Cellular toxicity of silicon carbide nanomaterials as a function of morphology

Chen, Fang; Li, Gongyi; Zhao, Eric; Li, Jingting; Hableel, Ghanim; Lemaster, Jeanne E.; Bai, Y.; Sen, George L.; Jokerst, Jesse V.

doi:10.1016/j.biomaterials.2018.06.027

Cited by 34 publications

(28 citation statements)

References 62 publications

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“…On the contrary, more studies suggest that 1D nanostructures have a certain level of impact on cellular behavior, including cell viability, elongation, and differentiation [93]. For instance, Chen et al reported a study on the toxicity of silicon carbide (SiC) nanowires, as shown in Figure 4B, and nanospheres on human mesenchymal stem cells (hMSCs) and cancer cells [94]. The impact of toxicity on metabolism, viability, proliferation, migration, oxidative stress, and differentiation potency were comprehensively examined.…”

Section: Recent Advances In Nanowire Biosensorsmentioning

confidence: 99%

Nanowire-Based Biosensors: From Growth to Applications

et al. 2018

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Over the past decade, synthesized nanomaterials, such as carbon nanotube, nanoparticle, quantum dot, and nanowire, have already made breakthroughs in various fields, including biomedical sensors. Enormous surface area-to-volume ratio of the nanomaterials increases sensitivity dramatically compared with macro-sized material. Herein we present a comprehensive review about the working principle and fabrication process of nanowire sensor. Moreover, its applications for the detection of biomarker, virus, and DNA, as well as for drug discovery, are reviewed. Recent advances including self-powering, reusability, sensitivity in high ionic strength solvent, and long-term stability are surveyed and highlighted as well. Nanowire is expected to lead significant improvement of biomedical sensor in the near future.

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Section: Recent Advances In Nanowire Biosensorsmentioning

confidence: 99%

Nanowire-Based Biosensors: From Growth to Applications

et al. 2018

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“…Botsoa et al showed there was no toxicity after the uptake of SiC nanoparticles by 3T3-L1 fibroblasts cells for one week [46]. However, the reported results are controversial because the cytotoxicity was also dose-dependent, morphology-dependent, and structure and surface property-dependent [47,48].The latest research demonstrated that SiC is a promising coating as dental material, which displayed adjustable color to match the dental shade guide used in clinic and wear resistance [49]. However, the oral environment could be a hostile to dental ceramic materials.…”

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confidence: 99%

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confidence: 99%

Novel Coating to Minimize Corrosion of Glass-Ceramics for Dental Applications

et al. 2020

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The effect of a novel silicon carbide (SiC) coating on the chemical durability of a fluorapatite glass-ceramic veneer was investigated by examining weight loss and ion release levels. The hypothesis that this novel coating will exhibit significant corrosion resistance was tested. Inductively coupled plasma atomic emission spectrometer (ICP) was used for ion concentration determination and scanning electron microscopy (SEM) for surface morphology analyses. Samples were immersed in pH 10 and pH 2 buffer solutions to represent extreme conditions in the oral cavity. Analyses were done at 15 and 30 days. The SiC coated group demonstrated significant reduction in weight loss across all solutions and time points (p < 0.0001). Ion release analyses demonstrated either a marginally lower or a significantly lower release of ions for the SiC-coated disks. SEM analysis reveals planarization of surfaces by the SiC-coated group. The surfaces of coated samples were not as corroded as the non-coated samples, which is indicative of the protective nature of these coatings. In conclusion, SiC is a novel coating that holds promise for improving the performance of ceramic materials used for dental applications.Materials 2020, 13, 1215 2 of 11 substances pH 8-14 (e.g., spinach, soybeans, and antacids) [1]. Eventually, this constant change in pH can decrease the fracture strength of glass-ceramics [13,14] and increase surface roughness [15,16]. This roughening of the restoration can lead to plaque accumulation and increased wear of the opposing enamel [17,18]. Dental restorations should be able to withstand these fluctuations in pH.Chemical durability of dental materials has been extensively studied because of the importance of this property on the longevity of the restoration. Intrinsic or extrinsic modifications can be used to improve chemical durability. Several studies have demonstrated chemical stability for glass-ceramics can be enhanced by (1) different ratio of compositions; (2) addition of oxides, such as CaO, K 2 O, and Al 2 O 3 ; and (3) fluorine and calcium phosphates as part of intrinsic modifications [19-23]. Extrinsic modification can be achieved by producing additional layers on the surface to enhance chemical durability and other physical properties [24-26]. Esquivel-Upshaw et al. showed that glazed material has better chemical resistance than non-glazed material [1]. Topateş et al. discussed the effect of different glaze compositions on chemical durability [25]. Rau et al. reported that the chemical resistance and corrosion rate of magnesium alloy were improved with the application of a glass-ceramic coating [26].Chemical durability is also important because leached ions during corrosion may not be safe. The literature demonstrated the cytotoxicity of materials in ceramic [27][28][29][30]. Elshahawy et al. reported that Zn had the highest cytotoxicity (60% cell viability) to fibroblast cells among the ions released from gold alloys and ceramic crowns in patients' saliva, followed by Cu > Ag > Pd > Al > Au > Si. The cyt...

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“…All samples were analyzed by flow cytometry (CytoFLEX S, Beckman Coulter, CA, USA). 26 This experimental protocol was verified by Southern Biotechnology Associates in the USA.…”

Section: Apoptosis Assaymentioning

confidence: 97%

“…Their livers were immediately excised and preserved at −80°C and would undergo messenger RNA (mRNA) analysis. 26…”

Section: Biointeraction Assay Using Flimmentioning

confidence: 99%

<p>Carbon Quantum Dots: In vitro and in vivo Studies on Biocompatibility and Biointeractions for Optical Imaging</p>

Tian¹,

Zeng²,

Liu³

et al. 2020

IJN

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Background: Understanding the biocompatibility and biointeractions of nano-carbon quantum dots (nano-CQDs) in vitro and in vivo is important for assessing their potential risk to human health. In the previous research, the physical properties of CQDs synthesized by the laser ablation in liquid (LAL) method were analyzed in detail; however, possible bioapplications were not considered. Materials and Methods: CQDs were prepared by LAL and characterized by atomic force microscopy, fluorescence lifetime, absorption spectrum, Fourier-transform infrared spectroscopy, and dynamic light scattering. Their biocompatibility was evaluated in vitro using assays for cytotoxicity, apoptosis, and biodistribution and in vivo using immunotoxicity and the relative expression of genes. Cells were measured in vitro using fluorescence-lifetime imaging microscopy to analyze the biointeractions between CQDs and intracellular proteins. Results: There were no significant differences in biocompatibility between the CQDs and the negative control. The intracellular interactions had no impact on the optical imaging of CQDs upon intake by cells. Optical imaging of zebrafish showed the green fluorescence was well dispersed. Conclusion: We have demonstrated that the CQDs have an excellent biocompatibility and can be used as efficient optical nanoprobes for cell tracking and biomedical labeling except for L929 and PC-3M cells.

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Cellular toxicity of silicon carbide nanomaterials as a function of morphology

Cited by 34 publications

References 62 publications

Nanowire-Based Biosensors: From Growth to Applications

Nanowire-Based Biosensors: From Growth to Applications

Novel Coating to Minimize Corrosion of Glass-Ceramics for Dental Applications

<p>Carbon Quantum Dots: In vitro and in vivo Studies on Biocompatibility and Biointeractions for Optical Imaging</p>

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