Cellular Immunotherapy and the Lung

Daly, Sorcha; O’Sullivan, Andrew; MacLoughlin, Ronan

doi:10.3390/vaccines9091018

Cited by 6 publications

(2 citation statements)

References 146 publications

(173 reference statements)

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“…Further optimisation of lung dose may be possible through the use of more sophisticated devices such as those that make use of breath actuation or tailored/smaller droplet sizes [48][49][50][51]. This may be a critical consideration in the administration of novel, high-value therapeutics, such as advanced therapeutic medicinal products (ATMPs) or those with associated adverse side effects when suboptimal doses are delivered [52][53][54][55][56].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Aerosol Drug Delivery Options during Adult Mechanical Ventilation in the COVID-19 Era

et al. 2021

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Drug delivery devices used for aerosol therapy during mechanical ventilation to ease the symptoms of respiratory diseases provide beneficial treatment but can also pose challenges. Reflecting the significant changes in global guidance around aerosol usage and lung-protective ventilation strategies, seen in response to the COVID-19 pandemic, for the first time, we describe the drug delivery performance of commonly used devices under these conditions. Here, vibrating mesh nebuliser (VMN), jet nebuliser (JN) and pressurised metered-dose inhaler (pMDI) performance was assessed during simulated adult mechanical ventilation. Both standard test breathing patterns and those representatives of low tidal volume (LTV) ventilation with concurrent active and passive humidification were investigated. Drug delivery using a VMN was significantly greater than that with a JN and pMDI for both standard and LTV ventilation. Humidification type did not affect the delivered dose across all device types for standard ventilation. Significant variability in the pMDI dosing was evident, depending on the timing of actuation and the adapter type used. pMDI actuation synchronised with inspiration resulted in a higher delivered drug dose. The type of adapter used for pMDI actuation influenced drug delivery, with the highest dose observed using the CombiHaler.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Aerosol Drug Delivery Options during Adult Mechanical Ventilation in the COVID-19 Era

et al. 2021

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“…[1] As a result, TCs-related immunotherapy has shown the most potential. [2] While this immunotherapy is effective in DOI: 10.1002/adhm.202301536 the treatment of cancer, [3] autoimmune diseases, [4] and chronic inflammation, [5] the clinical effect is not always satisfactory. One important reason is the over-activation or insufficient activation of TCs due to the excessive or lack of mature DCs.…”

Section: Introductionmentioning

confidence: 99%

Glycopolymers With On/Off Anchors: Confinement Effect on Regulating Dendritic Cells

Heng,

Shan,

Yang

et al. 2023

Adv Healthcare Materials

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Insufficient activation or over‐activation of T cells due to the DCs state can cause negative effects on immunotherapy, making it crucial for DCs to maintain different states in different treatments. Polysaccharides is one of the most studied substances to promote DCs maturation. However, in many methods, optimizing the spatial dimension of the interaction between polysaccharides and cells has often been overlooked. Therefore, in this paper, we propose a new strategy from the perspective of spatial dimension to regulate the efficacy of polysaccharides in promoting DCs maturation. We introduce an anchoring molecule (DMA) to existing glycopolymers for the confinement effect, and the effect can be turned off by oxidation of DMA. Among the prepared On‐confined (PMD2), Off‐confined (PMD2‐O), and Norm (PM2) glycopolymers, PMD2 and PMD2‐O show the best and worst results, respectively, in terms of the amount of binding to DCs and the effect on promoting DCs maturation. This sufficiently shows that the turn‐on and off of confinement effect can regulate the maturation of DCs by polysaccharides. Based on the all‐atom molecular dynamics (MD) simulation, the mechanism of difference in the confinement effect was explained. This simple method can also be used to regulate other molecule‐cell interactions to guide cell behavior.This article is protected by copyright. All rights reserved

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Viral Nanoparticles‐Mediated Delivery of Therapeutic Cargo

Zanganeh

Doroudian

Nowzari

et al. 2023

Advanced Therapeutics

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The rapid advancement of nanotechnology in recent years has opened new avenues of investigation for biomedical sciences. Viral nanoparticles (VNPs) are formulated from plant viruses, mammalian viruses, or bacteriophages. Based on their structure, viruses, and synthetic carriers have been utilized to design bio‐inspired nanocarriers, which serve as building blocks for innovative therapeutic applications. Scientists can chemically or genetically engineer VNPs to encompass various properties, such as enhancing their functionalization with therapeutic molecules and imaging reagents, enabling targeted delivery to specific ligands. The implementation of these novel nanocarrier platforms can revolutionize treatments for cancer, infectious diseases, and chronic illnesses. The primary goal of drug delivery systems is to localize cargo to the specific target site, increasing therapeutic benefits and minimizing off‐target effects. This review critically evaluates the major virus species used as nanocarriers, their applications in therapeutics, and their advantages and disadvantages.

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Cellular Immunotherapy and the Lung

Cited by 6 publications

References 146 publications

Evaluation of Aerosol Drug Delivery Options during Adult Mechanical Ventilation in the COVID-19 Era

Evaluation of Aerosol Drug Delivery Options during Adult Mechanical Ventilation in the COVID-19 Era

Glycopolymers With On/Off Anchors: Confinement Effect on Regulating Dendritic Cells

Viral Nanoparticles‐Mediated Delivery of Therapeutic Cargo

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