Central auditory processing in patients with spinocerebellar ataxia

Zeigelboim, Bianca Simone; Carvalho, Hugo Amilton Santos de; Teive, Hélio Afonso Ghizoni; Liberalesso, Paulo Breno Noronha; Jurkiewicz, Ari Leon; Abdulmassih, Edna Márcia da Silva; Marques, Jair Mendes; Cordeiro, Mara L.

doi:10.1016/j.heares.2015.07.006

Cited by 9 publications

(9 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, cerebellar monitoring appears to be an increase in the function of attention as opposed to an automatic monitoring process (Allen et al, 1997 ). Cerebellar damage is linked to impaired internal predictions for motor responses, at least in the visual domain (Therrien and Bastian, 2015 ), and individuals with spinocerebellar ataxia are likely to have difficulty with auditory integration and temporal gap detection (Zeigelboim et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Decreased Cerebellar-Orbitofrontal Connectivity Correlates with Stuttering Severity: Whole-Brain Functional and Structural Connectivity Associations with Persistent Developmental Stuttering

Sitek

Cai

Beal

et al. 2016

Front. Hum. Neurosci.

View full text Add to dashboard Cite

Persistent developmental stuttering is characterized by speech production disfluency and affects 1% of adults. The degree of impairment varies widely across individuals and the neural mechanisms underlying the disorder and this variability remain poorly understood. Here we elucidate compensatory mechanisms related to this variability in impairment using whole-brain functional and white matter connectivity analyses in persistent developmental stuttering. We found that people who stutter had stronger functional connectivity between cerebellum and thalamus than people with fluent speech, while stutterers with the least severe symptoms had greater functional connectivity between left cerebellum and left orbitofrontal cortex (OFC). Additionally, people who stutter had decreased functional and white matter connectivity among the perisylvian auditory, motor, and speech planning regions compared to typical speakers, but greater functional connectivity between the right basal ganglia and bilateral temporal auditory regions. Structurally, disfluency ratings were negatively correlated with white matter connections to left perisylvian regions and to the brain stem. Overall, we found increased connectivity among subcortical and reward network structures in people who stutter compared to controls. These connections were negatively correlated with stuttering severity, suggesting the involvement of cerebellum and OFC may underlie successful compensatory mechanisms by more fluent stutterers.

show abstract

Section: Discussionmentioning

confidence: 99%

Decreased Cerebellar-Orbitofrontal Connectivity Correlates with Stuttering Severity: Whole-Brain Functional and Structural Connectivity Associations with Persistent Developmental Stuttering

Sitek

Cai

Beal

et al. 2016

Front. Hum. Neurosci.

View full text Add to dashboard Cite

show abstract

“… T Frontotemporal dementia with inclusion body myositis, Paget’s disease of bone VCP mutations Niemann-Pick type C [ 120 ] F; RC T c Ataxia, supranuclear gaze palsy, dystonia, psychiatric features, cataplexy, seizures, splenomegaly Skin fibroblast studies (accumulation of unesterified cholesterol), genotyping Oculo-leptomeningeal amyloidosis [ 121 ] F; RC? a F Seizures, stroke-like episodes, headache, ataxia, myelo-radiculopathy, subarachnoid haemorrhage, ocular amyloid Abnormal meningeal enhancement on contrast MRI Transthyretin mutations Refsum disease [ 122 ] F; RC U Retinitis pigmentosa, anosmia, polyneuropathy Raised plasma phytanic acid PHYH mutation Spinocerebellar ataxias: [ 83 ] F; C, RC i F Truncal/limb ataxia, bulbar deficits, proprioceptive impairment, neuropathy, variably prominent across group Various mutations (most frequently, trinucleotide repeat expansions) Friedreich’s ataxia [ 123 ] Cardiomyopathy, diabetes mellitus (adult onset milder) FXN expansions SCA13 [ 124 ] Gait/limb ataxia, dysarthria, hyperreflexia, vibration sense loss KCNC3 mutations Wolfram’s syndrome [ 125 ] T; RC F j Optic atrophy, diabetes WFS1 mutations Other Prion diseases [ 126 ] U; RC T Rapi...…”

Section: Hearing Loss and Dementiamentioning

confidence: 99%

Hearing and dementia

et al. 2016

View full text Add to dashboard Cite

Hearing deficits associated with cognitive impairment have attracted much recent interest, motivated by emerging evidence that impaired hearing is a risk factor for cognitive decline. However, dementia and hearing impairment present immense challenges in their own right, and their intersection in the auditory brain remains poorly understood and difficult to assess. Here, we outline a clinically oriented, symptom-based approach to the assessment of hearing in dementias, informed by recent progress in the clinical auditory neuroscience of these diseases. We consider the significance and interpretation of hearing loss and symptoms that point to a disorder of auditory cognition in patients with dementia. We identify key auditory characteristics of some important dementias and conclude with a bedside approach to assessing and managing auditory dysfunction in dementia.

show abstract

“…However, according to another approach, similar patterns of sensorineural hearing loss (slightly worse in the PD group) were observed when comparing the control group and PD patients, which were typical for their age [ 29 ]. Auditory dysfunction is also shown in Huntington’s disease, diseases linked to the cerebellum, such as spinocerebellar ataxias, and Friedreich’s ataxia [ 30 31 32 33 ].…”

Section: Resultsmentioning

confidence: 99%

“…A large number of studies have demonstrated an association between hearing loss and neurodegenerative diseases [21][22][23][24][25][26][27][28][29][30][31][32][33]. Hearing loss is a risk marker for cognitive decline and dementia [23].…”

Section: Hearing Impairment and Neurodegenerative Diseasesmentioning

confidence: 99%

Auditory and Olfactory Deficits in Essential Tremor – Review of the Current Evidence

Şengül

2020

Tremor and Other Hyperkinetic Movements

View full text Add to dashboard Cite

Background: Essential tremor (ET) is the most common adult movement disorder, characterized by several motor and increasingly well recognized non-motor symptoms. Sensory deficits, such as hearing impairment and olfactory dysfunction, are amongst them. This review analyzes the available evidence of these sensory deficits and their possible mechanistic basis in patients with ET. Method: A PubMed literature search on the topic was performed in the May 2019 database. Results: Nineteen articles on hearing impairment and olfactory dysfunction in ET patients were identified. The prevalence of hearing impairment is higher in ET patients than healthy controls or Parkinson disease. Cochlear pathologies are suggested as the underlying cause, but there is still a lack of information about retrocochlear pathologies and central auditory processing. Reports on olfactory dysfunction have conflicting results. The presence of mild olfactory dysfunction in ET was suggested. Conflicting results may be due to the lack of consideration of the disease's heterogeneity, but according to recent data, most studies do not find prominent evidence of olfactory loss in ET. Conclusion: Although there is increasing interest in studies on non-motor symptoms in ET, there are few studies on sensory deficits, which are of particularly high prevalence. More studies are needed on to investigate the basis of non-motor symptoms, including sensory deficits.

show abstract

Central auditory processing in patients with spinocerebellar ataxia

Cited by 9 publications

References 47 publications

Decreased Cerebellar-Orbitofrontal Connectivity Correlates with Stuttering Severity: Whole-Brain Functional and Structural Connectivity Associations with Persistent Developmental Stuttering

Decreased Cerebellar-Orbitofrontal Connectivity Correlates with Stuttering Severity: Whole-Brain Functional and Structural Connectivity Associations with Persistent Developmental Stuttering

Hearing and dementia

Auditory and Olfactory Deficits in Essential Tremor – Review of the Current Evidence

Contact Info

Product

Resources

About