Cell membrane-based biomimetic nanosystems for advanced drug delivery in cancer therapy: A comprehensive review

Zhao, Jianzhou; Ruan, Jian; Lv, Guangyao; Shan, Qi; Fan, Zhiping; Wang, Hongbo; Du, Yuan; Ling, Longbing

doi:10.1016/j.colsurfb.2022.112503

Cited by 16 publications

(13 citation statements)

References 167 publications

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“…White blood cells (WBCs) are immune cells that are responsible for protecting the body from infection, engulfing foreign bacteria and repairing tissue injury 77 . Membranes from certain types of WBCs, such as T cells, macrophages, neutrophils, and dendritic cells (DCs), have widely been used to fabricate biomimetic NPs 78 . Compared with bare NPs, WBC membrane-coated NPs can reduce opsonization and leverage the self-recognition mechanism of the WBC membrane to delay phagocytic uptake 79 .…”

Section: Engineered Biological Membrane-derived Npsmentioning

confidence: 99%

Engineered biomembrane-derived nanoparticles for nanoscale theranostics

Wu¹,

Zhang²,

Yan³

et al. 2023

Theranostics

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Currently, biological membrane-derived nanoparticles (NPs) have shown enormous potential as drug delivery vehicles due to their outstanding biomimetic properties. To make these NPs more adaptive to complex biological systems, some methods have been developed to modify biomembranes and endow them with more functions while preserving their inherent natures. In this review, we introduce five common approaches used for biomembrane decoration: membrane hybridization, the postinsertion method, chemical methods, metabolism engineering and gene engineering. These methods can functionalize a series of biomembranes derived from red blood cells, white blood cells, tumor cells, platelets, exosomes and so on. Biomembrane engineering could markedly facilitate the targeted drug delivery, treatment and diagnosis of cancer, inflammation, immunological diseases, bone diseases and Alzheimer's disease. It is anticipated that these membrane modification techniques will advance biomembrane-derived NPs into broader applications in the future.

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Section: Engineered Biological Membrane-derived Npsmentioning

confidence: 99%

Engineered biomembrane-derived nanoparticles for nanoscale theranostics

Wu¹,

Zhang²,

Yan³

et al. 2023

Theranostics

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“…These cells may be paired with therapeutics and synthetic nanocarriers to tailor the next-generation drug delivery method in the guise of biomimetic nanocarriers, improving overall therapeutic efficiency. 139 Currently, biomimetic cell membrane-coated NPs drug delivery techniques have been developed and shown enhanced therapy effectiveness against inflammatory diseases and cancer, due to their ''self'' biocompatible character and precise accumulation in desired organs and tissues. [140][141][142][143] Of significance, in the therapy of sepsis, inflammatory cytokines, and lipopolysaccharide are assimilated by macrophage membrane-coated NPs to govern and inhibit local inflammatory reactions.…”

Section: Lipid-based Nanomaterialsmentioning

confidence: 99%

Section: Natural Biomaterial-based Nanomedicine Systems For Immunomod...mentioning

confidence: 99%

Biomaterial-based strategies for immunomodulation in IBD: current and future scenarios

Jori¹,

Chaudhary

Rashid

et al. 2023

J. Mater. Chem. B

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“…Therefore, developing novel, safe, and highly efficient techniques to cure cancers has attracted great attention from scientists worldwide. Targeted drug delivery using nanoparticles as carriers is a commonly used method for prolonging circulation time in blood vessels, improving the efficiency of cancer therapies, and reducing the injection dose and side effects. − In the past few decades, although numerous manmade drug delivery nanosystems with different physicochemical properties, such as superparamagnetic iron oxide nanoparticles, , biomimetic nanosystems − (e.g., cell membrane-coated nanoparticles), tumor microenvironment-sensitive nanosystems , (e.g., pH-responsive nanoparticles), and extrinsic stimuli-sensitive nanosystems, have been intensively investigated, these delivery nanosystems are hard to self-direct in the blood stream and difficult to migrate into tumors’ hypoxia regions and overcome the cancer cell drug resistance. ,− In addition, most manmade nanosystems are unsuitable for treating all tumors due to tumors’ heterogeneity …”

Section: Introductionmentioning

confidence: 99%

Magnetotactic Bacteria-Based Drug-Loaded Micromotors for Highly Efficient Magnetic and Biological Double-Targeted Tumor Therapy

Wang

Qin

Liu

et al. 2023

ACS Appl. Mater. Interfaces

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Bacteria-mediated cancer therapy has attracted much attention in recent years. However, using magnetotactic bacteria as both a drug carrier and a drug for cancer therapy has never been reported. Herein, we incorporated a photosensitizer chlorin e6 (Ce6) into the M. magneticum strain AMB-1 through a chemical bond or physical blending. A chemical reaction was finally selected for fabricating AMB-1/Ce6 micromotors, as such micromotors exhibited high drug payload and normal bacterial activities. An interesting finding is that AMB-1 is not only an excellent drug carrier but also a unique drug that could inhibit mouse tumor growth. We also, for the first time, demonstrated that AMB-1 is a photosensitizer. Under laser irradiation, micromotors killed cancer cells with high efficiency due to the high-level reactive oxygen species generated by the micromotors. Micromotors could target the hypoxic and normoxic regions in vitro via both the active swimming of AMB-1 and external magnetic field guidance. Micromotors showed high tumor-homing ability owing to the above double targeting mechanisms. After injection with the micromotors followed by magnetic field guidance and laser irradiation, the growth of mouse tumors was significantly inhibited owing to the AMB-1-based biotherapy and phototoxicity of AMB-1 and Ce6. This micromotor-mediated tumor-targeted therapy strategy may be a great platform for treating many types of solid tumors.

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Cell membrane-based biomimetic nanosystems for advanced drug delivery in cancer therapy: A comprehensive review

Cited by 16 publications

References 167 publications

Engineered biomembrane-derived nanoparticles for nanoscale theranostics

Engineered biomembrane-derived nanoparticles for nanoscale theranostics

Biomaterial-based strategies for immunomodulation in IBD: current and future scenarios

Magnetotactic Bacteria-Based Drug-Loaded Micromotors for Highly Efficient Magnetic and Biological Double-Targeted Tumor Therapy

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