CD8+Cell-dominant Alveolitis in Pulmonary Sarcoidosis

Yamaguchi, Etsuro; Haneda, Hitoshi; Okazaki, Nozomu; Abe, Shosaku; Kawakami, Yoshikazu; Nojima, Takayuki

doi:10.1378/chest.95.1.228

Cited by 5 publications

(3 citation statements)

References 15 publications

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“…Several other groups have confirmed these observations, 33 ' 34 even if atypical cases with prevalence of CD8 + cells have also been described. 35 The prevalence of CD4 + lymphocytes confirmed at all sites involved by the disease appears consistent with the pathogenetic hypothesis of an abnormal distribution of T cells in sarcoidosis, as indicated by the consensus of several studies. 6,11,25,26,30 Another issue that we have addressed by in situ analysis with M Abs is how CD4 + lymphocytes accumulate in sarcoid lesions: they are either recruited from the periphery or produced by local proliferation.…”

Section: The Lymphoid Component T Cellssupporting

confidence: 84%

Immunology of Extrapulmonary Sarcoid Lesions

Semenzato¹,

Angi²,

Chilosi³

1992

Semin Respir Crit Care Med

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Section: The Lymphoid Component T Cellssupporting

confidence: 84%

Immunology of Extrapulmonary Sarcoid Lesions

Semenzato¹,

Angi²,

Chilosi³

1992

Semin Respir Crit Care Med

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“…Patients with sarcoidosis may have an alveolitis in which the CD8+ (suppressor/cytotoxic) T-lymphocyte is the predominant T-cell type [6,18,19]. AGOSTINI et al [20] recently reported that 3.8% of sarcoid patients in their series had a BAL fluid CD4/CD8 ratio <1.…”

mentioning

confidence: 99%

The CD4/CD8 ratio in BAL fluid is highly variable in sarcoidosis

Kantrow¹,

Meyer²,

Kidd³

et al. 1997

Eur Respir J

130

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T Th he e C CD D4 4/ /C CD D8 8 r ra at ti io o iin n B BA AL L f fl lu ui id d i is s h hi ig gh hl ly y v va ar ri ia ab bl le e i in n s sa ar rc co oi id do os si is s S.P. Kantrow*, K.C. Meyer**, P. Kidd*, G. Raghu* The CD4/CD8 ratio in BAL fluid is highly variable in sarcoidosis. S.P. Kantrow, K.C. Meyer, P. Kidd, G. Raghu. ERS Journals Ltd 1997. ABSTRACT: Patients with pulmonary sarcoidosis frequently have increased numbers of lymphocytes and a high ratio of CD4+ to CD8+ T-lymphocytes (CD4/CD8 ratio) in bronchoalveolar lavage (BAL) fluid. Some investigators have suggested that these parameters can be used to distinguish sarcoidosis from other types of interstitial lung disease with a high degree of reliability. However, we hypothesized that the BAL CD4/CD8 ratio measured during the initial diagnostic evaluation of patients with biopsy-proven sarcoidosis is highly variable.BAL lymphocytes were analysed via flow cytometry to determine the CD4/CD8 ratio in a population of 86 patients with histological and clinical evidence of sarcoidosis, who underwent BAL as part of their initial diagnostic evaluation.In these patients, the CD4/CD8 ratio ranged 0.5-37.3, with a median value of 3.35 (mean 6.49). The CD4/CD8 ratio was greater than 4 in only 36 (42%) subjects. Ten patients (12%) had a CD4/CD8 ratio less than 1. The distribution of CD4/CD8 ratios was similar in the presence or absence of BAL lymphocytosis.In conclusion, the CD4/CD8 ratio in bronchoalveolar lavage fluid is highly variable in biopsy-proven sarcoidosis. Bronchoalveolar lavage lymphocyte subset determination is a diagnostic test with low sensitivity for this disease.

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“…A predominance of CD8 ' T cells was found in the bronchoalveolar lavage of some asthmatic patients (44); however, biopsies of asthmatic airways did not show such a predominance of CD8 * T cells (45,46). CD8^ T cells are also found in puhnonary sardcoidosis (47).…”

Section: Cd8 ^ T Cells In Allergy and Infiammationmentioning

confidence: 99%