Orbscan Topography in Primary Open-Angle Glaucoma

Arranz-Marquez, Esther; Bolívar, Gema; Piñero, David P.; Konstas, Anastasios G. P.; Mikropoulos, Dimitrios G.; Teus, Miguel A.

doi:10.1097/opx.0000000000000019

Cited by 7 publications

(3 citation statements)

References 31 publications

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“…Even though it was not initially the main purpose of the study, we found a significant correlation between the nonmedicated mean IOP and the PCE at the preoperative baseline visit, suggesting that mechanical compression of the stroma occurs in POAG eyes with a subsequent increase in the PCE. This finding, which could be a new marker for the biomechanical corneal modifications that occur in glaucoma patients, has been previously described by Arranz-Marquez et al 26 Most likely, corneal hysteresis (CH) and the way it responds to changes in the IOP are involved in the changes encountered in the PCE. CH remains stable with diurnal variations in the IOP 27 or transient corneal swelling induced by contact lenses, 28 thus maintaining biomechanical integrity under these conditions.…”

Section: Discussionsupporting

confidence: 73%

Changes to Corneal Topography and Biometrics After PRESERFLO Microshunt Surgery for Glaucoma

Barberá¹,

Morales-Fernández

Liaño

et al. 2021

Journal of Glaucoma

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Precis: Glaucoma surgery with PRESERFLO Microshunt shows mild and transient changes in the corneal astigmatism, corneal elevation and biometrics in the early postoperative period. Posterior corneal elevation (PCE) tends to be higher in primary open angle glaucoma (POAG). Purpose:The aim was to determine the changes in the corneal keratometry, astigmatism and elevation, refraction, axial length (AL) and anterior chamber depth and volume after the implantation of the PRESERFLO Microshunt in patients with POAG in the early postoperative period.Patients and Methods: Patients diagnosed with POAG who underwent an ab externo (polystyrene-block-isobutylene-block-styrene) microshunt implantation were recruited. The central corneal thickness, the intraocular pressure (IOP), best-corrected visual acuity, refraction, biometrics, and corneal topography with a Scheimpflug topographer were analyzed preoperatively and 24 hours, 1 week, 1 month, and 3 months after surgery.Results: A total of 30 eyes of 29 patients were included. In 24 eyes the device was implanted as a stand-alone procedure and in 6 eyes it was combined with cataract surgery. The results were analyzed separately. The IOP decreased from 21.8 ± 5.2 and 16.5 ± 1.5 mm Hg at baseline to 10.9 ± 1.8 and 10.1 ± 1.1 mm Hg at 3 months in the noncombined and combined groups (P < 0.01). The anterior surface astigmatism, posterior surface astigmatism, and total corneal astigmatism increased in each group 0.4 ± 0.3/0.2 ± 1.0 D, 0.08 ± 0.1/ 0.03 ± 0.1 D and 0.4 ± 0.3/0.2 ± 0.9 D, respectively, at 3 months. The anterior corneal elevation and PCE (ACE max, ACE min, PCE max) increased in the first week (P = 0.01) with no significant changes at 3 months in the noncombined group. The changes observed in the combined group were not significant. The AL decreased to 0.13 ± 0.23 and 0.2 ± 0.07 mm in each group (P = 0.01). There was a significant correlation between the IOP and the maximum elevation of the posterior surface of the cornea at the preoperative examination (r = 0.93, P = 0.02). Conclusions:The PRESERFLO Microshunt implant for glaucoma surgery induces mild and transient changes in corneal astigmatism, AL and anterior chamber depth in the early postoperative period.

