Cell Proliferation Response to Sulphydryl in Man.

Reimann, Stanley P.; Hammett, Frederick S.

doi:10.3181/00379727-27-4584

Cited by 21 publications

(2 citation statements)

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“…Odor was also a concern. While these findings were striking, no information was presented on the healing rate of so‐called “normal” (i.e., nonindolent) wounds although this compound appeared to work with similar effectiveness in the 1929 report by Reimann and Hammett using animal models.…”

Section: Early Product Testing and Applicationsmentioning

confidence: 98%

“…The first SH compound tested for wound healing in a clinical setting was thiocresol. A preliminary note was reported in 1929 by Reimann and Hammett with a more detailed subsequent report given by Reimann . When a wound (i.e., skin cut) occurs, Reimann stated that cells soon initiate division and the process continues until the wound is healed.…”

Section: Early Product Testing and Applicationsmentioning

confidence: 99%

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Historical foundations of wound healing and its potential for acceleration: dose‐response considerations

Calabrese

2013

Wound Repair Regeneration

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This paper provides a detailed historical assessment of the origin and developmental progress of the concept of wound healing and its attempted acceleration from its start in the beginning of the 20th century to approximately 1960. Emphasis is placed on the development of cell culture in the assessment of wound healing and in attempts to validate experimental findings via clinical research. Of particular interest were the observations that wound healing could be accelerated in the 30-50% range with the dose response displaying biphasic characteristics consistent with the hormesis dose-response model. Such findings set the stage for the hormetic dose-response revolution that is occurring within the biological and biomedical sciences, including wound healing, whereby considerable research now supports the capacity for endogenous and exogenous agents to accelerate the process of wound healing and its functional performance.

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Section: Early Product Testing and Applicationsmentioning

confidence: 98%

Section: Early Product Testing and Applicationsmentioning

confidence: 99%