Cell surface-based sensing with metallic nanoparticles

Jiang, Ziwen; Le, Ngoc D. B.; Gupta, Akash; Rotello, Vincent M.

doi:10.1039/c4cs00387j

Cited by 82 publications

(57 citation statements)

References 51 publications

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“…7,8 For example, the well-defined surface plasmon resonance (SPR) of these particles has been employed for sensing, where a variety of sensors have been developed by following changes of the SPR during the sensing event. 9,10,11 By the use of this colorimetric strategy, not only the detection of small molecules and ions is possible, but also more complex systems such as proteins, cells, and by extension diseases can be detected. 12,13,14,15 …”

Section: Introductionmentioning

confidence: 99%

Ultrastable and Biofunctionalizable Gold Nanoparticles

Gupta

Moyano

Parnsubsakul

et al. 2016

ACS Appl. Mater. Interfaces

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135

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Gold nanoparticles provide an excellent platform for biological and material applications due to their unique physical and chemical properties. However, decreased colloidal stability and formation of irreversible aggregates while freeze-drying nanomaterials, limits their use in real world applications. Here, we report a new generation of surface ligands based on a combination of short oligo (ethylene glycol) chain and zwitterions capable of providing non-fouling characteristics, while maintaining colloidal stability and functionalization capabilities. Additionally, conjugation of these gold nanoparticles with avidin can help developing a universal toolkit for further functionalization of nanomaterials.

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Section: Introductionmentioning

confidence: 99%

Ultrastable and Biofunctionalizable Gold Nanoparticles

Gupta

Moyano

Parnsubsakul

et al. 2016

ACS Appl. Mater. Interfaces

Self Cite

135

104

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“…antibody, aptamer, and phage), electrostatic interaction-based recognition processes provide an alternative sensing strategy for bacterial cells, relying on non-specific recognition. 40 These electrostatic interaction-based approaches are versatile, and can provide a sensing platform to either detect a wide range of bacterial strains, or recognize individual bacterial cell strains.…”

Section: Electrostatic Interaction-based Sensing Of Bacteriamentioning

confidence: 99%

“…The patterns formed by differential interactions between nanoprobes and bacterial cells can serve as fingerprints to identify and analyze the bacterial cells. 40 As shown in Fig. 12a, nanoprobes A-G were interacted with bacteria 1–4, resulting in multiple responses to form array-based patterns.…”

Section: Electrostatic Interaction-based Sensing Of Bacteriamentioning

confidence: 99%

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Integrating recognition elements with nanomaterials for bacteria sensing

et al. 2017

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“…Among the inorganic NPs, only biocompatible magnetite composite formulations are approved by the FDA; however, inorganic NPs have other outstanding applications in sensing, imaging and thermal cancer therapy, in addition to the capability of drug delivery (Table ) …”

Section: Selection Of Nanoparticle Typementioning

confidence: 99%

Exploring Factors for the Design of Nanoparticles as Drug Delivery Vectors

et al. 2018

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To achieve optimal results when employing nanoparticles in biomedical fields, choosing the right type of nanoparticle and determining the correct procedure for drug loading are key factors. Each type of nanoparticle presents a determined set of characteristics that are, in some cases, unique. In general, their surface charge, geometry or hydrophilic character may be limiting factors, depending on what their intended application is. Once synthesized, additional factors, such as their interaction with biological systems and liberation mechanisms into the target cells, also need to be taken into account. Multiple advantages arise from the use of nanoparticles, such as the capability to solubilize hydrophobic compounds and an increased bioavailability. Those advantages justify the extensive and delicate study that should be undertaken in order to use them as drug delivery agents. One of the most important factors for the design of a drug delivery system with nanoparticles is achieving a high drug-to-nanoparticle ratio. In this Minireview, all of these key factors, both physicochemical and biological, are described, and special emphasis is placed on loading methods employed to introduce drugs into nanoparticles.

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Cell surface-based sensing with metallic nanoparticles

Cited by 82 publications

References 51 publications

Ultrastable and Biofunctionalizable Gold Nanoparticles

Ultrastable and Biofunctionalizable Gold Nanoparticles

Integrating recognition elements with nanomaterials for bacteria sensing

Exploring Factors for the Design of Nanoparticles as Drug Delivery Vectors

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