Circulating E-selectin levels and insulin resistance are associated with early stages of atherosclerosis in nonfunctional adrenal incidentaloma

Abstract

Objective: To evaluate circulating E-selectin levels in patients with nonfunctional adrenal incidentaloma (NFA) in relation to insulin resistance and early atherosclerosis. Subjects and methods: A total of 40 patients with NFA (mean [SD] age: 55.6 [10.7] years; 70% were females) and 35 controls (mean [SD] age: 51.5 [8.1] years; 71.4% were females) selected from age-, gender-and body mass index (BMI)-matched healthy subjects were enrolled. Serum hsCRP, lipid profile, insulin levels and the homeostasis model assessment of insulin resistance (HOMA-IR) were evaluated. High-resolution Bmode ultrasonography was performed. Serum levels of E-selectin were evaluated by enzyme-linked immunosorbent assay. Results: Patients with NFA had significantly higher values for E-selectin (14.9 (4.8) vs. 12.2 (4.1) ng/mL, p < 0.01) and CIMT (0.6 (0.1) vs. 0.5 (0.1) mm, p < 0.05) than controls. Serum E-selectin levels showed a statistically significant association with hsCRP (r = 0.751, p < 0.001), HOMA-IR (r = 0.575, p < 0.001) and CIMT (r = 0.762, p < 0.001). CIMT (Carotid intima media thickness) was increased in patients with NFA patients with NFA were more insulin resistant than controls and statistically significant relationship was found between size of tumor and HOMA-IR (r = 0.361, p < 0.001). Conclusion: In conclusion, based on significantly higher values for E-selectin, CIMT and HOMA-IR in patients with NFA than controls along with significant correlation of E-selectin levels to CIMT, HOMA-IR and hs-CRP, our findings seems to indicate an increased risk of early atherosclerosis and impaired endothelial function in NFA patients, particularly in case of insulin resistance. Arch Endocrinol Metab. 2015;59(4):310-7

Research on the distribution spectrum of atherosclerotic plaques in patients with suspected coronary artery disease and the noninvasive screening model for coronary atherosclerosis burden

“…Both lipid deposition on the vessel wall and smooth muscle migration is closely related to time, and the occurrence has shown a significant time dependence. As age increases, changes in cells, enzymes, molecules, and other substances in the vascular wall will cause reduced vascular (19,20). Moreover, in the results of this study, the difference in TPS and SSS between different age groups was also statistically significant, and the older the age, the higher the score and the greater the degree of stenosis.…”

Correlation of E-selectin concentrations with carotid intima-media thickness and cardio-metabolic profile of mixed ancestry South Africans: a cross-sectional study

“…In contrast to these results, several studies have reported a significant association between E-selectin levels and CIMT. A study by Delibasi et al 27 found that in subjects with nonfunctional adrenal incidentalomas, E-selectin concentrations correlated significantly with both HOMA-IR and CIMT, while Baldassarre et al, 28 who examined subjects with only CVD but no diabetes, found that statin therapy significantly decreased both CIMT and E-selectin concentrations indicating the treatment's ability to improve endothelial dysfunction.…”