CD8<sup>+</sup> T cells in allergy

Kemeny, David M.; Díaz-Sánchez, David; Holmes, Barbara E.

doi:10.1111/j.1398-9995.1992.tb02243.x

Cited by 13 publications

(3 citation statements)

References 92 publications

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“…They reported a suppressive effect of early activated CD8 + T cells on IgE production that was transferable to naive animals (54). Interestingly, in vivo depletion of CD8 + T cells before sensitization with ricin and allergen did not lead to the predicted enhancement in IgE production, but instead, inhibited the development of IgE responses (55). From these experiments, they concluded that two distinct populations or different functional stages of CD8 + spleen T cells may exist, one which suppresses IgE responses through the production of IFN-~/ and the other which augments IgE responses by an unknown mechanism.…”

Section: Discussionmentioning

confidence: 98%

Requirement for CD8+ T cells in the development of airway hyperresponsiveness in a marine model of airway sensitization.

Hamelmann

Oshiba

Paluh

et al. 1996

The Journal of Experimental Medicine

186

118

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SummaryTo study the role ofCD8 + T cells in allergic sensitization, we examined the effects of in vivo depletion ofCD8 + T cells prior to sensitization on IgE production, immediate type cutaneous hypersensitivity and development of altered airway responsiveness. BALB/c mice were thymectomized and treated with anti-CD8 antibody resulting in depletion of CD8 + T cells (< 1%) in spleen and lymphoid tissues. In these mice, sensitization to ovalbumin (OVA) via the airways still resulted in IgE anti-OVA responses and immediate cutaneous reactions to OVA, but the animals were unable to develop airway hyperresponsiveness, eosinophil infiltration of the lung parenchyma, or IL-5 production in the local lymph nodes of the airway. Transfer of CD8 + T cells from naive animals during sensitization (on day 8 of the 10-d protocol) fully restored the ability to develop airway hyperresponsiveness and this was accompanied by IL-5 production and eosinophil accumulation in the lung. These data indicate a critical role for CD8 + T cells in the production of IL-5 and the development of altered airway responsiveness after antigen sensitization through the airways.

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Section: Discussionmentioning

confidence: 98%

Requirement for CD8+ T cells in the development of airway hyperresponsiveness in a marine model of airway sensitization.

Hamelmann

Oshiba

Paluh

et al. 1996

The Journal of Experimental Medicine

186

118

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“…36 In general, however, CD8 + cells appear to play a down-regulatory role with respect to the induction of IgE 37 and many reports suggest that CD4 + cells are the sole source of type 2 cytokines in cells derived from patients with atopic asthma or rhinitis.…”

mentioning

confidence: 98%

Interleukins 5 and 13 characterize immune responses to respiratory sensitizing acid anhydrides

Dearman

Filby

Humphreys

et al. 2002

J of Applied Toxicology

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There is some debate regarding whether occupational asthma induced by respiratory sensitizing acid anhydrides is mediated by the induction of T helper (Th) 2-type responses and the production of IgE, with failure to detect specific IgE antibody in some symptomatic patients. In the current investigations, cytokine secretion profiles induced in draining lymph node cells (LNC) by topical application to BALB/c strain mice of trimellitic anhydride (TMA), phthalic anhydride (PA) and maleic anhydride (MA) have been examined. Responses were compared with those induced by exposure to 2,4-dinitrochlorobenzene (DNCB), a contact allergen that lacks respiratory sensitizing potential. Exposure to all three acid anhydrides stimulated vigorous expression of interleukin (IL)-5, IL-10 and IL-13 but relatively low levels of the type 1 cytokines interferon-gamma (IFN-gamma) and IL-12. In addition, TMA-activated LNC expressed high levels of mitogen-inducible IL-4 whereas MA and PA displayed a lesser potential to elaborate this cytokine. The DNCB-stimulated LNC exhibited the converse type 1 phenotype of cytokine expression. The CD4(+) Th2 cells were the primary source of type 2 cytokines. Respiratory sensitizing acid anhydrides induce a predominantly Th2 cytokine phenotype, including the expression of IL-5 and IL-13, cytokines which in the presence of only very low levels of IL-4 may provide for an IgE-independent mechanism for the development of chemical respiratory allergy. These data provide additional support for the use of cytokine secretion profiling for the prospective identification of chemical respiratory allergens.

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“…CD4+ T cells can be subdivided according to the cyto kines they secrete [1] but there have been very few system atic studies of CD8+ T cell cytokine secretion [2], CD8+ T cells play an essential role in the clearance of virally infect ed cells, induction o f immunity to parasite infection and regulation of IgE production [3,4], CD8+ T cells are report ed to be major interferon (IFN)-y-producing cells and poor producers o f interleukin (IL)-4 [5,6]. The aim of this study was to systematically investigate IL-4 and IFN-y-production from highly purified human CD8+ T cells using a num ber of different stimuli.…”

Section: Introductionmentioning

confidence: 99%

Cytokine Production by Highly Purified Human CD8+ T Cells

Richards²,

Noble³

et al. 1995

Int Arch Allergy Immunol

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We have systematically investigated the capacity of highly purified human peripheral CD8+ T cells to produce interleukin (IL)-4 and interferon (IFN)-γ when triggered by different stimuli. CD8+ T cells were isolated from peripheral blood by positive selection to > 99% purity and stimulated with one of three different stimuli: phytohaemagglutinin (PHA) and IL-2, phorbol myristate acetate (PMA) and ionomycin, and plate-bound anti CD3 and PMA. On their own, ionomycin and IL-2 failed to stimulate significant CD8+ T cell proliferation while PHA, plate-bound anti-CD3 and PMA induced weak proliferation. A combination of PHA and IL-2, PMA and ionomycin, or plate-bound anti-CD3 and PMA all induced vigorous CD8+ T cell proliferation. IFN-γ was produced following all three stimuli, but was greatest from cells cultured with PMA and ionomycin. However, IL-4 secretion was only detected in cell cultures stimulated with PMA and ionomycin. These results indicate that, with sufficient stimulation, human CD8+ T cells have the potential to produce Th2 as well as Th1 cytokines.

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CD8⁺ T cells in allergy

Cited by 13 publications

References 92 publications

Requirement for CD8+ T cells in the development of airway hyperresponsiveness in a marine model of airway sensitization.

Requirement for CD8+ T cells in the development of airway hyperresponsiveness in a marine model of airway sensitization.

Interleukins 5 and 13 characterize immune responses to respiratory sensitizing acid anhydrides

Cytokine Production by Highly Purified Human CD8+ T Cells

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CD8+ T cells in allergy

Cited by 13 publications

References 92 publications

Requirement for CD8+ T cells in the development of airway hyperresponsiveness in a marine model of airway sensitization.

Requirement for CD8+ T cells in the development of airway hyperresponsiveness in a marine model of airway sensitization.

Interleukins 5 and 13 characterize immune responses to respiratory sensitizing acid anhydrides

Cytokine Production by Highly Purified Human CD8+ T Cells

Contact Info

Product

Resources

About

CD8⁺ T cells in allergy