Cellular and Molecular Toxicology of Nanoparticles

Zielińska, Anna; Santos, David S. dos; Campos, J.; Santini, A.; Severino, Patrícia; Shimojo, Andréa Arruda Martins; Souto, Selma B.; Souto, Eliana B.

doi:10.1201/9781003045151-11

Cited by 3 publications

(3 citation statements)

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“…Moreover, AgNO 3 was used as a source of Ag + for comparison. Spherical AgNPs coated with the investigated coating materials have been widely used for several applications [ 13 , 23 , 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

Silver Nanoparticles Impair Cognitive Functions and Modify the Hippocampal Level of Neurotransmitters in a Coating-Dependent Manner

Dziendzikowska

Wesierska

Gromadzka-Ostrowska

et al. 2021

IJMS

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Due to their potent antibacterial properties, silver nanoparticles (AgNPs) are widely used in industry and medicine. However, they can cross the brain–blood barrier, posing a risk to the brain and its functions. In our previous study, we demonstrated that oral administration of bovine serum albumin (BSA)-coated AgNPs caused an impairment in spatial memory in a dose-independent manner. In this study, we evaluated the effects of AgNPs coating material on cognition, spatial memory functioning, and neurotransmitter levels in rat hippocampus. AgNPs coated with BSA (AgNPs(BSA)), polyethylene glycol (AgNPs(PEG)), or citrate (AgNPs(Cit)) or silver ions (Ag+) were orally administered at a dose of 0.5 mg/kg b.w. to male Wistar rats for a period of 28 days, while the control (Ctrl) rats received 0.2 mL of water. The acquisition and maintenance of spatial memory related to place avoidance were assessed using the active allothetic place avoidance task, in which rats from AgNPs(BSA), AgNPs(PEG), and Ag+ groups performed worse than the Ctrl rats. In the retrieval test assessing long-term memory, only rats from AgNPs(Cit) and Ctrl groups showed memory maintenance. The analysis of neurotransmitter levels indicated that the ratio between serotonin and dopamine concentration was disturbed in the AgNPs(BSA) rats. Furthermore, treatment with AgNPs or Ag+ resulted in the induction of peripheral inflammation, which was reflected by the alterations in the levels of serum inflammatory mediators. In conclusion, depending on the coating material used for their stabilization, AgNPs induced changes in memory functioning and concentration of neurotransmitters.

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Section: Discussionmentioning

confidence: 99%

Silver Nanoparticles Impair Cognitive Functions and Modify the Hippocampal Level of Neurotransmitters in a Coating-Dependent Manner

Dziendzikowska

Wesierska

Gromadzka-Ostrowska

et al. 2021

IJMS

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“…The acidic environment of the lysosome leads to the burst discharge of NMs that interact with the proteins of cytosol and other molecules producing ROS, which mediate oxidative stress into the mitochondria, so cytochrome c is discharged. Discharged cytochrome c connects to Apaf-1, which stimulates the caspase cascade reaching to caspase-dependent apoptosis, leading to cell death and DNA fragmentation (Zielińska et al, 2020 ) …”

Section: Toxic Effects Of Nanomaterials On Healthmentioning

confidence: 99%

“…NMs could provoke cytotoxicity (necrosis, apoptosis), genotoxicity (DNA destruction), the activation of endothelial (adhesion molecules, the adhesion of monocyte), and NOS dysfunction (over-production of ROS) in endothelial cells. LDH Lactate dehydrogenase, NOS Endothelial nitric oxide synthase (Zielińska et al, 2020 ) …”

Section: Toxic Effects Of Nanomaterials On Healthmentioning

confidence: 99%

Nanomaterial-Augmented Formulation of Disinfectants and Antiseptics in Controlling SARS CoV-2

Jamshidinia

Mohammadipanah

2022

Food Environ Virol

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The worldwide COVID-19 pandemic has brought significant consideration toward innovative strategies for overcoming the viral spread. Nanotechnology will change our lives in several forms as its uses span from electronics to pharmaceutical procedures. The use of nanoparticles provides a possibility to promote new antiviral treatments with a low possibility of increasing drug resistance compared to typical chemical-based antiviral treatments. Since the long-term usage of disinfectants and antiseptics at high concentrations has deleterious impacts on well-being and the environment, this review was intended to discuss the antiviral activity of disinfectants and antiseptics required for their activity against respiratory viruses especially SARS-CoV-2. It could improve the inhibition of viral penetration into cells, solvation of the lipid bilayer envelope, and ROS production, therefore enhancing the effect of disinfectants. However, significant concerns about nanomaterial's hazardous effects on individuals and the environment are increasing as nanotechnology flourishes. In this review, we first discuss the significant and essential types of nanomaterials, especially silver and copper, that could be used as antiviral agents and their viral entry mechanisms into host cells. Further, we consider the toxicity on health, and environmental concerns of nanoparticles. Eventually, we present our outlook on the fate of nanomaterials toward viral diseases.

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Recent Advances of Nanotechnology in Mitigating Emerging Pollutants in Water and Wastewater: Status, Challenges, and Opportunities

Naskar

Boatemaa

Rumjit

et al. 2022

Water Air Soil Pollut

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Cellular and Molecular Toxicology of Nanoparticles

Cited by 3 publications

References 1 publication

Silver Nanoparticles Impair Cognitive Functions and Modify the Hippocampal Level of Neurotransmitters in a Coating-Dependent Manner

Silver Nanoparticles Impair Cognitive Functions and Modify the Hippocampal Level of Neurotransmitters in a Coating-Dependent Manner

Nanomaterial-Augmented Formulation of Disinfectants and Antiseptics in Controlling SARS CoV-2

Recent Advances of Nanotechnology in Mitigating Emerging Pollutants in Water and Wastewater: Status, Challenges, and Opportunities

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