Central nervous system and analgesic profiles of Lippia genus

Siqueira-Lima, Pollyana S.; Passos, Fabíolla Rocha Santos; Lucchese, Angélica Maria; Menezes, Irwin Rose Alencar de; Coutinho, Henrique Douglas Melo; Lima, Alexandre A. B.; Zengin, Gökhan; Quintans, Jullyana S.S.; Quintans‐Júnior, Lucindo J.

doi:10.1016/j.bjp.2018.11.006

Cited by 19 publications

(6 citation statements)

References 115 publications

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“…The treated animals showed an anxiolytic effect, as substances that fight anxiety increase the time spent by the animals in the clear region of the aquarium, while drugs that induce anxiety decrease it 28 . In the review study on the pharmacological effects of the Lippia genus on the central nervous system, several studies were identified demonstrating the sedative, anxiolytic, and anti-convulsant effects of plants of the genus, being responsible for these pharmacological actions nonvolatile substances such as phenylpropanoids, flavonoids and/or or inositols 69 .…”

Section: Discussionmentioning

confidence: 99%

Analysis toxicity by different methods and anxiolytic effect of the aqueous extract Lippia sidoides Cham.

Camilo

Leite

Mendes

et al. 2022

Sci Rep

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Lippia sidoides Cham. (Verbenaceae) is a species often mentioned in traditional medicine due to the medicinal properties attributed to its leaves, which include antibacterial, antifungal, acaricidal and antioxidant. Several of these actions have been scientifically proven, according to reports in the literature; however, little is known about toxicological aspects of this plant. This work included studies to determine the chemical composition and toxicity tests, using several methods aiming to evaluate the safety for use of the aqueous extract of L. sidoides leaves, in addition, the anxiolytic effect on adult zebrafish was investigated, thus contributing to the pharmacological knowledge and traditional medicine concerning the specie under study. The chemical profile was determined by liquid chromatography coupled to mass spectrometry-HPLC/MS with electrospray ionization. Toxicity was evaluated by zebrafish, Drosophila melanogaster, blood cells, and Artemia salina models. 12 compounds belonging to the flavonoid class were identified. In the toxicity assays, the observed results showed low toxicity of the aqueous extract in all tests performed. In the analysis with zebrafish, the highest doses of the extract were anxiolytic, neuromodulating the GABAa receptor. The obtained results support the safe use of the aqueous extract of L. sidoides leaves for the development of new drugs and for the use by populations in traditional medicine.

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Section: Discussionmentioning

confidence: 99%

Analysis toxicity by different methods and anxiolytic effect of the aqueous extract Lippia sidoides Cham.

Camilo

Leite

Mendes

et al. 2022

Sci Rep

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show abstract

“…They are formed in plants from the aromatic amino acids phenylalanine and malonate. 5,105 The general analgesic effect of flavonoids is through the activation of the Nrf2 / HO-1 pathway. Flavonoids can act on 5-HT2 and 5-HT3 receptors, which may be involved in the mechanism of central analgesic activity.…”

Section: Analgesic Mechanisms Of Natural Com-poundsmentioning

confidence: 99%

Potential Activity of Medicinal Plants as Pain Modulators: A Review

Silva-Correa¹,

Campos-Reyna²,

Torre³

et al. 2021

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This review aims to demonstrate the relevance that medicinal plants and their promising results have in prevention and treatment of pain. The neurophysiological bases of pain have been analyzed and the potential mechanisms of action have been proposed, it has also been determined that the main experimental models used for the evaluation of the analgesic potential are: acetic acid-induced writhing test, formalin test, hot-plate test, capsaicin-induced nociception, cinnamaldehyde-induced nociception, glutamate-induced nociception, tail-flick test and tail immersion test. There are countless medicinal plants with potential analgesic activity, in some of them main responsible compounds for the activity are flavonoids (vitexin, quercetin, naringenin, astragalin, eupatilin), alkaloids (scotanamine B, bullatine A, S-(+)dicentrine, stephalagine, lappaconitine), terpenoids (p-cymene, thymol, menthol, citronellol, myrcene, carvacrol, linalool) and saponins (siolmatroside I, cayaponoside D, cayaponoside B4, cayaponoside A1); however, all studies have only been carried out up to pre-clinical stages. Therefore, it is recommended to carry out kinetic studies of the most remarkable natural compounds, evaluate mixtures of active compounds for diminishing doses to avoide possible side effects, and continue with clinical studies of medicinal plants whose safety has already been reported.

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“…They are usually sold for the treatment of different types of pain, including stomach pain, abdominal pain, and headache, and are used as sedatives, anxiolytics, and anticonvulsants [108]. Lippia alba, L. multiflora, L. gracilis, L. grata, L. origanoides, L. graveolens, L. geminata, L. origanoides, and L. adoensis are the species that have reports worldwide on their effect on system disorders such as central nervous, pain, and inflammation [109].…”

Section: Effects Of Medicinal Plants On Animal Models Of Painmentioning

confidence: 99%

Pharmaceutical and Botanical Management of Pain Associated with Psychopathology: A Narrative Review

Lozano¹,

Sánchez²,

Rodríguez³

et al. 2020

Behavioral Pharmacology - From Basic to Clinical Research

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Generally, pain can be described as an unpleasant sensory or emotional experience associated with tissue damage. Chronic pain has become a public health problem because among 35 and 75% of the world population has shown the symptom. In particular, neuropathic pain has shown high comorbidity disorders such as anxiety and depression. Conventional therapies for treating pain include nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, tricyclic antidepressants, anticonvulsants, and opioids, which usually cause some side effects such as gastritis, headache, liver and kidney toxicity, and drug dependence. Conventional pharmaceuticals also tend to be expensive, and they cannot be easily afforded in developing countries, which have led to the use of natural products as an alternative treatment. In this chapter, we reviewed the current research of natural products for pain treatment. We also describe preclinical studies that assess the effect of some natural products on pain therapy, phytochemistry research, toxicity, adverse effects, and biosecurity. We also describe how conventional pain is managed and the possible use of compounds obtained from vegetable species for pain treatment.

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Central nervous system and analgesic profiles of Lippia genus

Cited by 19 publications

References 115 publications

Analysis toxicity by different methods and anxiolytic effect of the aqueous extract Lippia sidoides Cham.

Analysis toxicity by different methods and anxiolytic effect of the aqueous extract Lippia sidoides Cham.

Potential Activity of Medicinal Plants as Pain Modulators: A Review

Pharmaceutical and Botanical Management of Pain Associated with Psychopathology: A Narrative Review

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