Central nervous ?-adrenergic receptors and the mode of action of ?-methyldopa

Heise, A; Kroneberg, G.

doi:10.1007/bf00500607

Cited by 69 publications

(8 citation statements)

References 26 publications

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“…Injection of a-adrenoceptor agonists into ventricles of the brain may cause either pressor or depressor responses, possibly reflecting the site of interaction of the drugs with the neurones in the brain (Gagnon & Melville, 1966;Heise & Kroneberg, 1973;Correa & Graeff, 1974;Sinha & Schmitt, 1974;Day & Roach, 1974). In our experiments a-methylnoradrenaline given intraventricularly in cats anaesthetized with chloralose caused pressor responses with no associated fall in blood pressure; similar results were observed when catecholamines were injected directly into the posterior hypothalamus (Philippu,Przuntek,Heyd & Burger,197 1).…”

Section: Discussionmentioning

confidence: 99%

Studies on the Hypotensive Action of Α‐methyldopamine

Finch

Hersom

Hicks

1975

British J Pharmacology

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I Intraventricular a-methyldopamine (50-200 gg) produced a dose-related fall in blood pressure in conscious spontaneously hypertensive rats. Pretreatment with intraventricular 6-hydroxydopamine prevented this hypotensive effect of a-methyldopamine. 2 The hypotensive effect of a-methyldopamine was prevented by intraventricular injection of phentolamine or desmethylimipramine, but not by intraperitoneal injection of haloperidol.3 Pretreatment with U-14,624, a selective central dopamine-4-hydroxylase inhibitor, prevented the hypotensive effect of a-methyldopamine. 4 cx-Methyldopamine was considerably less potent than noradrenaline as a pressor agent in the pithed rat, but noradrenaline and cx-methylnoradrenaline were found to be equipotent. 5 a-Methyldopamine (1-5 mg i.c.v.) reduced pressor responses elicited by electrical stimulation of the midbrain reticular formation in cats anaesthetized with chloralose. 6 It is concluded that the hypotensive action of ca-methyldopamine in conscious animals involves intact central ca-adrenergic neurones and a central adrenergic uptake mechanism for the formation of a-methylnoradrenaline.

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Section: Discussionmentioning

confidence: 99%

Studies on the Hypotensive Action of Α‐methyldopamine

Finch

Hersom

Hicks

1975

British J Pharmacology

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“…MAiTRE [129] found no antagonism of norepinephrine-induced hypertension by IX-methylnorepinephrine in peripheral organs, nor could a correlation between catecholamine depletion in the heart and pressor response be established [130]. A third hypothesis has, therefore, advanced postulating a central IX-receptor blockade [131]. …”

Section: ~H2mentioning

confidence: 97%

Antihypertensive Agents

Wilhelm¹,

deStevens²

1976

Progress in Drug Research/Fortschritte Der Arzneimittelforschung/Progrés Des Recherches Pharmaceutiques

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“…However, taking into account the fact that the depressor effect o f a-M D is mediated by a central mechanism [2,3], via the formation o f a-m N A or am D A , it is more probable that a-m N A and a-m D A would act by a central effect.…”

Section: Discussionmentioning

confidence: 99%

“…Since it is generally accepted that a -M D acts via the so-called 'false transmitters', a-mcthyldopamine (amDA) and a-methylnoradrenaline (a-mNA) [2,3], it was thought that the investigation of the possible antiulcer effects o f a-m D A and a-m N A would be o f interest. This paper presents our results obtained in this topic.…”

mentioning

confidence: 99%