Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update

Mehta, Meenu; Dhanjal, Daljeet Singh; Paudel, Keshav Raj; Singh, Bhupender; Gupta, Gaurav; Rajeshkumar, S.; Thangavelu, Lakshmi; Tambuwala, Murtaza M.; Bakshi, Hamid A.; Chellappan, Dinesh Kumar; Pandey, Parijat; Dureja, Harish; Charbe, Nitin; Singh, Sachin Kumar; Shukla, Shakti D.; Nammi, Srinivas; Aljabali, Alaa A. A.; Wich, Peter; Hansbro, Philip M.; Satija, Saurabh; Dua, Kamal

doi:10.1007/s10787-020-00698-3

Cited by 284 publications

(27 citation statements)

References 235 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…cigarette smoke; CS) [16]. This leads to the activation of transforming growth factor-β (TGF-β) in the airway epithelium [16,17]. During this process, CS also interrupts the TGF-β signaling, which causes alveolar macrophages to release pro-inflammatory mediators, facilitating inflammation and fibrosis in the airway [16,18].…”

Section: Smoking and Non-communicable Airway Diseasementioning

confidence: 99%

Smoking and COVID-19: What we know so far

Shastri

Shukla

Chong

et al. 2021

Respiratory Medicine

Self Cite

104

View full text Add to dashboard Cite

Section: Smoking and Non-communicable Airway Diseasementioning

confidence: 99%

Smoking and COVID-19: What we know so far

Shastri

Shukla

Chong

et al. 2021

Respiratory Medicine

Self Cite

104

View full text Add to dashboard Cite

“…Naringenin has been reported to possess notable anti‐inflammatory (Luo et al., 2012), anticancer (Chang et al., 2017), immunomodulatory (Du et al., 2009), hepatoprotective (Hermenean et al., 2014), neuroprotective (Raza et al., 2013), and antidiabetic (Nguyen‐Ngo et al, 2019) activities. Earlier studies have documented that Naringenin prevents cell proliferation and motility by inhibiting the kinase, phosphoinositide‐3‐kinase (PI3K), in addition to the inhibition of the mitogen‐activated protein kinase (MAPK) pathways which eventually result in the inhibition of cell growth followed by cell death (Mehta et al., 2020; Yang et al., 2011). Furthermore, Naringenin also prevents lung cancer cell migration through the suppression of MMP‐9 (Chang et al., 2017).…”

Section: Introductionmentioning

confidence: 99%

Anti‐inflammatory and anticancer activities of Naringenin‐loaded liquid crystalline nanoparticles in vitro

et al. 2020

Self Cite

View full text Add to dashboard Cite

In this study, we had developed Naringenin-loaded liquid crystalline nanoparticles (LCNs) and investigated the anti-inflammatory and anticancer activities of Naringenin-LCNs against human airway epithelium-derived basal cells (BCi-NS1.1) and human lung epithelial carcinoma (A549) cell lines, respectively. The anti-inflammatory potential of Naringenin-LCNs evaluated by qPCR revealed a decreased expression of IL-6, IL-8, IL-1β, and TNF-α in lipopolysaccharide-induced BCi-NS1.1 cells. The activity of LCNs was comparable to the positive control drug Fluticasone propionate (10 nM). The anticancer activity was studied by evaluating the antiproliferative (MTT and trypan blue assays), antimigratory (scratch wound healing assay, modified Boyden chamber assay, and immunoblot), and anticolony formation activity in A549 cells. Naringenin LCNs showed promising antiproliferative, antimigratory, and anticolony formation activities in A549 cells, in vitro. Therefore, based on our observations and results, we conclude that Naringenin-LCNs may be employed as a potential therapy-based intervention to ameliorate airway inflammation and to inhibit the progression of lung cancer. Practical applications Naringenin was encapsulated into liquid crystalline nanoparticles, thus, attributing to their sustained-release nature. In addition, Naringenin-loaded LCNs efficiently reduced the levels of pro-inflammatory markers, namely, IL-1β, IL-6, TNF-α, and IL-8. In addition, the Naringenin-loaded LCNs also possess potent anticancer activity, when tested in the A549 cell line, as revealed by the inhibition of proliferation and migration of cells. They also attenuated colony formation and induced apoptosis in the A549 cells. The findings from our study could form the basis for future research that may be translated into an in vivo model to validate the possible therapeutic alternative for lung cancer using Naringenin-loaded LCNs. In addition, the applications of

show abstract

“…The elevated level of ROS plays a significant role in expanding tumor cells by altering the genes associated with apoptosis, cell proliferation and transcription factors [27]. Furthermore, ROS also downregulate the pro-apoptotic proteins by interfering with the Akt/PI3K and ERK cell signaling pathway, and upregulate the anti-apoptotic genes [28,29]. During the cancer progression stage, ROS interferes with cellular processes and upregulates the production of metalloproteinases by obstructing the angiogenesis process and, by anti-proteases, results in the metastasis of cancer cells [23,25,30].…”

Section: Cancermentioning

confidence: 99%

Antioxidant Functionalized Nanoparticles: A Combat against Oxidative Stress

et al. 2020

View full text Add to dashboard Cite

Numerous abiotic stresses trigger the overproduction of reactive oxygen species (ROS) that are highly toxic and reactive. These ROS are known to cause damage to carbohydrates, DNA, lipids and proteins, and build the oxidative stress and results in the induction of various diseases. To resolve this issue, antioxidants molecules have gained significant attention to scavenge these free radicals and ROS. However, poor absorption ability, difficulty in crossing the cell membranes and degradation of these antioxidants during delivery are the few challenges associated with both natural and synthetic antioxidants that limit their bioavailability. Moreover, the use of nanoparticles as an antioxidant is overlooked, and is limited to a few nanomaterials. To address these issues, antioxidant functionalized nanoparticles derived from various biological origin have emerged as an important alternative, because of properties like biocompatibility, high stability and targeted delivery. Algae, bacteria, fungi, lichens and plants are known as the producers of diverse secondary metabolites and phenolic compounds with extraordinary antioxidant properties. Hence, these compounds could be used in amalgamation with biogenic derived nanoparticles (NPs) for better antioxidant potential. This review intends to increase our knowledge about the antioxidant functionalized nanoparticles and the mechanism by which antioxidants empower nanoparticles to combat oxidative stress.

show abstract

Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update

Cited by 284 publications

References 235 publications

Smoking and COVID-19: What we know so far

Smoking and COVID-19: What we know so far

Anti‐inflammatory and anticancer activities of Naringenin‐loaded liquid crystalline nanoparticles in vitro

Antioxidant Functionalized Nanoparticles: A Combat against Oxidative Stress

Contact Info

Product

Resources

About