Fatal Encephalopathy in Glandular Fever

Bergin, James D.

doi:10.1136/jnnp.23.1.69

Cited by 50 publications

(6 citation statements)

References 33 publications

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“…9 (Fig. 3a) [Bergin, 1960;Roulet-Perez et al, 1993]. The second, characterised by perivascular mononuclear infiltrates and occasional viral inclusions in cortical and subcortical cells, resembles the encephalitis of patient no.…”

Section: Discussionmentioning

confidence: 89%

Neurological complications of acute and persistent Epstein‐Barr virus infection in paediatric patients

Häusler

Ramaekers

Doenges

et al. 2002

Journal of Medical Virology

109

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Neurological complications of Epstein-Barr virus (EBV) have been reported almost exclusively in the course of acute primary infections. The role of EBV in paediatric neurological disease was investigated prospectively over a 2-year period, searching for acute primary, chronic, and reactivated EBV infections. Active EBV infections were diagnosed in 10/48 patients, including two with acute primary EBV infections (cranial neuritis and cerebellitis), one with chronic active infection (T/NK cell lymphoma with cranial neuritis), and seven with reactivated infections. Among these seven patients, three showed "Alice in Wonderland" syndrome, one facial nerve palsy, one progressive macrocephaly, and two prolonged encephalitic illness. The prognosis was good except for the patient with lethal T/NK cell lymphoma and the two girls with encephalitic illness. Despite steroid treatment, these girls suffered prolonged cognitive impairment and epileptic seizures. Both developed left-sided hippocampal atrophy, and one of them hippocampal sclerosis. Like primary infections, reactivated EBV infections cause neurological complications in a considerable number of paediatric patients, lead to serious long-term complications, and may contribute to the pathogenesis of hippocampal lesions.

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Section: Discussionmentioning

confidence: 89%

Neurological complications of acute and persistent Epstein‐Barr virus infection in paediatric patients

Häusler

Ramaekers

Doenges

et al. 2002

Journal of Medical Virology

109

View full text Add to dashboard Cite

show abstract

“…However, Bergin (1960), suggested that an 'allergic neurotaxitis' similar to that found in the encephalitis of measles and some other specific fevers might be responsible for some of the neurological manifestations of infectious mononucleosis. Summary A patient with subacute bacterial endocarditis is presented in whom an intra-abdominal mycotic aneurysm was diagnosed prior to the development of cardiac signs.…”

Section: Discussionmentioning

confidence: 99%

Hypoglossal nerve palsy complicating a case of infectious mononucleosis

Sibert¹

1972

Postgraduate Medical Journal

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SummaryA case of infectious mononucleosis complicated by the rare neurological complication of left isolated hypoglossal nerve palsy is described. The literature on cranial nerve palsies in infectious mononucleosis is briefly reviewed.Case report R.G., a 17-year-old management trainee, was admitted to the Radcliffe Infirmary with a 1 week history of sore throat, headache loss of appetite, shivers, nausea and malaise. He had been given a course of penicillin V on the second day of his illness by his general practitioner without improvement.

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“…Degenerative changes have been observed in neurons located in the cerebral cortex, the midbrain and basal ganglia, the cerebellum, and the medulla, as well as in Clarke's and the anterior columns of the spinal cord (Bergin 1960). Infiltrates of mononuclear cells also have been found around the peripheral nerves.…”

Section: Charles Grosementioning

confidence: 99%

Infectious Mononucleosis

1989

Clinical Topics in Infectious Disease

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Infectious mononucleosis is a clinical entity characterized by pharyngitis, cervical lymph node enlargement, fatigue and fever, which results most often from a primary Epstein-Barr virus (EBV) infection. EBV, a lymphocrytovirus and a member of the γ-herpesvirus family, infects at least 90% of the population worldwide, the majority of whom have no recognizable illness. The virus is spread by intimate oral contact among adolescents, but how preadolescents acquire the virus is not known. During the incubation period of approximately 6 weeks, viral replication first occurs in the oropharynx followed by viremia as early as 2 weeks before onset of illness. The acute illness is marked by high viral loads in both the oral cavity and blood accompanied by the production of immunoglobulin M antibodies against EBV viral capsid antigen and an extraordinary expansion of CD8 + T lymphocytes directed against EBV-infected B cells. During convalescence, CD8 + T cells return to normal levels and antibodies develop against EBV nuclear antigen-1. A typical clinical picture in an adolescent or young adult with a positive heterophile test is usually sufficient to make the diagnosis of infectious mononucleosis, but heterophile antibodies are not specific and do not develop in some patients especially young children. EBV-specific antibody profiles are the best choice for staging EBV infection. In addition to causing acute illness, long-term consequences are linked to infectious mononucleosis, especially Hodgkin lymphoma and multiple sclerosis. There is no licensed vaccine for prevention and no specific approved treatment. Future research goals are development of an EBV vaccine, understanding the risk factors for severity of the acute illness and likelihood of developing cancer or autoimmune diseases, and discovering anti-EBV drugs to treat infectious mononucleosis and other EBV-spurred diseases.

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Fatal Encephalopathy in Glandular Fever

Cited by 50 publications

References 33 publications

Neurological complications of acute and persistent Epstein‐Barr virus infection in paediatric patients

Neurological complications of acute and persistent Epstein‐Barr virus infection in paediatric patients

Hypoglossal nerve palsy complicating a case of infectious mononucleosis

Infectious Mononucleosis

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