Certain Phases of Sulfur Metabolism of the Skin

Klauder, Joseph V.

doi:10.1001/archderm.1936.01470160015003

Cited by 16 publications

(2 citation statements)

References 13 publications

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“…Methionine is also essential for fetus development, and infants require sulfur amino acid levels twice as those needed by adults [36]. The high requirements for sulfur amino acids may derive from high levels of polyamine synthesis and the higher sulfur content of the skin in infants than in adults [37, 38]. Thus, amino acid supplementation should be adopted in humans if it is difficult to achieve adequate amount of amino acids by just consuming cereals from the daily diet.…”

Section: Discussionmentioning

confidence: 99%

A Novel Concept of Amino Acid Supplementation to Improve the Growth of Young Malnourished Male Rats

Furuta¹,

Murakami²

2018

Ann Nutr Metab

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Backgrounds/Aims: This study was aimed at understanding the relationship between plasma amino acids and protein malnutrition and at determining whether amino acid supplementation associated with malnutrition and growth improves linear growth in growing rats. Methods: Body length and plasma amino acids were measured in young male rats that were fed the following diet for 3 weeks, mimicking a low and imbalanced protein diets based on maize, a major staple consumed in developing countries: a 70% calorically restricted cornmeal-based diet (C), C + micronutrients (CM), CM + casein (CMC), CM + soy protein (CMS) or CMS + 0.3% lysine. Results: A correlation analysis of linear growth and plasma amino acids indicated that lysine, tryptophan, branched-chain amino acids, methionine, and phenylalanine significantly correlated with body length. Supplementation with these 5 amino acids (AA1) significantly improved the body length in rats compared to CMC treatment whereas, nitrogen-balanced amino acid supplemented controls (AA2) did not (CM +1.2 ± 0.2, CMC +2.7 ± 0.3, CMS +2.1 ± 0.3, AA1 +2.8 ± 0.2, and AA2 +2.5 ± 0.3 cm). Conclusion: With securing proper amino acid balance, supplementing growth-related amino acids is more effective in improving linear growth in malnourished growing male rats. Analysis of the correlation between plasma amino acids and growth represents a powerful tool to determine candidate amino acids for supplementation to prevent malnutrition. This technology is adaptable to children in developing countries.

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Section: Discussionmentioning

confidence: 99%

A Novel Concept of Amino Acid Supplementation to Improve the Growth of Young Malnourished Male Rats

Furuta¹,

Murakami²

2018

Ann Nutr Metab

View full text Add to dashboard Cite

show abstract

“…Mindful of this metabolic state of affairs and after extensive investigation, Sturman (8) concluded that methionine is essential for the developing human fetus and infant but nonessential for the mature human. The sulfur content of skin, the largest bodily organ, in infants is twice as high in the first 4 years of life than in later childhood or adulthood (70). The observation of a high content of sulfur in the skin of the young has also been made in animals (71).…”

Section: Essential Versus Nonessential Amino Acids In Kwashiorkormentioning

confidence: 94%