Integrating recognition elements with nanomaterials for bacteria sensing

Chen, Juhong; Andler, Stephanie M.; Goddard, Julie M.; Nugen, Sam R.; Rotello, Vincent M.

doi:10.1039/c6cs00313c

Cited by 289 publications

(171 citation statements)

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“…Detection techniques to assess and reduce the bacterial risk to public health in food, medical situations, and the environment have long been studied . Traditional methods, such as the minimum inhibitory concentration (MIC) and polymerase chain reaction, have been used to detect and identify drug‐resistant bacteria based on their phenotypes and genotypes, respectively . Although these methods are effective, they require bacterial proliferation, which is laborious and time‐consuming.…”

Section: Methodsmentioning

confidence: 99%

Chiral Upconversion Heterodimers for Quantitative Analysis and Bioimaging of Antibiotic‐Resistant Bacteria In Vivo

Sun

Hao

et al. 2018

Advanced Materials

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Heterodimers of upconversion nanoparticles (UCNPs) and gold yolk–shell nanoparticles are fabricated for the quantification of polymyxin‐B‐resistant Escherichia coli. They produce two signals, circular dichroism (CD) and upconversion luminescence (UCL). Interestingly, due to the different affinity of polymyxin B for sensitive and resistant strain, as the concentration of polymyxin B increases, the amount of UCNPs in sensitive bacteria increases sharply, increasing the intracellular UCL signal at a low polymyxin B concentration immobilized on the UCNP. The CD intensity is correspondingly reduced as the amount of UCNPs in solution decreased. Meanwhile, for polymyxin‐B‐resistant strain, the intracellular UCL increases slowly even in a high polymyxin B concentration, and the CD intensity in solution is also enhanced because of the inefficient entering of UCNP. Therefore, based on the concentration of polymyxin B coupled to the UCNPs, the levels of polymyxin‐B‐resistant bacteria can be detected with dual signals. Importantly, with 980 nm irradiation, both polymyxin‐B‐sensitive strains and polymyxin‐resistant bacteria used to induce infection in mice are detected with UCL imaging in vivo and treated well with photodynamic therapy. This novel dual‐mode heterodimer has potential utility for the advanced surveillance and control of drug‐resistant bacteria.

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Section: Methodsmentioning

confidence: 99%

Chiral Upconversion Heterodimers for Quantitative Analysis and Bioimaging of Antibiotic‐Resistant Bacteria In Vivo

Sun

Hao

et al. 2018

Advanced Materials

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“…[22] In addition to the high photothermal conversion efficiency, [17][18][19][20][21] light-induced copper ion release from Cu 2−x S NCs can initiate generation of hydroxyl radicals for efficient killing of cells. [23] Current targeting strategies involve the use of antibodies, [24] aptamers, [25] or small molecules such as vancomycin. [11] One of the inherent problems with phototherapy is the nonspecific cell interactions, as the functioning of heat and ROS does not make a distinction between normal and bacterial cells.…”

Section: Doi: 101002/adtp201900052mentioning

confidence: 99%

Glycosylated Copper Sulfide Nanocrystals for Targeted Photokilling of Bacteria in the Near‐Infrared II Window

Hou

Mahadevegowda

Cuong

et al. 2019

Advanced Therapeutics

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Photothermal and photodynamic therapies are established as alternative approaches to combating bacterial infections; however, the heat and reactive oxygen species generated by the photoagents act on both normal and bacterial cells. A targeting strategy is thus required to minimize side effects and enhance the antibacterial efficiency. Glycoconjugates specifically interacting with bacterial lectins have emerged as a new class of materials for targeting bacteria. In this paper, galactosylated plasmonic copper sulfide nanocrystals (Cu 2−x S NCs) are used to target Pseudomonas aeruginosa via galactose-LecA interactions and kill the bacteria by simultaneous photothermal and photodynamic therapy. Galactosylated Cu 2−x S NCs are obtained by functionalizing the nanocrystals with tri-thiogalactoside glycoclusters. The excellent specificity of galactosylated nanoparticles toward LecA with a LecA-deficient P. aeruginosa strain as the control is first demonstrated. Afterward, a laser in the near-infrared II window is used to kill the bacteria, and the critical role of targeted binding in efficient killing of bacteria is highlighted. This approach can be readily generalized to the targeting of other pathogens which have highly specific carbohydrate-binding lectins.

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“…Unlike their small molecular probes, nanotechnology‐based bacteria probes are commonly composed of a recognition moiety that targets bacteria specifically, and a transducer that release a measurable signal once the bacteria bounded ( Scheme 2 ). The commonly used recognition strategies include antibody, aptamer, bacteriophage, and electrostatic interaction (Scheme ). Among them, antibody, aptamer, and bacteriophage can specifically target bacteria and have been extensively investigated .…”

Section: Infection Detectionmentioning

confidence: 99%

“… The commonly used recognition strategies include antibody, aptamer, bacteriophage, and electrostatic interaction (Scheme ). Among them, antibody, aptamer, and bacteriophage can specifically target bacteria and have been extensively investigated . The recognition moieties could be immobilized onto the surfaces of nanoparticles via either physical absorption or chemically covalent bonding .…”

Section: Infection Detectionmentioning

confidence: 99%

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Recent Advances and Future Prospects on Adaptive Biomaterials for Antimicrobial Applications

Liu

et al. 2019

Macromolecular Bioscience

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Bacterial infection is becoming the biggest threat to human health. The scenario is partly due to the ineffectiveness of the conventional antibiotic treatments against the emergence of multidrug‐resistant bacteria and partly due to the bacteria living in biofilms or cells. Adaptive biomaterials can change their physicochemical properties in the microenvironment of bacterial infection, thereby facilitating either their interactions with bacteria or drug release. The trends in treating bacterial infections using adaptive biomaterials‐based systems are flourishing and generate innumerous possibility to design novel antimicrobial therapeutics. This feature article aims to summarize the recent developments in the formulations, mechanisms, and advances of adaptive materials in bacterial infection diagnosis, contact killing of bacteria, and antimicrobial drug delivery. Also, the challenges and limitations of current antimicrobial treatments based on adaptive materials and their clinical and industrial future prospects are discussed.

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Integrating recognition elements with nanomaterials for bacteria sensing

Cited by 289 publications

References 50 publications

Chiral Upconversion Heterodimers for Quantitative Analysis and Bioimaging of Antibiotic‐Resistant Bacteria In Vivo

Chiral Upconversion Heterodimers for Quantitative Analysis and Bioimaging of Antibiotic‐Resistant Bacteria In Vivo

Glycosylated Copper Sulfide Nanocrystals for Targeted Photokilling of Bacteria in the Near‐Infrared II Window

Recent Advances and Future Prospects on Adaptive Biomaterials for Antimicrobial Applications

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