Central depressant activity of butanol fraction of Securinega virosa root bark in mice

Magaji, Mohammed Garba; Yaro, Alpha Seydou; Musa, Abdullahi; Anuka, JA; Aliyu, Ibrahim; Hussaini, Isa M.

doi:10.1016/j.jep.2012.02.010

Cited by 18 publications

(6 citation statements)

References 34 publications

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“…A number of ongoing scientific studies are isolating and characterizing the bioactive principles of the medicinal plants which can serve as “lead” compounds in drug development processes. It is a fact that the vegetal kingdom has been found to be a rich source of bioactive compounds [ 48 ], which are considered members of a specific family of phytochemicals that can interact with multiple targets [ 49 ].…”

Section: Flavonoids With Action In the Cnsmentioning

confidence: 99%

The Role of Flavonoids on Oxidative Stress in Epilepsy

Diniz

Silva

Lima-Saraiva

et al. 2015

Oxidative Medicine and Cellular Longevity

129

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Backgrounds. Oxidative stress can result from excessive free-radical production and it is likely implicated as a possible mechanism involved in the initiation and progression of epileptogenesis. Flavonoids can protect the brain from oxidative stress. In the central nervous system (CNS) several flavonoids bind to the benzodiazepine site on the GABAA-receptor resulting in anticonvulsive effects. Objective. This review provides an overview about the role of flavonoids in oxidative stress in epilepsy. The mechanism of action of flavonoids and its relation to the chemical structure is also discussed. Results/Conclusions. There is evidence that suggests that flavonoids have potential for neuroprotection in epilepsy.

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Section: Flavonoids With Action In the Cnsmentioning

confidence: 99%

The Role of Flavonoids on Oxidative Stress in Epilepsy

Diniz

Silva

Lima-Saraiva

et al. 2015

Oxidative Medicine and Cellular Longevity

129

View full text Add to dashboard Cite

show abstract

“…It is undeniable that the botanical kingdom is a rich source of bioactive chemicals ( Magaji et al, 2012 ). Contemporary scientific research is focused on isolating, identifying, and characterization of the bioactive components of medicinal plants that could be used as “lead” molecules in therapeutic drug discovery and development ( Quintans et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

The antiepileptic potential of Vateria indica Linn in experimental animal models: Effect on brain GABA levels and molecular mechanisms

Alshabi

Shaikh

Asdaq³

2022

Saudi Journal of Biological Sciences

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“…Evaluation of HATW and EATW for their sedative effects, diazepam-induced sleep models was used. [ 9 ] Briefly, Swiss albino mice of either sex were randomly divided into six groups with each group having six mice. The mice were treated with HATW at the dose of 50, 100, 200 mg/kg and EATW (50, 100 mg/kg) body weight or normal saline (10 ml/kg).…”

Section: Methodsmentioning

confidence: 99%

Neuropharmacological activities of Taxus wallichiana bark in Swiss albino mice

Sharma

Garg

2015

Indian J Pharmacol

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Aims:The bark of Taxus wallichiana is widely used for preparing a decoction and consumed as a tea by several tribal communities of the Indian subcontinent. The sedative, motor coordination, anxiolytic, and antidepressant effects of the hydroalcoholic extract of T. wallichiana bark and its ethylacetate fraction were evaluated in mice models of behavior analysis.Materials and Methods:The effects were evaluated on diazepam-induced sleeping time, elevated plus maze and light and dark box, and on the forced swimming test. General locomotor activity and motor coordination effects were evaluated in the actophotmeter and rota-rod tests respectively.Statistical Analysis:Results are expressed as mean ± standard error of the mean. Statistical analysis was performed using ANOVA, followed by post-hoc Dunnett's test. *P < 0.05, **P < 0.01, ***P < 0.001 were considered as significant.Results:Both the hydroalcoholic extract and ethylacetate fraction showed a marked decrease in latency of sleep onset, prolonged the diazepam-induced sleeping time, decreased spontaneous locomotor activity; whereas ethylacetate fraction produced anxiolytic and antidepressant activity.Conclusions:Both hydroalcoholic extract and its ethylacetate fraction of the bark of T. wallichiana have bioactive principles, which induce neuropharmacological changes.

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Central depressant activity of butanol fraction of Securinega virosa root bark in mice

Cited by 18 publications

References 34 publications

The Role of Flavonoids on Oxidative Stress in Epilepsy

The Role of Flavonoids on Oxidative Stress in Epilepsy

The antiepileptic potential of Vateria indica Linn in experimental animal models: Effect on brain GABA levels and molecular mechanisms

Neuropharmacological activities of Taxus wallichiana bark in Swiss albino mice

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