The antiepileptic potential of Vateria indica Linn in experimental animal models: Effect on brain GABA levels and molecular mechanisms

Alshabi, Ali Mohamed; Shaikh, Ibrahim Ahmed; Asdaq, Syed Mohammed Basheeruddin

doi:10.1016/j.sjbs.2022.02.059

Cited by 9 publications

(9 citation statements)

References 39 publications

(41 reference statements)

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“…Throughout the prehistoric era, plants were used as a source of treatment for various diseases worldwide. Numerous undiscovered natural products and nutrients have biologically beneficial properties [ 18 ]. As a result, there is an urgent need to discover and test new treatment alternatives that can effectively be used in disease management while causing minimal side effects.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Silver Nanoparticles from Rhizophora apiculata and Studies on Their Wound Healing, Antioxidant, Anti-Inflammatory, and Cytotoxic Activity

et al. 2022

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Silver nanoparticles (AgNPs) have recently gained interest in the medical field because of their biological features. The present study aimed at screening Rhizophora apiculata secondary metabolites, quantifying their flavonoids and total phenolics content, green synthesis and characterization of R. apiculata silver nanoparticles. In addition, an assessment of in vitro cytotoxic, antioxidant, anti-inflammatory and wound healing activity of R. apiculata and its synthesized AgNPs was carried out. The powdered plant material (leaves) was subjected to Soxhlet extraction to obtain R. apiculata aqueous extract. The R. apiculata extract was used as a reducing agent in synthesizing AgNPs from silver nitrate. The synthesized AgNPs were characterized by UV-Vis, SEM-EDX, XRD, FTIR, particle size analyzer and zeta potential. Further aqueous leaf extract of R. apiculata and AgNPs was subjected for in vitro antioxidant, anti-inflammatory, wound healing and cytotoxic activity against A375 (Skin cancer), A549 (Lung cancer), and KB-3-1 (Oral cancer) cell lines. All experiments were repeated three times (n = 3), and the results were given as the mean ± SEM. The flavonoids and total phenolics content in R. apiculata extract were 44.18 ± 0.086 mg/g of quercetin and 53.24 ± 0.028 mg/g of gallic acid, respectively. SEM analysis revealed R. apiculata AgNPs with diameters ranging from 35 to 100 nm. XRD confirmed that the synthesized silver nanoparticles were crystalline in nature. The cytotoxicity cell viability assay revealed that the AgNPs were less toxic (IC50 105.5 µg/mL) compared to the R. apiculata extract (IC50 47.47 µg/mL) against the non-cancerous fibroblast L929 cell line. Antioxidant, anti-inflammatory, and cytotoxicity tests revealed that AgNPs had significantly more activity than the plant extract. The AgNPs inhibited protein denaturation by a mean percentage of 71.65%, which was equivalent to the standard anti-inflammatory medication diclofenac (94.24%). The AgNPs showed considerable cytotoxic effect, and the percentage of cell viability against skin cancer, lung cancer, and oral cancer cell lines was 31.84%, 56.09% and 22.59%, respectively. R. apiculata AgNPs demonstrated stronger cell migration and percentage of wound closure (82.79%) compared to the plant extract (75.23%). The overall results revealed that R. apiculata AgNPs exhibited potential antioxidant, anti-inflammatory, wound healing, and cytotoxic properties. In future, R. apiculata should be further explored to unmask its therapeutic potential and the mechanistic pathways of AgNPs should be studied in detail in in vivo animal models.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Silver Nanoparticles from Rhizophora apiculata and Studies on Their Wound Healing, Antioxidant, Anti-Inflammatory, and Cytotoxic Activity

et al. 2022

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“… pajurá 106 Seed Native astringent Cytotoxicity, antioxidant, antibacterial [ 57 , 58 ] Dipterocarpaceae Vateria sp. [= Vateria guyanensis *] pau-de-espinhas 104 Seed Exotic Acne treatment with vinegar Wound healing [ 59 ]; antiepileptic [ 60 ]; antioxidant, antidiabetic, cytotoxic [ 61 ] Erythroxylaceae Erythroxylum coca Lam. ipadu, coca 91 Leaf Native Indigenous people chewed to deceive hunger; stimulant and tonic Stimulant † [ 62 , 63 ] Fabaceae Bowdichia virgilioides Kunth sucupiraçu, sucupira pérola 106 Wood, stem bark Native Astringent Wound healing † [ 64 ]; gastric protective agent † [ 65 ]; antihyperglycemic [ 66 ]; antinociceptive [ 67 , 68 ]; anti-inflammatory [ 68 ] Cassia grandis L.f. (= Cassia brasiliana Lam.)…”

Section: Resultsmentioning

confidence: 99%

Amazonian useful plants described in the book “Le Pays des Amazones” (1885) of the Brazilian propagandist Baron de Santa-Anna Nery: a historical and ethnobotanical perspective

