Central giant cell granuloma of the mandibular condyle: A rare case and a literature review

Bocchialini, Gabriele; Salvagni, Luana; Guerini, Alice; Castellani, A.

doi:10.1016/j.heliyon.2019.e03085

Cited by 11 publications

(11 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The World Health Organization describes CGCG as a bone lesion [ 4 , 9 , 10 ]. The treatment is controversial ( Table 1 ), and to the best of our knowledge this is the first well-documented case with the longest clinical follow-up treatment of a CGCG in the mandibular condyle described up to now.…”

Section: Discussionmentioning

confidence: 99%

“…Central giant cell granuloma (CGCG) is an intraosseous lesion with three main features: the presence of fibrous connective tissue with multinucleated giant cells, hemorrhagic foci, and bone trabeculation [ 1 , 2 , 3 , 4 ]. It comprises close to 7% of all intraosseous lesions in the jaw; 60% of cases affecting patients under 30 years old, frequently in the anterior area of the mandible [ 5 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Central Giant Cell Granuloma in the Mandibular Condyle in a Teenager. A Case Report with Literature Review

Cantanhede

Olate

Assis³

et al. 2022

JCM

View full text Add to dashboard Cite

Central giant cell granulomas (CGCG) are not common in the mandibular condyle. In teenagers, the problem is more complex because of difficulties in diagnosis and treatment involving the potential growth of the mandibular process and development of the face. In this short communication a case is presented of an eleven-year-old female under diagnosis of central giant cell granuloma affecting the mandibular condyle treated surgically in two steps using a condylectomy and vertical ramus osteotomy at the first time and later orthognathic surgery, showing the clinical evolution after 13 years of follow-up. In addition, we performed a review of the scientific reports related to CGCG in the mandibular condyle to compare this treatment with others, in terms of follow-up and results. We concluded that the CGCG affecting the mandibular head can be properly treated with low condilectomy, vertical mandibular ramus sliding osteotomy, and discopexy.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Central Giant Cell Granuloma in the Mandibular Condyle in a Teenager. A Case Report with Literature Review

Cantanhede

Olate

Assis³

et al. 2022

JCM

View full text Add to dashboard Cite

show abstract

“…In the present study, CGCL showed higher vascular density than PG (control). Central giant cell lesions occur twice as often in the mandible than the maxilla, and commonly in the anterior compared to posterior region (Bocchialini., 2020, Khanna et al, 2018, Whitaker and Waldron, 1993. In addition, giant cell lesions are comprised of fibrocellular stroma with mononuclear cells, characterized by presence of ovoid and spindle shaped cells indicative of the activity and proliferation in the tumor (Chang et al, 2016, Chaparro-Avendao et al, 2005.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Tumor Angiogenesis by Expression of CD 105 in Ameloblastoma, Odontogenic Keratocyst and Central Giant Cell Lesion

Ali

Khan

Sultana

et al. 2020

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

Background: Angiogenesis is critical for tumor growth and reflects the aggressive behavior of invasive odontogenic lesions [like amelogenesis (AM) (AM), Odontogenic Keratocyst (OKC) and Central giant cell lesion (CGCL)]. Mean vascular density (MVD) shows the angiogenic potential and CD105 is an ideal endothelial biomarker due to its specificity to new blood vessels for MVD detection. The aim of the study was to compare the MVD (angiogenic potential) among AM, OKC and CGCL in comparison to Pyogenic Granuloma (PG) using CD105 biomarker. Methods: Sixty-four primary cases of odontogenic invasive tumors (AM, OKC and CGCL) and PG, diagnosed clinically and histologically were included in the study, with 16 samples in each group. Tissue samples of peripheral AM, Peripheral GCL of jaws, malignant AM, and specimen with insufficient tissue were excluded. Tissue sections were embedded, processed and stained using Hematoxylin and Eosin (H and E). Immunohistochemistry was performed using antibodies against CD105, with positive brown cytoplasmic staining in the endothelial cells of neo-vasculature. Distinct countable, positively stained endothelial cell or clusters were evaluated under light microscope for identification of MVD. ANOVA and t-test were applied for statistical analysis of data. Results: Highest MVD was displayed in CGCL (32.99±0.77) and the minimum was observed in OKC (7.21± 0.75) respectively. CGCL showed significantly higher MVD to AM, OKC and PG lesions (p<0.05). AM (8.07± 0.36) and Odontogenic Keratocyst (7.21± 0.75) showed comparable MVD, which was lower than PG (14.7± 0.96) and CGCL vascular density (p < 0.01) respectively. Conclusion: CGCL was most aggressive, with highest MVD among the investigated odontogenic lesions (OKC, AM and PG). The proliferative aggressive behavior of Odontogenic Keratocyst is comparable to AM due to comparable mean vascular density.

show abstract

“…Central giant cell granuloma (CGCG) of the jaws is not a common lesion with only 2270 cases reported in the literature in 2018 [1], the mandibular condyle is seldom affected with only 5 cases reported [2]. The CGCG is more prevalent in females (1.56 females for 1 male), and in young patients with a highest prevalence in the second and third decade of life (mean age of 25.8 years) [1].…”

Section: Introductionmentioning

confidence: 99%

Central giant cell granuloma of the mandibular condyle: additional case and literature review

Marti-Flich

Schlund

Nicot

2022

J Oral Med Oral Surg

View full text Add to dashboard Cite

Introduction: Central giant cell granuloma (CGCG) of the jaws is not a common lesion. Only five cases are reported in the mandibular condyle. Observation: A 25 year-old male presented with preauricular swelling and a premature occlusal contact on the molars. The lesion had radiological features of aggressiveness and a high metabolic uptake. Initial biopsy was misleading. The lesion was treated surgically by resection. Discussion: Histologically, CGCG are very similar to other giant cell lesions such as GCT (Giant cell Tumor) or BTH (brown tumor of hyperparathyroidism). The standard treatment is surgical either by curettage or resection. Only 6 cases have been described in the literature, including this one. The diagnosis is difficult, relying on a bundle of clinical, radiological and histological arguments. However, radical surgery should be performed to avoid the tumor recurrence. The genetic mutations associated with CGCG (notably TRPV4 and RAS pathway) may explain why this tumor is mostly found in the dental part of the jaws and only rarely in the mandibular condyle.

show abstract

Central giant cell granuloma of the mandibular condyle: A rare case and a literature review

Cited by 11 publications

References 15 publications

Central Giant Cell Granuloma in the Mandibular Condyle in a Teenager. A Case Report with Literature Review

Central Giant Cell Granuloma in the Mandibular Condyle in a Teenager. A Case Report with Literature Review

Assessment of Tumor Angiogenesis by Expression of CD 105 in Ameloblastoma, Odontogenic Keratocyst and Central Giant Cell Lesion

Central giant cell granuloma of the mandibular condyle: additional case and literature review

Contact Info

Product

Resources

About