Central corneal thickness, lamina cribrosa and peripapillary scleral histomorphometry in non-glaucomatous chinese eyes

Ren, Ruojin; Li, Bin; Gao, Fei; Li, Liao-qing; Xu, Xiaolin; Wang, Ke; Jonas, Jost B.

doi:10.1007/s00417-010-1369-y

Cited by 28 publications

(12 citation statements)

References 28 publications

(36 reference statements)

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“…The fact that we have patients with moderate to advanced disease stage on average in our study possibly explains the CCT difference between groups. It is important to emphasize that this fact probably did not influence our results, as previous studies have not found any relationship between CCT and LC parameters [29,30]. Second, our results apply solely to this specific study population, and should not be extrapolated to glaucomatous patients with different characteristics.…”

Section: Discussionmentioning

confidence: 70%

In vivo analysis of glaucoma-related features within the optic nerve head using enhanced depth imaging optical coherence tomography

et al. 2017

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Structural differences between optic nerve head (ONH) parameters in glaucomatous and non-glaucomatous eyes has been documented, however the association between such parameters in patients with different disease stages is yet to be elucidated. We investigated the relationship between different laminar and prelaminar ONH structures using enhanced depth imaging spectral-domain optical coherence tomography (EDI OCT) in a population with and without glaucoma. In this observational case-control study, we prospectively enrolled healthy individuals and glaucomatous patients with different disease stages. All participants underwent EDI OCT imaging (Heidelberg Engineering). Following ONH parameters were measured on serial vertical B-scans by two examiners masked to patient’s clinical data: lamina cribrosa (LC) and prelaminar neural tissue (PLNT) thicknesses, Bruch’s membrane opening (BMO) and cup depth. Associations between cup depth, and laminar and prelaminar parameters were evaluated controlling for possible confounding factors such as axial length and disc size. Sixty-four eyes of 64 patients were included (30 with glaucoma and 34 controls). Eyes with glaucoma had significantly lower mean LC and PLNT thickness, and greater mean cup depth than controls (p<0.01). There was a significant negative association between PLNT thickness and cup depth in glaucomatous eyes (R2 = 0.158, p = 0.029). In addition, LC thickness correlated significantly with cup depth (R2 = 0.135, p = 0.045). Eyes with thinner LCs presented deeper cups. Overall, cup depth and BMO had the best and LC thickness had the worst intraobserver and interobserver reproducibility grading. In conclusion, significant associations were seen between cup depth, LC and PLNT thickness. Eyes with deeper cups not only had less neural tissue, but also thinner LCs, independent of disc size and axial length. Best reproducibility was found for prelaminar parameters compared to deeper ONH structures.

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Section: Discussionmentioning

confidence: 70%

In vivo analysis of glaucoma-related features within the optic nerve head using enhanced depth imaging optical coherence tomography

et al. 2017

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“…11,22,23 For this reason, this device has been used in the current series for evaluating and comparing the anterior and posterior corneal elevation data in eyes with POAG and healthy control subjects. 27,28 Another explanation for our findings could be that the elevation topography and the corneal thickness, in previously normal corneas, do change during the course of the glaucomatous disease, and that this change could be caused by the effect of elevated IOP on the cornea, which may cause mechanical distortion 12 similarly to the IOP-induced mechanical stress observed at the level of the lamina cribrosa. In addition, there were also significant differences, although minimal in magnitude, between glaucomatous and healthy corneas regarding anterior surface elevation.…”

Section: Discussionmentioning

confidence: 79%

Orbscan Topography in Primary Open-Angle Glaucoma

Arranz-Marquez

Bolívar²,

Piñero³

et al. 2013

Optometry and Vision Science

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“…The disparity may be explained by the duration and severity of glaucoma, which could influence the compliance of the lamina in response to IOP changes [54]. Other studies have found no relationship between CCT and the LC [55,56].…”

Section: Biological Factorsmentioning

confidence: 96%

The thick and thin of the central corneal thickness in glaucoma

Belovay

Goldberg

2018

Eye

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Central corneal thickness (CCT) is an important parameter in the assessment of any potential glaucoma patient. While it affects prognosis in ocular hypertension, its value in patients diagnosed with glaucoma is less certain. There are several biological factors and genetic components that may influence glaucoma progression, which have been associated with thinner CCT. The CCT itself can be affected by several factors including ethnicity, age, sex, glaucoma medications, genetics, and the subtype of glaucoma. Besides, there is variability in the measurement of CCT between difference types of devices. These factors need to be considered in the evaluation of glaucoma patients' CCT and its effect on interpretation of intraocular pressure levels and risk stratification.

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Central corneal thickness, lamina cribrosa and peripapillary scleral histomorphometry in non-glaucomatous chinese eyes

Cited by 28 publications

References 28 publications

In vivo analysis of glaucoma-related features within the optic nerve head using enhanced depth imaging optical coherence tomography

In vivo analysis of glaucoma-related features within the optic nerve head using enhanced depth imaging optical coherence tomography

Orbscan Topography in Primary Open-Angle Glaucoma

The thick and thin of the central corneal thickness in glaucoma

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