Central nervous system depressant activity of Russelia equisetiformis

Kolawole, O. T.; Makinde, J. M.; Olajide, Olumayokun A.

doi:10.4314/njps.v22i1-2.54865

Cited by 22 publications

(22 citation statements)

References 14 publications

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“…Carrageenan‐induced paw puffiness has been most notably used in experimental animal models for the assessment of acute inflammation and is considered to be biphasic, with the early phase (1‐2 hours) of the carrageenan model being principally mediated by histamine, serotonin, and enhanced synthesis of autacoids in injured tissue, while the late phase is mediated by bradykinin, leukotrienes, polymorphonuclear cells, and prostaglandins made by tissue macrophages . In our study, the crude methanolic acetate fraction of P .…”

Section: Discussionmentioning

confidence: 86%

“…stratoites produced significant inhibition of paw puffiness from 0 minutes to 3 hours, which was comparable with the effect of standard ibuprofen. A possible mechanism for the extract's observed anti‐inflammatory activity might be its ability to reduce the release of histamine, serotonin or kinin‐like substances or biosynthesis of prostaglandins …”

Section: Discussionmentioning

confidence: 99%

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An in vivo study of the pharmacological activities of a methanolic acetate fraction of Pistia stratiotes L.: An ethno‐medicinal plant used in Bangladesh

Hussain

Ibrahim

Hasan

et al. 2018

Anim Models and Exp Med

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Background The present study covered an assessment of methanolic acetate fractions of Pistia stratiotes , commonly known as water lettuce, for analgesic, anti‐inflammatory, and CNS depressant activities. Methods The methanol acetate fractions were extracted from Pistia stratiotes and administered to the experimental animals as 200 and 400 mg/kg doses to determine the effect on acetic acid‐induced writhing and formalin‐induced licking and biting, for the assessment of analgesic activity. The anti‐inflammatory assay was done using the carrageenan‐induced hind paw edema method, while assessment of CNS depressant activity was done using the open field and hole cross tests. The effects were compared to standard reference drugs. Results At both doses (200 and 400 mg/kg body weight), the methanolic acetate extract of P. stratiotes showed significant analgesic action ( P < 0.05) against acetic acid‐induced writhing. The extract was also found to give significant protection against licking and biting at both doses. The methanolic acetate extract of P. stratiotes showed a significant ( P < 0.05) anti‐inflammatory effect from 0 minutes up to 3 hours in the carrageenan‐induced paw edema test. In the CNS depressant assay, the methanolic acetate extract showed significant ( P < 0.05) depressant activity at both doses from 30 to 120 minutes in both the hole cross and open field tests. Conclusion Thus we can conclude that P. stratiotes extracts have significant analgesic, anti‐inflammatory, and CNS depressant activity, compared to standard compounds, in an animal model.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

An in vivo study of the pharmacological activities of a methanolic acetate fraction of Pistia stratiotes L.: An ethno‐medicinal plant used in Bangladesh

Hussain

Ibrahim

Hasan

et al. 2018

Anim Models and Exp Med

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“…Gamma-aminobutyric acid (GABA) is evidenced to be the major inhibitory neurotransmitter of CNS and several anxiolytic, muscle relaxant and sedative-hypnotic drugs exhibit their action via GABA [36]. Thus it can be pretended that the methanolic seed extract may act by commencing the GABAergic inhibition of the CNS through membrane hyperpolarization that lead to a reduction in the firing rate of critical neurons in the brain or the extract may simply activate the GABA receptors directly [37]. Again, research has shown that plants containing alkaloids, flavonoids and tannins are useful for the treatment of many CNS disorders as they reduce the locomotor activity of the CNS [38] which led to the postulation that these compounds may act as benzodiazepine like molecules [39].…”

Section: Discussionmentioning

confidence: 99%

Phytochemical and pharmacological evaluation of methanolic extract of Lathyrus sativus L. seeds

