Cell adhesion molecules in coronary artery disease

Jang, Yangsoo; Lincoff, A. Michael; Plow, Edward F.; Topol, Eric J.

doi:10.1016/0735-1097(94)90162-7

Cited by 374 publications

(219 citation statements)

References 92 publications

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“…24 On stimulation, P-selectin is rapidly translocated to the cell surface, where it mediates adhesion to carbohydrate ligand(s) on leukocytes. 25 P-selectin is involved in many acute inflammatory conditions mediated by neutrophils, 26,27 and because it regulates monocyte and T-lymphocyte emigration from the blood stream, 22,28 it may also be involved in chronic inflam- Ϫ/Ϫ P ϩ/ϩ mice (C) but not in lesions from apoE Ϫ/Ϫ P Ϫ/Ϫ mice (D). E and F, Sections were stained with oil red O, hematoxylin, and light green.…”

Section: Discussionmentioning

confidence: 99%

Prominent Role of P-Selectin in the Development of Advanced Atherosclerosis in ApoE-Deficient Mice

2000

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Background-Adhesive interactions between leukocytes and endothelial cells are characteristic of the development of atherosclerotic lesions, but the receptors involved remain to be defined. P-selectin is an adhesion receptor expressed on activated endothelial cells or platelets and was shown to be involved in fatty streak formation in LDL receptor-deficient mice on an atherogenic diet. The main purpose of this study is to examine the role of P-selectin in the spontaneous development of advanced atherosclerosis in apoE-deficient mice. Methods and Results-We intercrossed P-selectin-deficient mice with mice lacking apoE and compared lesion development in apoE-deficient mice with P-selectin (apoE Ϫ/Ϫ P ϩ/ϩ ) and without P-selectin (apoE Ϫ/Ϫ P Ϫ/Ϫ ) that were fed normal mouse chow. At 4 months of age, apoE Ϫ/Ϫ P Ϫ/Ϫ mice had 3.5-fold smaller aortic sinus lesions than apoE Ϫ/Ϫ P

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Section: Discussionmentioning

confidence: 99%

Prominent Role of P-Selectin in the Development of Advanced Atherosclerosis in ApoE-Deficient Mice

2000

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“…In contrast to other adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and P-selectin that are synthesized and released from endothelial cells, as well as from other cells including fibroblasts, smooth muscle cells and platelets, E-selectin is produced specifically by endothelial cells (9). In this regard, E-selectin has been subject to several studies in terms of its relation to carotid atherosclerosis and the risk of coronary heart disease (10-13) given that higher likelihood of E-selection to be a specific marker for endothelial cell dysfunction and thereby the development of atherosclerosis than other adhesion molecules (14).…”

Section: Introductionmentioning

confidence: 99%

Circulating E-selectin levels and insulin resistance are associated with early stages of atherosclerosis in nonfunctional adrenal incidentaloma

Delibaşı

Karbek²,

Bozkurt

et al. 2015

Arch. Endocrinol. Metab.

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Objective: To evaluate circulating E-selectin levels in patients with nonfunctional adrenal incidentaloma (NFA) in relation to insulin resistance and early atherosclerosis. Subjects and methods: A total of 40 patients with NFA (mean [SD] age: 55.6 [10.7] years; 70% were females) and 35 controls (mean [SD] age: 51.5 [8.1] years; 71.4% were females) selected from age-, gender-and body mass index (BMI)-matched healthy subjects were enrolled. Serum hsCRP, lipid profile, insulin levels and the homeostasis model assessment of insulin resistance (HOMA-IR) were evaluated. High-resolution Bmode ultrasonography was performed. Serum levels of E-selectin were evaluated by enzyme-linked immunosorbent assay. Results: Patients with NFA had significantly higher values for E-selectin (14.9 (4.8) vs. 12.2 (4.1) ng/mL, p < 0.01) and CIMT (0.6 (0.1) vs. 0.5 (0.1) mm, p < 0.05) than controls. Serum E-selectin levels showed a statistically significant association with hsCRP (r = 0.751, p < 0.001), HOMA-IR (r = 0.575, p < 0.001) and CIMT (r = 0.762, p < 0.001). CIMT (Carotid intima media thickness) was increased in patients with NFA patients with NFA were more insulin resistant than controls and statistically significant relationship was found between size of tumor and HOMA-IR (r = 0.361, p < 0.001). Conclusion: In conclusion, based on significantly higher values for E-selectin, CIMT and HOMA-IR in patients with NFA than controls along with significant correlation of E-selectin levels to CIMT, HOMA-IR and hs-CRP, our findings seems to indicate an increased risk of early atherosclerosis and impaired endothelial function in NFA patients, particularly in case of insulin resistance. Arch Endocrinol Metab. 2015;59(4):310-7

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“…1 Cellular adhesion molecules (CAMs) are poorly expressed by the resting endothelium, but they are upregulated during atherogenesis. 2 Soluble forms of some CAMs can be found in plasma; it has been suggested that elevated plasma levels of some CAMs may be an index of endothelial activation 3 or even a molecular marker of early atherosclerosis. 4 Type 2 diabetes mellitus is associated with an increased risk of premature atherosclerosis, 5,6 and the circulating levels of some CAMs are higher in the diabetic patient.…”

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confidence: 99%

Circulating Adhesion Molecules in Humans

et al. 2000

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Background-We assessed the role of glucose and insulin in the regulation of circulating levels of soluble intercellular adhesion molecule-1 (sICAM-1) and vascular adhesion molecule-1 (sVCAM-1) in normal subjects and in patients with type 2 diabetes. Methods and Results-Plasma glucose concentrations were acutely raised in 10 normal subjects and 10 newly diagnosed, complication-free type 2 diabetic patients and maintained at 15 mmol/L for 2 hours. In normal subjects, plasma sICAM-1, but not sVCAM-1, levels rose significantly (PϽ0.01) at 1 hour and returned to basal values at 2 hours. In another study, octreotide was infused during the hyperglycemic clamp to block the release of endogenous insulin; this prevented the late fall of plasma sICAM-l levels observed in under control clamp conditions. The diabetic patients had plasma sICAM-1 levels significantly higher (PϽ0.01) than those of the control subjects; plasma sVCAM-1 levels were similar. Both sICAM-l and sVCAM-1 concentrations did not change significantly during the control hyperglycemic clamp; however, octreotide infusion increased plasma sICAM-1 levels, which remained significantly (PϽ0.05) above baseline during the whole clamp. In an additional 10 type 2 diabetic patients, overnight euglycemia (plasma glucose 5.5 mmol/L) obtained with the aid of an artificial pancreas or supplementation with L-arginine (10 g PO for 30 days), the natural precursor of NO, normalized the increased plasma sICAM-1 levels. Conclusions-Acute hyperglycemia increases circulating sICAM-1 levels in normal subjects, whereas the correction of hyperglycemia with insulin or L-arginine supplementation restored to normal levels the increased plasma sICAM-1 levels of type 2 diabetic patients.

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Cell adhesion molecules in coronary artery disease

Cited by 374 publications

References 92 publications

Prominent Role of P-Selectin in the Development of Advanced Atherosclerosis in ApoE-Deficient Mice

Prominent Role of P-Selectin in the Development of Advanced Atherosclerosis in ApoE-Deficient Mice

Circulating E-selectin levels and insulin resistance are associated with early stages of atherosclerosis in nonfunctional adrenal incidentaloma

Circulating Adhesion Molecules in Humans

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