Cellular distributions and functions of histamine, octopamine, and serotonin in the peripheral visual system, brain, and circumesophageal ring of the horseshoe crabLimulus polyphemus

Battelle, Barbara‐Anne; Calman, Bruce G.; Hart, Mary K.

doi:10.1002/(sici)1097-0029(19990115/01)44:2/3<70::aid-jemt2>3.0.co;2-v

Cited by 34 publications

(29 citation statements)

References 38 publications

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“…Histamine is the neurotransmitter of Drosophila photoreceptors, and genetic evidence indicates that a mechanism to accumulate histamine into photoreceptors exists in Drosophila (Melzig et al, 1998), as it does in other species (Battelle et al, 1999;Stuart et al, 2002;Stuart et al, 1996). Flies lacking the enzyme that synthesizes histamine, histidine decarboxylase (HDC), are blind and have lost histamine immunolabelling in the optic lobe.…”

Section: Monoamine Neurotransmitter Transporters Not Found In Ourmentioning

confidence: 99%

Comparative sequence analysis and tissue localization of members of the SLC6 family of transporters in adultDrosophila melanogaster

Thimgan

Berg

Stuart

2006

Journal of Experimental Biology

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SUMMARY The SLC6 family comprises proteins that move extracellular neurotransmitters, amino acids and osmolytes across the plasma membrane into the cytosol. In mammals, deletion of SLC6 family members has dramatic physiologic consequences, but in the model organism Drosophila melanogaster, little is known about this family of proteins. Therefore,in this study we carried out an initial analysis of 21 known or putative SLC6 family members from the Drosophila genome. Protein sequences from these genes segregated into either well-defined subfamilies, including the novel insect amino acid transporter subfamily, or into a group of weakly related sequences not affiliated with a recognized subfamily. Reverse transcription-polymerase chain reaction analysis and in situhybridization showed that seven of these genes are expressed in the CNS. In situ hybridization revealed that two previously cloned SLC6 members, the serotonin and dopamine transporters, were localized to presumptive presynaptic neurons that previously immunolabelled for these transmitters. RNA for CG1732 (the putative GABA transporter) and CG15088 (a member of the novel insect amino acid transporter family)was localized in cells likely to be subtypes of glia, while RNA for CG5226, CG10804 (both members of the orphan neurotransmitter transporter subfamily) and CG5549 (a putative glycine transporter)were expressed broadly throughout the cellular cortex of the CNS. Eight of the 21 sequences were localized outside the CNS in the alimentary canal,Malpighian tubules and reproductive organs. Localization for six sequences was not found or not attempted in the adult fly. We used the Drosophilaortholog of the mammalian vesicular monoamine transporter 2, CG33528,to independently identify monoaminergic neurons in the adult fly. RNA for CG33528 was detected in a limited number of cells in the central brain and in a beaded stripe at the base of the photoreceptors in the position of glia, but not in the photoreceptors themselves. The SLC6 localization observations in conjunction with likely substrates based on phylogenetic inferences are a first step in defining the role of Na/Cl-dependent transporters in Drosophila physiology.

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Section: Monoamine Neurotransmitter Transporters Not Found In Ourmentioning

confidence: 99%

Comparative sequence analysis and tissue localization of members of the SLC6 family of transporters in adultDrosophila melanogaster

Thimgan

Berg

Stuart

2006

Journal of Experimental Biology

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“…Aspects that have been explored in the past include adult ommatidial morphology of the lateral eyes (review Fahrenbach, 1975), organization of the retinal projections into the brain as well as efferent projections Barlow, 1980, 1982;Batra and Chamberlain, 1985;, and distribution of the visual pathway neurotransmitters (reviewed in Battelle et al, 1999) octopamine (Evans et al, 1983), serotonin , FMRFamide and substance P (Chamberlain and Engbretson, 1982;Lewandoswski et al, 1989), histamine , and acetylcholine (Hornstein et al, 1994). Additionally, circadian modulation of the photoresponse (e.g., Battelle et al, 1998Battelle et al, , 2000Battelle et al, , 2001Sacunas et al, 2002;Waren and Chamberlain, 2002;Ankrom and Chamberlain, 2002;Dalal et al, 2003;Pieprzyk et al, 2003;Runyon et al, 2004;reviews, Barlow, 2001;Battelle, 2002), and both computational and behavioral aspects of vision (reviewed in Barlow et al, 2001) are active areas of current research.…”

