Central Cholinergic Dysfunctions in Man: Clinical Manifestations and Approaches to Diagnosis and Treatment

Schuberth, Jan

doi:10.1007/978-1-4684-3096-7_50

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Deanol1

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1982

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Cited by 4 publications

(1 citation statement)

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“…Neither single nor repeated administration of deanol altered the concentration of ACh in corpus striatum, hippocampus or cortex, in agreement with the results of Pepeu et al, (1960) and Zahniser et aI., (1977). Deanol did increase the concentration of Ch in the plasma and brain after both single and repeated doses of deanol, as others have also found (Dahlberg and Schuberth, 1977;Schuberth, 1977;Zahniser, 1977). The mechanism of this effect remains to be investigated.…”

Section: Deanolmentioning

confidence: 53%

The Neurochemical Basis of Acetylcholine Precursor Loading as a Therapeutic Strategy

Jenden

1979

Brain Acetylcholine and Neuropsychiatric Disease

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Section: Deanolmentioning

confidence: 53%

The Neurochemical Basis of Acetylcholine Precursor Loading as a Therapeutic Strategy

Jenden

1979

Brain Acetylcholine and Neuropsychiatric Disease

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Central cholinergic involvement in behavioral hyper-reactivity

Russell

Macri

1979

Pharmacology Biochemistry and Behavior

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Cholinergic regulation of mood and REM sleep: potential model and marker of vulnerability to affective disorder

1982

AJP

219

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To test the hypothesis that depression and REM sleep share common cholinergic mechanisms the authors administered arecoline 25 min after completion of the first REM period to 14 patients with remitted bipolar affective disorder, 15 normal controls, and 5 subjects with a personal or family history of affective disorder. The second REM period occurred significantly sooner in the remitted patients than in the normal controls. The patients also had a significantly higher density of eye movements during the first REM period and a higher percentage of REM sleep. The authors believe that increased cholinergic sensitivity and REM density may be biological markers of increased vulnerability to bipolar affective illness.

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Central Cholinergic Dysfunctions in Man: Clinical Manifestations and Approaches to Diagnosis and Treatment

Cited by 4 publications

References 61 publications

The Neurochemical Basis of Acetylcholine Precursor Loading as a Therapeutic Strategy

The Neurochemical Basis of Acetylcholine Precursor Loading as a Therapeutic Strategy

Central cholinergic involvement in behavioral hyper-reactivity

Cholinergic regulation of mood and REM sleep: potential model and marker of vulnerability to affective disorder

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