Central Nervous System and its Disease Models on a Chip

Three-dimensional neuronal cell culture: in pursuit of novel treatments for neurodegenerative disease

“…[56] Over the years, various microfluidic devices have been developed to provide insights into the pathophysiology of neurodegenerative disorders. [57] For example, Choi et al and Cho et al utilized a microfluidic-based approach to investigate the effects of amyloid-β (aggregation) on neurons and microglia, respectively. [58,59] In their study, Choi et al used a low-flow microfluidic system to assess the neurotoxicity of time-dependent amyloid-β aggregation and the effect of physiological flow on neuronal cell survival.…”

Tissue Engineering and Regenerative Medicine 2015: A Year in Review

“…While recent endeavors such as the Human Connectome Project offer hope that we may be able to better understand its inner workings in health and disease, 60 neural tissue microplatforms can complement in vivo studies in animals and humans (mostly using imaging modalities) and serve as controllable models for drug testing and disease modeling. 61,62 Compared to other tissues, 3D culture systems for de novo brain tissue engineering are relatively new. Notably, this past year saw a number of interesting developments.…”

Three‐Dimensional Models of the Human Brain Development and Diseases

“…They allow manipulation of cellular microenvironment and endow scientists with a new tool set that raises the complexity of tissues containing multiple cell types in the laboratory to new levels of sophistication in organs-on-chip constructs. [6,7] These 3D physiologically relevant cell culture systems aim to closely mimic the human tissues and provide high-throughput and reproducible studies. The 3D cell-cell interactions and physiological cues provided by the extracellular matrix (ECM) tend to offer an in vivo-like environment to the cells.…”