Cell proliferation and 3H-proline incorporation in periodontal ligament exposed to mechanical stress

Kunz, J; Plascke, C.; Duncker, M.

doi:10.1016/s0232-1513(88)80023-9

Cited by 5 publications

(1 citation statement)

References 16 publications

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“…Following release of orthodontic force, transseptal fibers are reported to remain stretched for a n extended period (Reitan, 19591, while glycosaminoglycans accumulate within adjacent gingival connective tissues (Ronnerman et al, 1980). There are several studies of collagenous protein remodeling within the rodent periodontium and gingiva during active tooth movement (Crumley, 1964;Koumas and Matthews, 1969;Baurnrind and Buck, 1970;Rippin, 1976Rippin, , 1978Diaz, 1978;Kunz et al, 1988), but no reports of this remodeling following removal of orthodontic forces subsequent to establishment of a new tooth position.…”

Section: Introductionmentioning

confidence: 99%

Distribution of ³H‐proline within transseptal fibers of the rat following release of orthodontic forces

Row

Johnson

1990

Am. J. Anat.

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Maxillary right first molar teeth of rats were tipped mesially with an orthodontic appliance for 2 weeks (experimental group), 3H-proline was injected, and orthodontic forces were removed 6 hr later (time 0). The contralateral molar teeth of treated (internal control group) and age- and weight-matched untreated animals (external control group) were also studied. Diastemata were created between the molar teeth by the orthodontic appliance, and transseptal fibers between first and second (P less than 0.001) and second and third molars (P less than 0.005) were significantly lengthened as compared to external and internal controls at time 0. Diastemata between molar teeth were closed 5 days after removal of orthodontic force. Transseptal fibers adjacent to the source of the orthodontic force (mesial region) had the highest mean number of 3H-proline-labeled proteins at time 0 and at all times following removal of the force (P less than 0.001), and had the highest rate of labeled protein removal (P less than 0.001). Half-lives for removal of 3H-proline-labeled transseptal fiber proteins were significantly greater in mesial and distal regions and significantly less in middle regions of experimentals than in corresponding regions of external controls (P less than 0.001). These data suggest the following: 1) transseptal fibers adjust their length by rapid remodeling in regions experiencing a tensile force; 2) collagenous protein turnover within the middle third of the transseptal fibers is more rapid subsequent to release of orthodontic force than during normal physiologic drift, suggesting that this region adapts rapidly to changes in adjacent tooth position and that these fibers do not play a significant role in relapse of orthodontically relocated teeth; and 3) significant differences in turnover rates of 3H-proline-labeled transseptal ligament proteins of external and internal control quadrants suggest that tooth movement produces both local and systemic effects on collagenous protein metabolism.

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Section: Introductionmentioning

confidence: 99%

Distribution of ³H‐proline within transseptal fibers of the rat following release of orthodontic forces

Row

Johnson

1990

Am. J. Anat.

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Zur Beeinflussung des mechanisch belasteten Parodonts während orthodontisch induzierter Zahnbewegung mit nichtsteroidalen Antiphlogistika im Tierexpeeiment

Kleber

Kogel

Kögel

1991

Fortschritte der Kieferorthopädie

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In a total of 123 female adult Wistar rats the first upper molar was moved by orthodontics for more than 28 days. This orthodontically stimulated tooth movement was influenced by local application of Cu-salicylate, Cu-indomethacin or epsilon-Aminocapronacid. The application of Cu-salicylate and Cu-indomethacin caused reduced tooth movement, a decrease in osteoclasts in the pressure region of the periodontium, and an increase of hydroxyproline in the desmodont. Generally, the local application of Cu-nonsteroidal antiphlogistics seems to stabilize the experimentally induced tooth movement.

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Role of MAPK in mechanical force-induced up-regulation of type I collagen and osteopontin in human gingival fibroblasts

et al. 2008

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In addition to periodontal ligament, the gingival plays an important role in alveolar bone remodeling induced by physiological and mechanical stimuli. However, there are few reports showing the cellular responses of human gingival fibroblasts (HGF) to a mechanical force. This study examined the effects of centrifugal force on the proliferation of the bone tissue components, such as type I collagen (COL I), osteopontin (OPN), and osteonectin (ONN) in the HGF. The roles of extracellular signal-regulated kinase (ERK), c-Jun-N-terminal kinase (JNK), and p-38 kinase were also investigated. Centrifugal force induced cell cycle arrest in the G(1) phase without any cytotoxic effects and increased the levels of COL I and OPN expression in the cells but had no effect on ONN. The force-induced up-regulation of COL I was found to be mediated by both the ERK-c-Fos-COL I and JNK-c-Jun-COL I pathways, while that of OPN was mediated only by the ERK-mediated pathway. Our present findings suggest that centrifugal force up-regulates COL I and OPN expression in HGF, where both ERK and JNK play indispensable roles.

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Cell proliferation and 3H-proline incorporation in periodontal ligament exposed to mechanical stress

Cited by 5 publications

References 16 publications

Distribution of ³H‐proline within transseptal fibers of the rat following release of orthodontic forces

Distribution of ³H‐proline within transseptal fibers of the rat following release of orthodontic forces

Zur Beeinflussung des mechanisch belasteten Parodonts während orthodontisch induzierter Zahnbewegung mit nichtsteroidalen Antiphlogistika im Tierexpeeiment

Role of MAPK in mechanical force-induced up-regulation of type I collagen and osteopontin in human gingival fibroblasts

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Cell proliferation and 3H-proline incorporation in periodontal ligament exposed to mechanical stress

Cited by 5 publications

References 16 publications

Distribution of 3H‐proline within transseptal fibers of the rat following release of orthodontic forces

Distribution of 3H‐proline within transseptal fibers of the rat following release of orthodontic forces

Zur Beeinflussung des mechanisch belasteten Parodonts während orthodontisch induzierter Zahnbewegung mit nichtsteroidalen Antiphlogistika im Tierexpeeiment

Role of MAPK in mechanical force-induced up-regulation of type I collagen and osteopontin in human gingival fibroblasts

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Distribution of ³H‐proline within transseptal fibers of the rat following release of orthodontic forces

Distribution of ³H‐proline within transseptal fibers of the rat following release of orthodontic forces