Cellular uptake of solid lipid nanoparticles and cytotoxicity of encapsulated paclitaxel in A549 cancer cells

Tamoxifen-loaded solid lipid nanoparticles-induced apoptosis in breast cancer cell lines

“…In fact, it was reported that the IC 50 value of drug-loaded SLN composed of different materials was lower than that of free drug solution. [17] The IC 50 of SLN was time dependent and different between the two breast cancer cell lines tested. The IC 50 values suggest that SLN has low cytotoxicity to the MDA-MB231 and the MCF-7 cells.…”

Ceria Nanoparticles as Enzyme Mimetics

“…The utilization of nanoceria as oxidase under some special circumstances was also reported. Recently, nanoceria have been used for several applications either in biotic conditions or abiotic conditions, such as antioxidants, [63][64][65] capping [36] and neuroprotection agents, [66][67][68][69][70][71][72] biosensors, [23,28,73] immunoassays, [31,32,74] color indicator [27,[75][76][77][78][79] and so on.…”

“…Folate was used as the ligand for the folate receptor overexpressed in most cancer cells. [74] Nanoceria act as oxidase to oxidize the chromogenic substrate without any enzyme or hydrogen peroxide, providing a much faster and cheaper assay method. [31] Their later study showed that nanoceria conjugated with Protein G were able to immobilize antibodies, enabling the identification of cancer biomarkers at neutral pH conditions.…”

Bioavailability enhancers of herbal origin: An overview

“…Furthermore, the cellular cytotoxicities of paclitaxel were highly enhanced by the encapsulation of lipid matrix. The PEG and folate modified SLN could enhance the cellular uptake of SLN and the cellular cytotoxicity of drug by the membrane disturb ability of PEG chains on the SLN surface and the improved endocytosis mediated by folate receptor [108] .…”