Silva,

Oliveira,

Baratto

2024

J Ethnobiology Ethnomedicine

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Background Frederico José de Santa-Anna Nery (1848–1901) was a Brazilian Baron who referred to himself as a "volunteer propagandist" for Brazil in Europe, serving as an immigration agent to publicize the living conditions in the Amazon region, advocating for its development and modernization at the end of the nineteenth century. Santa-Anna Nery’s most famous book is "Le Pays des Amazones" (The Lands of the Amazons), first published in 1885, which the author dedicated a chapter to introduce and report on the Amazonian useful plant species and its relationship with humans. The aim of this work is to understand the historical context and ethnobotanical value of the plant species in the Brazilian Amazon at the end of the nineteenth century through an analysis of the book “Le Pays des Amazones” (1885) by Baron de Santa-Anna Nery, as well as to bring to light the historical importance of this very influential propagandist, who has been forgotten nowadays. Methods The original book “Le Pays des Amazones” (1885), as well as the original 3rd edition and its translated version into Portuguese, was carefully analyzed and all information about plants was systematized, with botanical names being updated. Finally, using the scientific name of medicinal plants alone or in combination with their traditional use, a search was carried out in databases in order to indicate current pharmacological studies that provide evidence about the described traditional uses. Results A total of 156 plant species were identified in the book, although 132 species had their scientific names updated. These species belong to 45 different families, with Fabaceae and Arecaceae the most represented, and 109 plants are Brazilian native. Considering only the 36 medicinal plants, the main medicinal indications reported were astringent, purgative/laxative, stimulant and tonic, vermifuge, febrifuge, sudorific, emetic, diuretic and antidysenteric. Regarding other useful plants (non-medicinal), 97 species were cited for food, constructions and buildings, spices and condiments, ornaments and objects, carpentry, textile fibers, gums, oils, balms and essences, pigments and tanning, hunting and fishing. Conclusions When the book “Le Pays des Amazones” is analyzed from a timeless perspective, with a particular focus on historical ethnobotany, it is possible to observe the economic, social, and political importance of many useful plants for the Amazon at the end of the nineteenth century and how the relationship between local people, indigenous communities, and immigrants was established with plant biodiversity.

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“…It affects more than 50 million people worldwide, kills 125,000 people each year, and is the sixth leading cause of disability worldwide; more than 85% of cases occur in low-income populations. As a result, it has a detrimental influence on health outcomes while also increasing healthcare expenses and the psychological, cognitive, social, and economic burden [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…The most common epilepsy, attributable to approximately 60% of all epileptic patients, is temporal lobe epilepsy, with nearly 30% of patients refractory to conventional pharmacological therapy [ 1 , 13 ]. Additionally, none of the anticonvulsants currently on the market work to resolve co-morbidities or the underlying pathophysiology of epilepsy; they merely treat the symptoms of epilepsy [ 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, none of the anticonvulsants currently on the market work to resolve co-morbidities or the underlying pathophysiology of epilepsy; they merely treat the symptoms of epilepsy [ 14 , 15 , 16 ]. Furthermore, they have a lot of side effects, such as congenital anomalies, sedation, hepatotoxicity, agranulocytosis, colitis, drowsiness, and dizziness, and patients with epilepsy are more vulnerable to the side effects of anti-epileptic drugs, which are assumed to be due to structural or functional abnormalities [ 1 , 17 , 18 ]. Thus, more innovative disease-modifying medicines with really curative effects on epilepsy and safety are required while avoiding substantial side effects, particularly sedation, and medicinal plants are a source for producing more effective medications [ 12 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Ameliorative Potential of (-) Pseudosemiglabrin in Mice with Pilocarpine-Induced Epilepsy: Antioxidant, Anti-Inflammatory, Anti-Apoptotic, and Neurotransmission Modulation

Balaha

Alamer

Abdel-Kader

et al. 2023

IJMS

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One prevalent neurological disorder is epilepsy. Modulating GABAergic/glutamatergic neurotransmission, Nrf2/HO-1, PI3K/Akt, and TLR-4/NF-B pathways might be a therapeutic strategy for epilepsy. Eight-week-old BALB/c mice were administered 12.5, 25, or 50 mg/kg (-) pseudosemiglabrin orally one hour before inducing epilepsy with an i.p. injection of 360 mg/kg pilocarpine. (-) Pseudosemiglabrin dose-dependently alleviated pilocarpine-induced epilepsy, as revealed by the complete repression of pilocarpine-induced convulsions and 100% survival rate in mice. Furthermore, (-) pseudosemiglabrin significantly enhanced mice’s locomotor activities, brain GABA, SLC1A2, GABARα1 levels, glutamate decarboxylase activity, and SLC1A2 and GABARα1mRNA expression while decreasing brain glutamate, SLC6A1, GRIN1 levels, GABA transaminase activity, and SLC6A1 and GRIN1 mRNA expression. These potentials can be due to the suppression of the TLR-4/NF-κB and the enhancement of the Nrf2/HO-1 and PI3K/Akt pathways, as demonstrated by the reduction in TLR-4, NF-κB, IL-1β, TNF-α mRNA expression, MDA, NO, caspase-3, Bax levels, and Bax/Bcl-2 ratio, and the enhancement of Nrf2, HO-1, PI3K, Akt mRNA expression, GSH, Bcl-2 levels, and SOD activity. Additionally, (-) pseudosemiglabrin abrogated the pilocarpine-induced histopathological changes. Interestingly, the (-) pseudosemiglabrin intervention showed a comparable effect to the standard medication, diazepam. Therefore, (-) pseudosemiglabrin can be a promising medication for the management of epilepsy.

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The antiepileptic potential of Vateria indica Linn in experimental animal models: Effect on brain GABA levels and molecular mechanisms

Cited by 9 publications

References 39 publications

Synthesis and Characterization of Silver Nanoparticles from Rhizophora apiculata and Studies on Their Wound Healing, Antioxidant, Anti-Inflammatory, and Cytotoxic Activity

Synthesis and Characterization of Silver Nanoparticles from Rhizophora apiculata and Studies on Their Wound Healing, Antioxidant, Anti-Inflammatory, and Cytotoxic Activity

Amazonian useful plants described in the book “Le Pays des Amazones” (1885) of the Brazilian propagandist Baron de Santa-Anna Nery: a historical and ethnobotanical perspective

Ameliorative Potential of (-) Pseudosemiglabrin in Mice with Pilocarpine-Induced Epilepsy: Antioxidant, Anti-Inflammatory, Anti-Apoptotic, and Neurotransmission Modulation

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