2018
DOI: 10.1002/cphc.201800388
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Exploring Factors for the Design of Nanoparticles as Drug Delivery Vectors

Abstract: To achieve optimal results when employing nanoparticles in biomedical fields, choosing the right type of nanoparticle and determining the correct procedure for drug loading are key factors. Each type of nanoparticle presents a determined set of characteristics that are, in some cases, unique. In general, their surface charge, geometry or hydrophilic character may be limiting factors, depending on what their intended application is. Once synthesized, additional factors, such as their interaction with biological… Show more

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Cited by 14 publications
(7 citation statements)
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References 250 publications
(364 reference statements)
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“…This is an unexpected and very interesting new aspect of DNA binding since such an effect is more commonly associated with polycations. Given that cationic nanoparticles can disrupt membranes in the cell, 33,34 anionic nanoparticles that can cause such dramatic effects on DNA may have fascinating potential for new approaches to in-cell nucleic acid recognition.…”
Section: Discussionmentioning
confidence: 99%
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“…This is an unexpected and very interesting new aspect of DNA binding since such an effect is more commonly associated with polycations. Given that cationic nanoparticles can disrupt membranes in the cell, 33,34 anionic nanoparticles that can cause such dramatic effects on DNA may have fascinating potential for new approaches to in-cell nucleic acid recognition.…”
Section: Discussionmentioning
confidence: 99%
“…Nevertheless, in intriguing early studies, Murphy 56 andÅkerman 57 reported some form of interaction between ds-DNA and citrate coated gold nanoparticles and there have been some subsequent similar reports. 33,58,[73][74][75] The interaction is weak and its nature unclear, with suggestions including direct adsorption to the gold with displacement of the citrate. 56 This does demonstrate that anionic charge on the surface of the nanoparticle does not exclude DNA-binding as long as there are sufficient favourable interactions to counter it; on a macromolecule such as a nanoparticle this may be possible.…”
Section: Interaction Of Gnp-lip-based Nanocarriers With Ct-dnamentioning
confidence: 99%
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“…The selected PEO‐ b ‐PGEA block copolymers were tested to produce the boron‐rich nanoparticles (BNs) via simple co‐assembly of guanidinium moieties with [B 12 H 12 ] 2− as the first example of polymeric nanostructures based on [B 12 H 12 ] 2− ion pairing. Thus, no exoskeletal substitution of borane cluster was needed [35–37] . Furthermore, considering the important roles of size and charge for the cellular uptake of nanocarriers, [38] all the BNs were designed with the size range 10–20 nm, and kept charge neutral (compensation of guanidinium and [B 12 H 12 ] 2− charges).…”
Section: Methodsmentioning
confidence: 99%
“…Thus, no exoskeletal substitution of borane clusterw as needed. [35][36][37] Furthermore, considering the important roles of size and charge for the cellular uptake of nanocarriers, [38] all the BNs were designed with the size range 10-20 nm, and kept charge neutral (compensation of guanidinium and [B 12 H 12 ] 2À charges). Based on the benefit of previousr esearch,B Ns were expected to exhibit high biocompatibility,l ong retention time in plasma, and good cellular uptake.…”
mentioning
confidence: 99%