Cellulose-Based Hydrogels in Tissue Engineering Applications

Rusu, Daniela; Ciolacu, Diana; Simionescu, Bogdan C.

doi:10.35812/cellulosechemtechnol.2019.53.88

Cited by 21 publications

(16 citation statements)

References 123 publications

(134 reference statements)

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“…Cellulose is the most known biodegradable polymer, being the main component of all vegetable fibers, with properties ranging from low cost and biocompatibility to high mechanical and thermal stability, which makes it a very promising and attractive polymer for various applications [ 54 , 55 , 56 , 57 ]. Its only drawback is its low solubility, which restricts its use especially in the biomedical and pharmaceutical fields, but this disadvantage can be overcome by obtaining cellulose derivatives by various chemical modification procedures, such as esterification, etherification, or oxidation [ 29 , 54 , 58 , 59 ].…”

Section: Cellulose-based Hydrogels In Drug Deliverymentioning

confidence: 99%

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Ciolacu¹,

Nicu²,

Ciolacu

2020

Materials

121

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Hydrogels, three-dimensional (3D) polymer networks, present unique properties, like biocompatibility, biodegradability, tunable mechanical properties, sensitivity to various stimuli, the capacity to encapsulate different therapeutic agents, and the ability of controlled release of the drugs. All these characteristics make hydrogels important candidates for diverse biomedical applications, one of them being drug delivery. The recent achievements of hydrogels as safe transport systems, with desired therapeutic effects and with minimum side effects, brought outstanding improvements in this area. Moreover, results from the utilization of hydrogels as target therapy strategies obtained in clinical trials are very encouraging for future applications. In this regard, the review summarizes the general concepts related to the types of hydrogel delivery systems, their properties, the main release mechanisms, and the administration pathways at different levels (oral, dermal, ocular, nasal, gastrointestinal tract, vaginal, and cancer therapy). After a general presentation, the review is focused on recent advances in the design, preparation and applications of innovative cellulose-based hydrogels in controlled drug delivery.

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Section: Cellulose-based Hydrogels In Drug Deliverymentioning

confidence: 99%

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Ciolacu¹,

Nicu²,

Ciolacu

2020

Materials

121

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“…Several techniques have been developed to shape cellulose-based materials into complex frameworks and support it with many materials to enhance their properties. The enhancement of the properties in the cellulose-based scaffold is majorly due to the desired demands for the growth, proliferation, differentiation, and shaping of cells in the environment in vivo conditions [195]. Furthermore, scaffolds must play a major role in the 3D shaping of the growing cells, forming natural tissue and then a whole organ.…”

Section: The New Role Of Cellulose-based Scaffolds Bioengineeringmentioning

confidence: 99%

A Review on Micro- to Nanocellulose Biopolymer Scaffold Forming for Tissue Engineering Applications

et al. 2020

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Biopolymers have been used as a replacement material for synthetic polymers in scaffold forming due to its biocompatibility and nontoxic properties. Production of scaffold for tissue repair is a major part of tissue engineering. Tissue engineering techniques for scaffold forming with cellulose-based material is at the forefront of present-day research. Micro- and nanocellulose-based materials are at the forefront of scientific development in the areas of biomedical engineering. Cellulose in scaffold forming has attracted a lot of attention because of its availability and toxicity properties. The discovery of nanocellulose has further improved the usability of cellulose as a reinforcement in biopolymers intended for scaffold fabrication. Its unique physical, chemical, mechanical, and biological properties offer some important advantages over synthetic polymer materials. This review presents a critical overview of micro- and nanoscale cellulose-based materials used for scaffold preparation. It also analyses the relationship between the method of fabrication and properties of the fabricated scaffold. The review concludes with future potential research on cellulose micro- and nano-based scaffolds. The review provides an up-to-date summary of the status and future prospective applications of micro- and nanocellulose-based scaffolds for tissue engineering.

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“…When they have particle sizes bigger than 100 m, they are usually called macrogels, while gels with particle sizes up to the micrometer range are called microgels. Finally, if these gels are smaller than 100 nm, they are usually considered nanogels [ 34 , 35 ].…”

Section: Advanced Functional Materials Based On Nanocellulose—general Characteristicsmentioning

confidence: 99%

Advanced Functional Materials Based on Nanocellulose for Pharmaceutical/Medical Applications

Nicu¹,

Ciolacu

Ciolacu³

2021

Pharmaceutics

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Nanocelluloses (NCs), with their remarkable characteristics, have proven to be one of the most promising “green” materials of our times and have received special attention from researchers in nanomaterials. A diversity of new functional materials with a wide range of biomedical applications has been designed based on the most desirable properties of NCs, such as biocompatibility, biodegradability, and their special physicochemical properties. In this context and under the pressure of rapid development of this field, it is imperative to synthesize the successes and the new requirements in a comprehensive review. The first part of this work provides a brief review of the characteristics of the NCs (cellulose nanocrystals—CNC, cellulose nanofibrils—CNF, and bacterial nanocellulose—BNC), as well as of the main functional materials based on NCs (hydrogels, nanogels, and nanocomposites). The second part presents an extensive review of research over the past five years on promising pharmaceutical and medical applications of nanocellulose-based materials, which have been discussed in three important areas: drug-delivery systems, materials for wound-healing applications, as well as tissue engineering. Finally, an in-depth assessment of the in vitro and in vivo cytotoxicity of NCs-based materials, as well as the challenges related to their biodegradability, is performed.

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Cellulose-Based Hydrogels in Tissue Engineering Applications

Cited by 21 publications

References 123 publications

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

A Review on Micro- to Nanocellulose Biopolymer Scaffold Forming for Tissue Engineering Applications

Advanced Functional Materials Based on Nanocellulose for Pharmaceutical/Medical Applications

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