Cell Mediated Lympholysis in Man. The HL‐A Third Locus Antigen, AJ (W20) as Sensitizing and/or Target Determinant

Kristensen, Tom; Grunnet, Niels; Kissmeyer‐Nielsen, F.

doi:10.1111/j.1399-0039.1975.tb00637.x

Cited by 13 publications

(3 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(2) The variance may be caused by the influence of the third series antigens, which we have neglected in this study. This explanation, however, may have minor importance because another study (Kristensen et al 1975a) shows that the AJ antigen of the third series does not seem to have an independent function, but most probably only a modifying effect on antigens from the FOUR series.…”

Section: Discussionmentioning

confidence: 94%

Cell Mediated Lympholysis in Man. Patterns of Killing Power in Relation to the HL‐A System

1975

Self Cite

View full text Add to dashboard Cite

In general it can be said that the HL-,4 (LA and FOUR) antigens seem to be of major qualitative and partly quantitative importance for the degree of destruction in Cell Mediated Lymphoiysis ( C M L ) . This has been established by analyses of 1299 effector/target combinations involving 97 different healthy individuals.The main observation is that the cytolytic capacity of MLC effectors is positively ranked with the number of HL-A (LA and FOUR) antigens introduced by the incompatibility between stimulator, effector and target lymphocytes. However, the fact that not all cytolytic situations can be explained by the HL-A system stresses that other specific antigens (Target Determinants) may interfere with the Cell Mediated Lympholysis.

show abstract

Section: Discussionmentioning

confidence: 94%

Cell Mediated Lympholysis in Man. Patterns of Killing Power in Relation to the HL‐A System

1975

Self Cite

View full text Add to dashboard Cite

show abstract

“…It is thus conceivable that HLA-C antigens may explain at least some of our findings. The impact of HLA-C antigens in CML has so far only been investigated by our grodp (Kristensen et al 1975. We found that the HLA-C antigens are generally weak, but that the strength of each antigen must be evaluated separately.…”

Section: Discussionmentioning

confidence: 93%

Typing by cytotoxic lymphocytes. Genetics of HLA‐non‐A, B, C determinants—family studies

et al. 1981

Self Cite

View full text Add to dashboard Cite

Some CTLs recognize HLA‐structures in a different way than antibodies, i.e. they may identify other epitopes than antibodies or may define genetically distinct structures. From population studies, in vitro educated CTLs were selected giving rise to significant lysis on PHA‐lymphoblasts in the absence of the sharing of HLA‐A, B, (C) determinants between stimulator and target lymphocytes. Based on pair‐wise correlations these CTLs form 3 clusters, identifying structures associated to HLA‐markers. Subsequent testing in 14 complete families of ± 4 children allowed the observations: (1) CML‐traits assigned on the basis of single CTLs often segregated in a non‐mendelian way or independent of HLA. (2) Assignments made on the basis of CTL‐clusters segregated with HLA. (3) in 2 informative HLA‐B/D, DR recombinant families, CML‐traits segregated with HLA‐B. (4) No haplotype could be assigned more than one CML‐trait.

show abstract

“…Arguments into the existence of a separate, unique C-locus in t h e H L A region a n d into alternative genetic organization of this region were brought u p in t h e former communication by Kristensen et al (1975b). These arguments are still valid and recognized.…”

Section: Discussionmentioning

confidence: 99%

Cell Mediated Lympholysis in Man. The Impact of HLA‐C Antigens

1976

Self Cite

View full text Add to dashboard Cite

From a population of individuals, all HLA‐A, B, and C tissue typed in relation to the Sixth International Histocompatibility Workshop, an experimental investigation has been performed to study the influence of the HLA‐Cw1, w2, w3, w4, and w5 antigens in the Cell Mediated Lympholysis (CML) test. The average cytolysis obtained due to allogenic attack of one HLA‐C antigen equals 12.6%, but like the HLA‐A and B antigens, HLA‐C antigens exhibit differences with regard to sensitizing and target potential. This indicates either a heterogeneity of these antigens or the existence of separate CML determinants. It is concluded that the HLA‐C antigens may account for the cytolysis observed in some of the combinations exhibiting cytolysis which cannot be explained by the HLA‐A and B antigens.

show abstract

Cell Mediated Lympholysis in Man. The HL‐A Third Locus Antigen, AJ (W20) as Sensitizing and/or Target Determinant

Cited by 13 publications

References 24 publications

Cell Mediated Lympholysis in Man. Patterns of Killing Power in Relation to the HL‐A System

Cell Mediated Lympholysis in Man. Patterns of Killing Power in Relation to the HL‐A System

Typing by cytotoxic lymphocytes. Genetics of HLA‐non‐A, B, C determinants—family studies

Cell Mediated Lympholysis in Man. The Impact of HLA‐C Antigens

Contact Info

Product

Resources

About