Section: Introductionmentioning

confidence: 99%

Evolution of arthropod visual systems: Development of the eyes and central visual pathways in the horseshoe crabLimulus polyphemusLinnaeus, 1758 (Chelicerata, Xiphosura)

Harzsch

Vilpoux

Blackburn

et al. 2006

Developmental Dynamics

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Despite ongoing interest into the architecture, biochemistry, and physiology of the visual systems of the xiphosuran Limulus polyphemus, their ontogenetic aspects have received little attention. Thus, we explored the development of the lateral eyes and associated neuropils in late embryos and larvae of these animals. The first external evidence of the lateral eyes was the appearance of white pigment spots-guanophores associated with the rudimentary photoreceptors-on the dorsolateral side of the late embryos, suggesting that these embryos can perceive light. The first brown pigment emerges in the eyes during the last (third) embryonic molt to the trilobite stage. However, ommatidia develop from this field of pigment toward the end of the larval trilobite stage so that the young larvae at hatching do not have object recognition. Double staining with the proliferation marker bromodeoxyuridine (BrdU) and an antibody against L. polyphemus myosin III, which is concentrated in photoreceptors of this species, confirmed previous reports that, in the trilobite larvae, new cellular material is added to the eye field from an anteriorly located proliferation zone. Pulse-chase experiments indicated that these new cells differentiate into new ommatidia. Examining larval eyes labeled for opsin showed that the new ommatidia become organized into irregular rows that give the eye field a triangular appearance. Within the eye field, the ommatidia are arranged in an imperfect hexagonal array. Myosin III immunoreactivity in trilobite larvae also revealed the architecture of the central visual pathways associated with the median eye complex and the lateral eyes. Double labeling with myosin III and BrdU showed that neurogenesis persists in the larval brain and suggested that new neurons of both the lamina and the medulla originate from a single common proliferation zone. These data are compared with eye development in Drosophila melanogaster and are discussed with regard to new ideas on eye evolution in the Euarthropoda. Developmental Dynamics 235:2641-2655, 2006.

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“…stance immunohistochemically detected in the nervous system of crustaceans (Beltz and Kravitz, 1983) and it has been mapped in numerous arthropod species, both in adult and in larval specimens (Battelle et al, 1999;Harzsch and Waloszek, 2000). It is believed that in decapods, serotonin may act in both the central and peripheral nervous systems, controlling the threat postures and escape mechanisms that characterize agonistic encounters (Harris-Warrick and Kravitz 1984;Yeh et al, 1997), as well the rate of heart beat (Listerman et al, 2000).…”

mentioning

confidence: 99%

Presence and distribution of serotonin immunoreactivity in the cyprids of the barnacle Balanus amphitrite

Gallus¹,

Ramoino²,

Faimali³

et al. 2009

Eur J Histochem

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Cellular distributions and functions of histamine, octopamine, and serotonin in the peripheral visual system, brain, and circumesophageal ring of the horseshoe crabLimulus polyphemus

Cited by 34 publications

References 38 publications

Comparative sequence analysis and tissue localization of members of the SLC6 family of transporters in adultDrosophila melanogaster

Comparative sequence analysis and tissue localization of members of the SLC6 family of transporters in adultDrosophila melanogaster

Evolution of arthropod visual systems: Development of the eyes and central visual pathways in the horseshoe crabLimulus polyphemusLinnaeus, 1758 (Chelicerata, Xiphosura)

Presence and distribution of serotonin immunoreactivity in the cyprids of the barnacle Balanus amphitrite

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