Bhattacharjee¹,

Waqar²,

Barua³

et al. 2018

Clin Phytosci

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Background: Lathyrus sativus L. (Fabaceae) has long been used as a traditional medicine for the treatment of several ailments such as Scabies, eczema, and allergy. The aim of the study was to evaluate the phytochemical nature with Central Nervous System (CNS) depressant, analgesic, antipyretic activities of the methanolic plant extract of Lathyrus sativus L. seeds in different experimental models. Methods: Preliminary phytochemical screening and proximate analysis was carried out using different standard methods. CNS depressant activity was evaluated observing the effects of plant extract on Swiss albino mice using open field and hole-cross method. Acetic acid induced writhing and formalin induced paw licking methods were used for the appraisal of analgesic activity while 2,4-dinitrophenol (DNP) induced pyrexia model was used to investigate the antipyretic activity. The data were analyzed by one way ANOVA followed by Dunnett's test using SPSS (version 20). Results: The phytochemical analysis revealed the presence of wide range of phytoconstituents in the plant extract. Our investigation demonstrated that the methanolic plant extract significantly (p < 0.001) decreased the locomotor activity of mice in open field and hole-cross method at both the tested doses (200 and 300 mg/kg) which were comparable to the standard drug diazepam (1 mg/kg). The plant extracts significantly (p < 0.001) inhibited the writhing induced by acetic acid in mice to 87.09% and 80.65% (200 and 300 mg/kg respectively) compared to the standard indomethacin (70.97%). The extracts (200 and 300 mg/kg respectively) also significantly (p < 0.001) reduced the writhing to 43.39%, 64.15% in early and 46.15%, 97.44% in late phase of formalin-induced licking and biting. In 2,4-DNP induced pyrexia the extracts exhibited protection at 200 and 400 mg/kg, similar to standard drug aspirin at 150 mg/kg. Conclusion: The results demonstrated that the plant extract has potential CNS depressant, analgesic and antipyretic activity.

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“…Different anxiolytic, muscle relaxant, sedative-hypnotic drugs are elucidation their action through GABA A , therefore it is possible that extract of P. longum may acts by potentiating GABAergic inhibition in the CNS via membrane hyperpolarization which leads to a decrease in the firing rate of critical neurons in the brain or may be due to direct activation of GABA receptor by the extract 15 . The fruits of Piper longum L. contains amide alkaloids, flavonoids, essential oils, lignans and the root contains amide alkaloids but the phytochemical compositions of the leaves is still unknown.…”

Section: Discussionmentioning

confidence: 99%

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2011

IJPSR

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Present study reports CNS depressant and analgesic activities of methanol extract obtained from the leaves of Piper longum L (MEPL). CNS depressant activity was evaluated by using open field and hole cross tests at doses of 250 and 500 mg/kg body weight while peripheral analgesic activity was evaluated by using acetic acid induced writhing method and formalin test respectively in rat model at 100 and 200 mg/kg body weight. The results of the statistical analysis showed that the plant extract had significant (p<0.01) dose dependent CNS depressant and analgesic activities. Locomotor activity and exploratory behavior of rats in hole cross and open field test were decreased in the test group comparing the control group indicating CNS depressant effect of the extract which was comparable with the standard drug diazepam. The extract also showed better analgesic effects at both doses characterized by reduction in the number of writhes in the acetic acidinduced writhing model and reduction of licking time in the formalin test when compared to the control group. The extract, at the dose of 200 mg/kg, exerted a maximum of 57.58% inhibition of writhing response and 58.8% inhibition was observed for reference drug Indomethacin. So, the present results suggest that the methanol extract of P. longum leaves possesses remarkable CNS depressant and analgesic activities.

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Central nervous system depressant activity of Russelia equisetiformis

Cited by 22 publications

References 14 publications

An in vivo study of the pharmacological activities of a methanolic acetate fraction of Pistia stratiotes L.: An ethno‐medicinal plant used in Bangladesh

An in vivo study of the pharmacological activities of a methanolic acetate fraction of Pistia stratiotes L.: An ethno‐medicinal plant used in Bangladesh

Phytochemical and pharmacological evaluation of methanolic extract of Lathyrus sativus L. seeds

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