Historical foundations of wound healing and its potential for acceleration: dose‐response considerations

Abstract

This paper provides a detailed historical assessment of the origin and developmental progress of the concept of wound healing and its attempted acceleration from its start in the beginning of the 20th century to approximately 1960. Emphasis is placed on the development of cell culture in the assessment of wound healing and in attempts to validate experimental findings via clinical research. Of particular interest were the observations that wound healing could be accelerated in the 30-50% range with the dose response displaying biphasic characteristics consistent with the hormesis dose-response model. Such findings set the stage for the hormetic dose-response revolution that is occurring within the biological and biomedical sciences, including wound healing, whereby considerable research now supports the capacity for endogenous and exogenous agents to accelerate the process of wound healing and its functional performance.

A Comparative Study of Stapled Vs Subcuticular Vs Simple Interrupted Closure of Inguinal Hernia Incision

“…Wound complications are one of the major sources of morbidity after any surgical procedures and can prolong the inpatient stay or lead to re-admission (1).…”

The Historical Use of Radiotherapy in the Treatment of Sinus Infections

“…Page 309 Osmond 1923 "The attention of the writer was called to this subject when patients were relieved from pain in the forehead for a time after the making of radiograms for the diagnosis of a suspected frontal sinusitis". Page 374 Table IV continues on the next page 0.3 to 0.7 Gy maximally decreased inflammation, reduced pain, and facilitated the healing process via the enhancement of phagocytosis and via various steps in the process of wound healing (Calabrese, 2013b). In the case of sinus infection, x-ray therapy was determined to be a useful vehicle, espe- …”

Genetic parameters of wound healing in patients with neuropatic diabetic foot ulcers

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