2.28 ms; I to V latency, 3.76 ms; and III to V latency, 1.48 ms; no reproducible wave forms could be obtained from right-ear stimulation, which was consistent with cochlear involvement). A computed tomo¬ graphic scan of the brain was normal.…”

Epstein-Barr virus-associated cerebellar ataxia

“…Meningitis, encephalitis, mononeuritis, Guillain-Barre syndrome, ophthalmoplegia, optic neuritis and acute demyelinating encephalomyelitis (ADEM) have been described. Acute cerebellar ataxia is a rare neurological complication of EBV infection;1–3 it was first described by Landes and colleagues in 1941 4…”

Fatal Encephalopathy in Glandular Fever

“…An account of these varied neurological manifestations of the condition has been provided by Kissel, Arnould, and Leval (1952). Landes, Reich, and Perlow (1941) referred to a dozen cases in the literature; Bernstein and Wolff (1950) reviewed 34 published cases; Silversides and Richardson (1950) collected 59; Freedman, Odland, and Cleve (1953) found 54 cases and Leibowitz (1953) reviewed 71 in his monograph on glandular fever; Walsh, Poser, and Carter (1954) spoke of approximately 100 cases in the literature.…”

“…Librach (1952) published a case of encephalitis and later (1954) another. Other individual reports of encephalitis have come from Landes et al (1941), Zohman andSilverman (1942), Geliebter (1946), Slade (1946), Schneider and Michelson (1947), Dolgopol and Husson (1949), McNeel (1951), and Hubler, Bailey, Campbell, and Mathieson (1951. Nineteen of the 59 cases collected by Silversides and Richardson (1950), four of the 34 reported by Bernstein and Wolff (1950), and 15 of the 71 reviewed by Leibowitz (1953) were encephalitic.…”

“…This was so in the case reported by Hoyne (1950) where glandular fever was unmistakable, and vertigo and ataxia persisted for a long time. These authors refer to a case previously published by Landes et al (1941) in which giddiness, unsteadiness, and acute ataxia were present although no attempt was made to localize the responsible lesion. In the case of Freedman et al (1953) there was difficulty in coordinating movements of the limbs during the convalescent phase.…”