Cellular reactions and bone apposition to titanium surfaces with different surface roughness and oxide thickness cleaned by oxidation

Kanagaraja, Sanjiv; Wennerberg, Ann; Eriksson, Cecilia; Nygren, Håkan

doi:10.1016/s0142-9612(00)00362-8

Cited by 28 publications

(23 citation statements)

References 22 publications

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“…Then, the respiratory burst response of surface-adhering cells reflects a state of activity of the cells, and this is, in general terms, why the simple test may forecast the biocompatibility of materials. This assumption is in accord with the results of longterm studies of titanium implants in bone, showing that the bone contacting area of hydrophilic titanium 30 was considerably lower than typical values of hydrophobic titanium implants. 31 The effect of pores on the biocompatibility of materials seen in this study and reported earlier 7 can be explained along the same line of thought, by a drainage of inflammatory mediators from the surface.…”

Section: Discussionsupporting

confidence: 88%

Respiratory burst response of peritoneal leukocytes adhering to titanium and stainless steel

Nygren¹,

Hrustic²,

Karlsson³

et al. 2001

J. Biomed. Mater. Res.

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Titanium sheets, made hydrophilic by oxidative cleaning or hydrophobic by treatment with butanol, and stainless steel sheets with different patterns of pores (straight phi = 0.8 mm) were implanted into the peritoneal cavity of mice. The implants were removed after 2 h, and the surface-adhering leukocytes were stained with propidium iodide and fluorescein diacetate to quantitate cell adhesion and to indicate the presence of leaks in the cell membrane. The ability of the surface-adhering leukocytes to mount a respiratory burst response after stimulation with PMA or zymosan was measured by chemiluminiscence. The results show that stainless steel without pores induces membrane leakage in 80% of the surface-adhering leukocytes compared with 65% of cells adhering to porous steel. Hydrophilic titanium induces membrane leakage in 48% of the surface-adhering leukocytes compared with 19% of cells adhering to hydrophobic titanium. The respiratory burst response of the surface-adhering leukocytes stimulated with PMA was attenuated on stainless steel and hydrophilic titanium compared with hydrophobic titanium. Thus, butanol treatment of titanium and pores in stainless steel increase the biocompatibility of the materials.

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Section: Discussionsupporting

confidence: 88%

Respiratory burst response of peritoneal leukocytes adhering to titanium and stainless steel

Nygren¹,

Hrustic²,

Karlsson³

et al. 2001

J. Biomed. Mater. Res.

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show abstract

“…These findings were related to the composition of the adsorbed protein layers with higher amounts of fibronectin compared to albumin adsorbing to rough surfaces. Others however, present data showing no quantifiable change in cell number or activity, bone formation or removal torque (the force required to extract an implant, serving as a measure of biointegration) for in vivo examination of titanium implants having varying roughness [166]. As a result of this uncertainty it is not surprising that titanium implants currently in clinical use vary with respect to surface roughness.…”

Section: Topographymentioning

confidence: 99%

Surface strategies for control of neuronal cell adhesion: A review

Roach

Parker

Gadegaard

et al. 2010

Surface Science Reports

156

133

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“…Collectively with the physical and chemical aspects, surface roughness determines biological properties of materials. Numerous of works devoted to the roughness of medical devices report changes in adhesion and osteointegration process regarding to the different topography architecture [16][17][18][19][20][21][22][23][24][25]. The surface extension in nanoscale improves cell proliferation and osteoblast differentiation [26].…”

Section: Introductionmentioning

confidence: 99%

Laser and chemical surface modifications of titanium grade 2 for medical application

Kwaśniak

Pura

Zwolińska

et al. 2015

Applied Surface Science

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Cellular reactions and bone apposition to titanium surfaces with different surface roughness and oxide thickness cleaned by oxidation

Cited by 28 publications

References 22 publications

Respiratory burst response of peritoneal leukocytes adhering to titanium and stainless steel

Respiratory burst response of peritoneal leukocytes adhering to titanium and stainless steel

Surface strategies for control of neuronal cell adhesion: A review

Laser and chemical surface modifications of titanium grade 2 for medical application

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