Cell adhesion to collagenous matrices

McCarthy, James B.; Vachhani, Bina; Iida, Joji

doi:10.1002/(sici)1097-0282(1996)40:4<371::aid-bip3>3.0.co;2-t

Cited by 42 publications

(20 citation statements)

References 97 publications

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“…Specifically, β‐1‐integrins are involved in macrophage adhesion and fusion into foreign body giant cells 34. Furthermore, several β‐1‐integrins serve as collagen receptors that mediate cell adhesion to collagen surfaces such as collagen‐coated prostheses 35, 36. In particular, α‐2‐β‐1‐integrin is the primary receptor for collagen type I and expressed, for example, on platelets, epithelial cells, endothelial cells, and lymphocytes 35.…”

Section: Discussionmentioning

confidence: 99%

Local tissue reaction and differentiation of the prosthesis‐specific antibody response following functional implantation of vascular grafts in pigs

Zippel¹,

Wilhelm

Hoene

et al. 2007

J Biomed Mater Res

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The study was aimed at investigating the local tissue reactions through a histological examination of beta-1-integrin expression and neointima formation, and humoral immune responses by detection of prosthesis-specific antibodies, after functional implantation of vascular prostheses. In three groups of pigs, the infrarenal aorta was replaced with segments of collagen-impregnated Dacron-prostheses: M-prosthesis--medium primary porosity, double velour layer, crimping; C-prosthesis--low primary porosity, no velour, crimping; T-prosthesis--high primary porosity, no velour, no crimping. For each prosthesis type, one series with four animals was used for examining the tissue reactions, and a second series with eight animals was used to study the antibody response, both until 116 days postoperative. In the first three weeks, the M-prosthesis caused the highest tissue reactions and the highest antipolyester antibodies, but the lowest anticollagen antibodies, whereas the T-prosthesis caused the highest anticollagen antibodies, but the least tissue response and antipolyester antibodies in the early phase. On day 116, the C-prosthesis caused the highest tissue reactions and highest polyester-specific antibodies. These results indicate a possible association between local inflammatory reactions and humoral immune responses, influenced by properties of vascular grafts.

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Section: Discussionmentioning

confidence: 99%

Local tissue reaction and differentiation of the prosthesis‐specific antibody response following functional implantation of vascular grafts in pigs

Zippel¹,

Wilhelm

Hoene

et al. 2007

J Biomed Mater Res

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“…Previous histologic studies in both preclinical and human aneurysms treated with platinum coils show a dearth of collagen synthesis within the aneurysm cavity and along the neck-parent artery interface ( 28 ). Collagen synthesis is a central part of wound healing, providing both a structural matrix for the healing wound, as well as a surface or substrate for adhesion of cells to the injured area ( 29,30 ). As such, it seems logical that collagen synthesis would be associated with robust healing in aneurysms.…”

Section: Molecular Imaging: Gene Expression In Healed Aneurysms Aftermentioning

confidence: 99%

Differential Gene Expression in Well-healed and Poorly Healed Experimental Aneurysms after Coil Treatment

Kadirvel¹,

Ding²,

Dai³

et al. 2010

Radiology

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Purpose:To compare gene expression patterns between well-healed and poorly healed aneurysms following coil embolization in a rabbit model. Materials and Methods:The Institutional Animal Care and Use Committee approved all procedures before initiation of the study. Elastaseinduced, saccular aneurysms were created in rabbits and embolized by using platinum microcoils. Group 1 aneurysms were densely packed (volumetric packing density, . 30%) to achieve good healing, whereas group 2 aneurysms were loosely packed (volumetric packing density, , 20%), which yields poor healing. At 2 or 4 weeks after implantation, samples were harvested. RNA was isolated separately from the necks and domes of the aneurysms and analyzed by using a microarray containing 294 rabbit genes. Genes with signifi cant differences between groups ( P , .05; false discovery rate, , 0.1; fold change, Ն 1.2 and Յ 0.8) were considered differentially expressed.

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“…Collagen4–6 has been extensively described as a beneficial material in tissue engineering due to its biocompatibility, biodegradability, low antigenicity, and high tensile strength 7, 8. Moreover, it presents amino acid sequences of arginine–glycine–aspartate (RGD sequences),6, 9 which are responsible for cellular recognition and adhesion. However, collagen scaffolds in their pure form have some drawbacks as their poor mechanical strength7 can interfere with the re‐establishment of the initial tissue characteristics.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, improvements in the physical, chemical, and biologic properties of collagen are necessary to overcome those inadequacies, and several approaches have been tried. The addition of other materials such as hydroxyapatite6, 10 and calcium phosphate11 to collagen scaffolds serves to improve mechanical integrity and degradation rate, while the use of growth factors,12, 13 glycosaminoglycans,14 and elastin5 increases bone formation.…”

Section: Introductionmentioning

confidence: 99%

In vitro analysis of anionic collagen scaffolds for bone repair

Moreira

Santos

et al. 2004

J Biomed Mater Res

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Collagen has been extensively described as a beneficial material in bone tissue engineering due to its biocompatibility, biodegradability, low antigenicity, and high tensile strength. However, collagen scaffolds in their pure form have some drawbacks and improvements in the physical, chemical, and biologic properties of collagen are necessary to overcome those inadequacies. Recently, the selective hydrolysis of carboxyamides of asparagine and glutamine residues of collagen has been employed to increase the number of negative sites and enhance the piezoelectric properties of collagen. Anionic collagen scaffolds were prepared by use of a hydrolysis treatment for either 24 h [bovine pericardium (BP 24)] or 48 h (BP 48). Bovine osteoblasts were cultured on them and on native matrices to understand the cellular interactions responsible for the good osteoconductivity and biocompatibility reported with in vivo tests. Based on the data obtained on cell adhesion, alkaline phosphatase (ALP) and extracellular matrix macromolecule production, and cellular proliferation through histological analysis, we may conclude that the materials tested reveal sufficient biocompatibility level for bone repair. Further, the evidence of some connection between ALP activity and the mineralization process should be emphasized. BP 48 presented the most promising results stimulating in vitro mineralization, ALP production, and possible osteoblast differentiation.

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Cell adhesion to collagenous matrices

Cited by 42 publications

References 97 publications

Local tissue reaction and differentiation of the prosthesis‐specific antibody response following functional implantation of vascular grafts in pigs

Local tissue reaction and differentiation of the prosthesis‐specific antibody response following functional implantation of vascular grafts in pigs

Differential Gene Expression in Well-healed and Poorly Healed Experimental Aneurysms after Coil Treatment

In vitro analysis of anionic collagen scaffolds for bone repair

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