Cellular Congenital Mesoblastic Nephroma in a Newborn

Tripathy, Prasanta Kumar; Behera, Suresh Kumar; Mohanty, Hiranya Kishor

doi:10.21699/jns.v6i2.564

Cited by 5 publications

(10 citation statements)

References 3 publications

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“…Chances of misdiagnosis should be remembered due to resemblance with more common renal tumors and lack of familiarity with this rare neonatal tumor. So, authors believe that this is an underreported pediatric renal neoplasm [18]. In spite of the benign nature, CMN can metastasize and there are chances of recurrence in 5-10% cases [20].…”

Section: Discussionmentioning

confidence: 93%

“…Congenital mesoblastic nephroma is a rare stromal neoplasm, usually presenting as asymptomatic abdominal mass [18]. It typically affects young infants and is reported as commonest kidney tumor in children below 3 months of age [4,19].…”

Section: Discussionmentioning

confidence: 99%

“…It typically affects young infants and is reported as commonest kidney tumor in children below 3 months of age [4,19]. Two histological types of CMN are recognized, (i) classical type (24%) representing purely benign, (ii) cellular type (66%) having aggressive pathological behaviour [18,20]. A mixed variant containing features of both the types is also encountered in 10% cases [19].…”

Section: Discussionmentioning

confidence: 99%

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Solid tumors in neonates: demographic pattern and management in a tertiary care centre

et al. 2019

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Background: Neonatal solid tumors are different in their clinical and biological behavior from older children. Rarity of these tumors, histological diversity and paucity of information leads to difficulty in diagnosis and management. The objective of the study is to analyse the demographic pattern, clinico-pathological features and management of neonatal solid tumors along with comparing the outcome with similar available studies. Methods: The retrospective study was carried out in a tertiary care pediatric institute between April 2014 and March 2019. The medical records of neonates admitted and operated for solid tumors were analysed. The incidence, clinical presentation, pathological findings, management and outcome were studied. Results: Out of 85 children operated for solid tumors, 24 cases were presented and operated in neonatal period. Sacrococcygeal teratoma (17 cases) was the most common neoplasm followed by retroperitoneal teratoma (3 cases). The male to female ratio in sacrococcygeal teratoma was almost equal in the present study. Two neonates with congenital mesoblastic nephroma and a 5-day girl with biphasic pulmonary blastoma were remarkable findings in this study. There was no mortality or tumor recurrence during postoperative period and follow up. Conclusions: Neonatal tumors are rare neoplasms and are different in their clinical and biological behavior from older children. The rarity, histological diversity and paucity of information leads to difficulty in diagnosis and management. Benign tumors may have aggressive appearance, but prognosis is good after complete surgical excision. Multidisciplinary methodological management approach is essential for optimal survival of these tiny neonates.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Solid tumors in neonates: demographic pattern and management in a tertiary care centre

et al. 2019

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“…Congenital mesoblastic nephroma (CMN) is generally considered a benign tumor. [1] Nephrectomy is usually curative and adjuvant treatment is not necessary. [1] However, more aggressive clinical behavior in the form of recurrence and metastasis has also been observed.…”

Section: Introductionmentioning

confidence: 99%

“…[1] Nephrectomy is usually curative and adjuvant treatment is not necessary. [1] However, more aggressive clinical behavior in the form of recurrence and metastasis has also been observed. [2,3] Herein, we report a case of recurrent congenital mesoblastic nephroma treated with surgery alone.…”

Section: Introductionmentioning

confidence: 99%

Congenital Mesoblastic Nephroma in a Premature Neonate: Should We Give Adjuvant Chemotherapy?

Kechiche¹,

Makhlouf²,

Belhassen³

et al. 2019

J Neonatal Surg

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Congenital mesoblastic nephroma (CMN) is a rare renal tumor of infancy. Complete surgical excision is often sufficient. A premature neonate underwent left radical nephrectomy for CMN without any adjuvant therapy. Pathology was consistent with cellular type CMN. Six months postoperatively, the patient developed recurrence. He subsequently underwent re-excision without any adjuvant chemotherapy. The baby is tumor free for more than a year.

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Fetal Congenital Mesoblastic Nephroma: Case Report

Patil

Vemarapu

2021

Journal of Fetal Medicine

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Congenital mesoblastic nephroma (CMN) is a rare renal tumor, but the commonest tumor of early infancy. It can be detected prenatally as a renal mass and is associated with prematurity, polyhydramnios, and neonatal hypertension. We report a case of congenital mesoblastic nephroma which presented as a large unilateral solid renal mass detected at 33 weeks of gestation associated with oligohydramnios and small for gestational age (SGA) fetus. Ultrasound features were a large hypoechoic mass arising from the upper pole of the Left kidney measuring 52 9 43 9 32 mm. Inside the mass there were incomplete septae and a few cystic areas, likely hemorrhagic areas, with minimal peripheral vascularity. The mass was surrounded by a hyperechoic capsule. The left adrenal gland could be imaged separately. The baby was delivered by a lower segment cesarean section (LSCS) at 38 weeks of gestation. After birth, the baby presented with a mass per abdomen with no other symptoms and no hypertension. CT scan and ultrasound guided biopsy confirmed the finding of the cellular variant of congenital mesoblastic nephroma. Left radical nephrectomy with adrenal gland conservation was performed on day 8 of life. Postoperative adjuvant chemotherapy was administered. On follow-up, the baby is asymptomatic with no relapse or metastasis. Fetal CMN and Wilms tumor have overlapping ultrasound features and are difficult to differentiate on prenatal ultrasound. Prenatal detection of fetal renal tumors and timely neonatal management improve perinatal outcome.

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Cellular Congenital Mesoblastic Nephroma in a Newborn

Abstract: Please see fulltext.

Cited by 5 publications

References 3 publications

Solid tumors in neonates: demographic pattern and management in a tertiary care centre

Solid tumors in neonates: demographic pattern and management in a tertiary care centre

Congenital Mesoblastic Nephroma in a Premature Neonate: Should We Give Adjuvant Chemotherapy?

Fetal Congenital Mesoblastic Nephroma: Case Report

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