Cellular transport and homeostasis of essential and nonessential metals

Martinez-Finley, Ebany J.; Chakraborty, Sudipta; Fretham, Stephanie J. B.; Aschner, Michael

doi:10.1039/c2mt00185c

Cited by 174 publications

(121 citation statements)

References 167 publications

(249 reference statements)

Supporting

Mentioning

120

Contrasting

Order By: Relevance

“…9,35,36 The effects were related to the states, valences and sizes of metals. For example, copper ions could react with specific odorants to enhance the responses of MOR244-3, 37 while copper nanoparticles could not improve the olfactory sensing.…”

Section: Discussionmentioning

confidence: 99%

Zinc Nanoparticles-equipped Bioelectronic Nose Using a Microelectrode Array for Odorant Detection

Zhang

et al. 2016

ANAL. SCI.

View full text Add to dashboard Cite

Bioelectronic noses, such as olfactory cell-and receptor-based biosensors, have important applications for biomimetic odorant detection in various fields. Here, a nanoparticle-equipped biosensor was designed to record extracellular potentials from olfactory receptor cells effectively. In this research, a microelectrode array (MEA) was combined with olfactory epitheliums as the olfactory biosensor to record electrophysiological signals of receptor cells in the epitheliums. Zinc nanoparticles (NanoZn) were employed along with the biosensor for different kinds of odorant measurements, which improved the electrophysiological responses to odor molecules. The NanoZn-equipped biosensor showed greater performance, such as a higher sensitivity and a larger signal-to-noise ratio, than that without the nanoparticles. Thus, this approach provided a promising method to improve the detecting performance of biosensors based on olfactory cells and receptors, which would bring broad application prospects for bioelectronic noses in environmental monitoring, food analysis, and healthcare diagnosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Zinc Nanoparticles-equipped Bioelectronic Nose Using a Microelectrode Array for Odorant Detection

Zhang

et al. 2016

ANAL. SCI.

View full text Add to dashboard Cite

show abstract

“…The Pb is harmful to most of the human body organs, and obstructs with metabolism and cellular activities (Martinez-Finley et al, 2012). A linear relationship is reported between blood Pb level and renal dysfunction in agerelated diseases.…”

Section: Toxic Metals and Healthmentioning

confidence: 99%

Role of heavy metals in human health and particularly in respect to diabetic patients

Asif¹

2017

TANG [HUMANITAS MEDICINE]

View full text Add to dashboard Cite

Minerals are individual of the components of foods and are not produced in the body but essential for best possible health. Several essential metals are vital for the appropriate performance of various enzymes, transcriptional factors and proteins that are essential in various biochemical paths. Metals like zinc (Zn), magnesium (Mg), and manganese (Mn) are cofactors of hundreds of enzymes. Zn is involved in the synthesis and secretion of insulin from the pancreatic β-cells. Chromium (Cr) increases the insulin receptors activity on target tissues, mainly in muscle cells. Insulin hormone is required to maintain the blood glucose amount in normal range. Continual increase of blood serum glucose level leads to marked chronic hyperglycemia or diabetes mellitus. Deficiency of insulin or its resistance, blood glucose level exceeds the upper limit of the common range of 126 mg/dl. Poor glucose control and diabetes changes the levels of essential trace elements such as Zn, Mg, Mn, Cr, iron etc. by rising urinary excretion and their related decrease in the blood. The aim of this article to discusses the important roles of essential trace elements in particular perspective of type 2 diabetes.

show abstract

Section: Discrimination Of Essential and Non-essential Elements Maskementioning

confidence: 99%

“…Specific transporters for non-essential metals such as CdPb are not known. These metals pass cell membranes via ZIP family (Zinc/iron permease), DMT1 (Divalent metal transporters), and P-type ATPase transport proteins, preventing essential elements from reaching their physiological optima [82]. Arsenite (AsO 3 3´) passes aquaglyceroporins with glycerol, urea, and water [82], whereas arsenate (AsO 4 3´) as phosphate (PO 4 3´) analog uses the phosphate transporters Pht1;1 and Pht1;4, e.g., in Arabidopsis thaliana [83].…”

Section: Discrimination Of Essential and Non-essential Elements Maskementioning

confidence: 99%

Stability of the Inherent Target Metallome in Seed Crops and a Mushroom Grown on Soils of Extreme Mineral Spans

Gramss

Voigt

2016

Agronomy

View full text Add to dashboard Cite

Extremes in soil mineral supply alter the metallome of seeds much less than that of their herbage. The underlying mechanisms of mineral homeostasis and the "puzzle of seed filling" are not yet understood. Field crops of wheat, rye, pea, and the mushroom Kuehneromyces mutabilis were established on a set of metalliferous uranium mine soils and alluvial sands. Mineral concentrations in mature plants were determined from roots to seeds (and to fungal basidiospores) by ICP-MS following microwave digestion. The results referred to the concentrations of soil minerals to illustrate regulatory breaks in their flow across the plant sections. Root mineral concentrations fell to a mean of 7.8% in the lower stem of wheat in proportions deviating from those in seeds. Following down-and up-regulations in the flow, the rachis/seed interface configured with cuts in the range of 1.6%-12% (AsPbUZn) and up-regulations in the range of 106%-728% (CuMgMnP) the final grain metallome. Those of pea seeds and basidiospores were controlled accordingly. Soil concentration spans of 9-109ˆin CuFeMnNiZn shrank thereby to 1.3-2ˆin seeds to reveal the plateau of the cultivar's desired target metallome. This was brought about by adaptations of the seed:soil transfer factors which increased proportionally in lower-concentrated soils. The plants thereby distinguished chemically similar elements (As/P; Cd/Zn) and incorporated even non-essential ones actively. It is presumed that high-and low-concentrated soils may impair the mineral concentrations of phloems as the donors of seed minerals. In an analytical and strategic top performance, essential and non-essential phloem constituents are identified and individually transferred to the propagules in precisely delimited quantities.

show abstract

Cellular transport and homeostasis of essential and nonessential metals

Cited by 174 publications

References 167 publications

Zinc Nanoparticles-equipped Bioelectronic Nose Using a Microelectrode Array for Odorant Detection

Zinc Nanoparticles-equipped Bioelectronic Nose Using a Microelectrode Array for Odorant Detection

Role of heavy metals in human health and particularly in respect to diabetic patients

Stability of the Inherent Target Metallome in Seed Crops and a Mushroom Grown on Soils of Extreme Mineral Spans

Contact Info

Product

Resources

About