Central Corneal Thickness and Corneal Hysteresis Associated With Glaucoma Damage

Congdon, Nathan; Broman, Aimee Teo; Bandeen‐Roche, Karen; Grover, Davinder S.; Quigley, Harry A.

doi:10.1016/j.ajo.2005.12.007

Cited by 460 publications

(406 citation statements)

References 34 publications

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“…CH is lower in glaucoma damage, acquired optic nerve pitting, and progressive glaucoma. 2,15,[28][29][30][31] In glaucoma patients with low hysteresis, there is greater backward bowing of the lamina cribrosa in response to transient IOP elevation. 32 Furthermore, CH measurements may be useful in identifying patients with keratoconus and post-LASIK ectasia, as well as for monitoring biomechanical corneal properties before and after keratorefractive procedures.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of agreement between intraocular pressure measurements using Goldmann applanation tonometry and Goldmann correlated intraocular pressure by Reichert's ocular response analyser

Ehrlich

Haseltine

Shimmyo

et al. 2010

Eye

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Purpose To compare agreement of intraocular pressure (IOP) measurements using Goldmann applanation tonometry (GAT) and Goldmann correlated intraocular pressure generated (IOPg) by the Reichert ocular response analyser (ORA). Methods Consecutive patients presenting for glaucoma evaluation underwent ORA assessment followed by examination including GAT. For each ORA assessment, measurements were taken until a waveform score (WS) of 6.5 was obtained or until five measurements were obtained per eye. The relationship between GAT and IOPg and the influence of the WS upon this relationship was evaluated. A Bland-Altman plot and linear regression were used to determine agreement between GAT and IOPg. Results A total of 518 eyes of 260 patients were included in the final analysis. Increasing WS was found to predict a smaller difference between GAT and IOPg (b ¼ À0.2, Pp0.001). Selecting the highest WS among ORA assessments of each eye, WS continued to predict concordance between GAT and IOPg (b ¼ À0.2, P ¼ 0.006). The mean IOP difference between methods was 0.1 mm Hg (±0.3), which was found to be statistically insignificant (P ¼ 0.391). This relationship between GAT and IOPg was successfully validated using a second distinct data set of 100 eyes. GAT and IOPg measurements varied by 2 mm Hg or less in 53.9% of eyes and 5 mm Hg or less in 92.3% of eyes. Conclusion In clinical practice IOPg is strongly related to GAT. Although higher WS is indicative of greater IOPg/GAT concordance, its influence is minimal. This study does not support the use of a specific WS cutoff to determine quality of an IOPg measurement.

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Section: Discussionmentioning

confidence: 99%

“…1,2 As IOP reduction is the mainstay of treatment, accurate IOP assessment is important in monitoring the efficacy of therapy and for assessing the risk of glaucomatous progression. [3][4][5][6] Goldmann applanation tonometry (GAT) is currently the clinical gold standard for IOP assessment.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of agreement between intraocular pressure measurements using Goldmann applanation tonometry and Goldmann correlated intraocular pressure by Reichert's ocular response analyser

Ehrlich

Haseltine

Shimmyo

et al. 2010

Eye

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“…O estudo identificou que histerese mais baixa era um importante fator de predição de piora dos parâmetros perimétricos (15) .…”

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Estudo das correlações entre a área do disco óptico e as características geométricas e biomecânicas da córnea

Silva¹,

Silva²,

Lima³

et al. 2011

Rev. bras.oftalmol.

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RESUMOObjetivo: Correlacionar área do disco óptico com parâmetros geométricos e biomecânicos da córnea. Métodos: Estudo retrospectivo nos arquivos de pacientes do Instituto de Olhos Renato Ambrósio a fim de se identificar os pacientes que realizaram exames HRT (Heidelberg Retina Tomography), Pentacam e ORA. A retinografia digital foi revisada de modo a se classificar na escala DDLS (Disc Damage Likelihood Scale).Resultados: 244 olhos de 122 pacientes (75 mulheres) foram incluídos no estudo. A média de idade foi de 47,2 anos (de 8 a 97 anos, desvio padrão de 21,7). Não houve correlação significante entre área do disco e nenhuma das medidas de PIO (IOPg, IOPcc). Encontrou-se uma relação negativa significativa com CRF (r=-0,1337, p=0,0263). A relação com histerese foi também negativa (-0,1123), mas o valor p foi maior que 0,05 (0,0625). Não houve correlação significante entre área do disco e progressão paquimétrica mínima ou média. Entretanto, observou-se correlação significante e positiva entre a área do disco e astigmatismo corneano (Delta K), sendo de 1,15 (p=0,0129). Conclusão: Existe uma correlação negativa entre a área do disco óptico e os parâmetros biomecânicos e estruturais da córnea. Tal correlação pode ser parte da explicação da córnea ser um fator de risco para maior susceptibilidade do nervo óptico para neuropatia glaucomatosa.