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Section: Discussionsupporting

confidence: 73%

Changes to Corneal Topography and Biometrics After PRESERFLO Microshunt Surgery for Glaucoma

Barberá¹,

Morales-Fernández

Liaño

et al. 2021

Journal of Glaucoma

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“…Therefore, we can conclude that CCT values differ between populations and genders. These facts should be considered when performing applanation tonometry and refractive surgery [ 4 , 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Do Gender, Age, Body Mass and Height Influence Eye Biometrical Properties in Young Adults? A Pilot Study

Kolačko

Predović

Kokot

et al. 2021

IJERPH

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Background: Do gender, age, body mass and height influence eye biometrical properties in young adults? Methods: A total of 155 eyes (92 female, 63 male) of healthy subjects between the ages of 18 and 39 years were included in the study. The subjects’ gender and age were recorded, and their body mass, height and biometrical properties of the eyes were measured. Results: The male subjects had significantly thicker and flatter corneas and lower minimal rim-to-disk ratios than the female subjects did. In both genders, age showed strong, negative correlations with anterior chamber depth and pupil diameter and a positive correlation with lens thickness. We also found significant, negative correlations between body height and mass with keratometry measurements, negative correlations between body height and optic disk rim area and rim volume, and positive correlations between body mass and axial length in both genders. Conclusions: Biometric eye parameters differ among people. In addition to age and gender, which are usually taken into consideration when interpreting ocular biometry findings, we strongly suggest that body height and mass should be also routinely considered when interpreting eye biometry data, as these factors have an impact on ocular biometry.

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“…Furthermore, glaucoma can modify the cornea. The posterior corneal surface is more elevated in patients with glaucoma than in healthy subjects [6], lowering the IOP in steroid-induced glaucoma decreases the posterior corneal elevation and the CCT [7] and IOP elevation produces refractive changes in patients who underwent a previous corneal laser refractive surgery [8].…”

Section: Introductionmentioning

confidence: 99%

Effect of Acute Increases in Intraocular Pressure on Corneal Pachymetry in Rabbit Eyes Treated with Timolol Maleate

Sánchez-Barahona¹,

Bolívar²,

Mikropoulos³

et al. 2018

TOOPHTJ

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Objective: To evaluate in an in vivo rabbit model, the effect of topical timolol maleate therapy on the central corneal thickness response to acute intraocular pressure increases. Method: In this prospective and interventional controlled study, the central corneal thickness and intraocular pressure were measured in vivo in 12 rabbit eyes treated with topical timolol maleate for 1 month and in 12 controls at baseline, and after the intraocular pressure (measured by direct cannulation of the anterior chamber) was increased to 15 and 30 mmHg using a forced saline infusion into the anterior chamber. Results: There were no significant differences in the basal central corneal thickness values (control group, 373.2±12.9 µm; study group, 377.5±19.2 µm, p=0.5) or the central corneal thickness values when the intraocular pressure was increased to 15 mmHg (control group, 335.2±14.3 µm; study group, 330.0±32.1 µm, p=0.6) and to 30 mmHg (study group, 318.8±25.3 µm; control group, 329.8±21.0 µm, p=0.3). Conclusion: Rabbit corneas treated with topical timolol maleate for 1 month did not show a strain response to acute intraocular pressure increases that differed from control eyes. This is in contrast to a previous finding in which rabbit eyes treated with prostaglandin analogues had a greater decrease in central corneal thickness in response to a sudden intraocular pressure increase compared with untreated corneas.

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Orbscan Topography in Primary Open-Angle Glaucoma

Abstract: Primary open-angle glaucoma eyes have a higher elevation of the posterior corneal surface than that in central corneal thickness-matched nonglaucomatous eyes.

Cited by 7 publications

References 31 publications

Changes to Corneal Topography and Biometrics After PRESERFLO Microshunt Surgery for Glaucoma

Changes to Corneal Topography and Biometrics After PRESERFLO Microshunt Surgery for Glaucoma

Do Gender, Age, Body Mass and Height Influence Eye Biometrical Properties in Young Adults? A Pilot Study

Effect of Acute Increases in Intraocular Pressure on Corneal Pachymetry in Rabbit Eyes Treated with Timolol Maleate

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