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“…6,[22][23][24][25][26] Previous studies have suggested that systemic and ocular factors, such as ageing, [27][28][29] chronically elevated IOP, [30][31][32] level of glaucomatous damage, 1,17,33 and disc size (scleral canal diameter), 34 could influence the susceptibility of an individual ONH to a given level of IOP. More recently, it has been suggested that other factors could be either directly or indirectly related to ONH response to pressure-induced damage, such as corneal parameters (both CCT and CH) 13,[35][36][37] and diabetes.…”

Section: Introductionmentioning

confidence: 99%

“…13 Susceptibility to glaucomatous damage varies among patients and seems to be related to several individual ocular and systemic characteristics. Although some factors such as age 1,[14][15][16] and central corneal thickness (CCT) are better established, 1,14,16 others such as corneal hysteresis (CH) 17 and diabetes mellitus (DM) 11,[18][19][20][21] remain controversial.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with topographic changes of the optic nerve head induced by acute intraocular pressure reduction in glaucoma patients

Prata

Lima

Moraes

et al. 2010

Eye

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Purpose To investigate factors associated with changes in optic nerve head (ONH) topography after acute intraocular pressure (IOP) reduction in patients with primary open-angle glaucoma (POAG). Methods Untreated POAG patients (IOP 421 mm Hg) were prospectively enrolled. Systemic and ocular information were collected, including central corneal thickness (CCT) and corneal hysteresis (CH). All patients underwent confocal scanning laser ophthalmoscopy and tonometry (Goldmann) before and 1 h after pharmacological IOP reduction. The mean of three measurements was considered for analysis. Changes in each ONH topographic parameter were assessed (one eye was randomly selected), and those that changed significantly were correlated with patient's systemic and ocular characteristics. Results A total of 42 patients were included (mean age, 66.7 ± 11.8 years). After a mean IOP reduction of 47.3±11.9%, significant changes were observed in cup area and volume, and in rim area and volume (Po0.01), but not in mean cup depth (P ¼ 0.80). Multiple regression analysis (controlling for baseline IOP and magnitude of IOP reduction) showed that CH (r 2 ¼ 0.17, Po0.01) and diabetes diagnosis (r 2 X0.21, Po0.01) were negatively correlated with the magnitude of changes in ONH parameters, whereas the cup-to-disc ratio was positively correlated (r 2 ¼ 0.30, Po0.01). Age, race, disc area, and CCT were not significant (PX0.12). Including all significant factors in a multivariable model, only the presence of diabetes remained significantly associated with all ONH parameters evaluated (Po0.01). Conclusions Different systemic and ocular factors, such as diabetes, CH, and the relative size of the cup, seem to be associated with the magnitude of changes in ONH topography after acute IOP reduction in POAG patients. These associations partially explain the ONH changes observed in these patients and suggest that other factors are possibly implicated in an individual susceptibility to IOP.

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Central Corneal Thickness and Corneal Hysteresis Associated With Glaucoma Damage

Cited by 460 publications

References 34 publications

Evaluation of agreement between intraocular pressure measurements using Goldmann applanation tonometry and Goldmann correlated intraocular pressure by Reichert's ocular response analyser

Evaluation of agreement between intraocular pressure measurements using Goldmann applanation tonometry and Goldmann correlated intraocular pressure by Reichert's ocular response analyser

Estudo das correlações entre a área do disco óptico e as características geométricas e biomecânicas da córnea

Factors associated with topographic changes of the optic nerve head induced by acute intraocular pressure reduction in glaucoma patients

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