The CD4/CD8 ratio in BAL fluid is highly variable in sarcoidosis

Kantrow, Stephen P.; Meyer, Keith C.; Kidd, Pamela; Raghu, Ganesh

doi:10.1183/09031936.97.10122716

Cited by 130 publications

(85 citation statements)

References 43 publications

(45 reference statements)

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“…Since the 1980s, several studies analysing the role of the percentage of BALF lymphocytes and the CD4/CD8 ratio have been performed with diverse results [4][5][6][7]. Since the late 1990s, however, there has been increasing evidence that neutrophilic alveolitis may play an important role in the outcome of sarcoidosis.…”

mentioning

confidence: 99%

Bronchoalveolar and serological parameters reflecting the severity of sarcoidosis

Ziegenhagen

Rothe²,

Schlaak³

et al. 2003

Eur Respir J

186

129

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The aim of the present study was to determine which bronchoalveolar lavage fluid (BALF) and serological parameters reflect the severity of newly diagnosed pulmonary sarcoidosis.Seventy-four previously untreated sarcoid patients were categorised into three groups: 10 patients with Löfgren9s syndrome, 51 patients with stable disease and 13 patients with progressing disease requiring systemic steroid treatment.Total BALF cell count, percentage of alveolar lymphocytes and lymphocyte CD4/ CD8 ratio were not associated with severity of disease. Interestingly, a significant increase in percentages of BALF neutrophils (5.2¡1.1%) and eosinophils (1.7¡0.6%) was observed in sarcoid patients with progressing disease. Elevated percentages of these two cell types were the only BALF parameters associated with a more frequent necessity for systemic steroid therapy. This association between an elevated percentage of BALF neutrophils and the necessity for steroid treatment was observed in advanced as well as early sarcoidosis (radiological types I and II). Serum levels of soluble interleukin-2 receptor and neopterin were significantly elevated in progressing disease compared to stable disease or Löfgren9s syndrome.The present results demonstrate that increased percentages of neutrophils (w3.0%) and eosinophils (w1%) in bronchoalveolar lavage fluid from newly diagnosed pulmonary sarcoidosis is associated with a significantly higher risk of necessity for steroid therapy and may be helpful markers of progressive disease. Furthermore, of the serological parameters investigated, only serum levels of soluble interleukin-2 receptor and neopterin were associated with disease severity. Eur Respir J 2003; 21: 407-413.

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mentioning

confidence: 99%

Bronchoalveolar and serological parameters reflecting the severity of sarcoidosis

Ziegenhagen

Rothe²,

Schlaak³

et al. 2003

Eur Respir J

186

129

View full text Add to dashboard Cite

show abstract

“…In addition, it is known that the differentiation of Tcells is closely related to the cytokines (Huang et al, 2014) and many cytokines are secreted by T-cells (Scott, 1993). The CD4+/CD8+ ratio can be used to provide a convenient standard for changes in cellular immune status during disease, nutritional stress, and auto-immune problems (Kantrow et al, 1997). In the present study, the CD4+/CD8+ ratio in the AFB 1 group showed a decreased tendency compared with the control group, but without apparent difference (p> 0.05) (Table 2) in the AFB 1 group during the experiment.…”

Section: Methodsmentioning

confidence: 99%

Short communication: Inhibitory effects of dietary aflatoxin B1 on cytokines expression and T-cell subsets in the cecal tonsil of broiler chickens

Liu

Jiang

Fang

et al. 2016

Span. j. agric. res.

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Aﬂatoxin B1 (AFB1) is the most toxic form among the mycotoxins. Cytokines are important mediators of the immune system. T-cell subsets play a crucial role in cell-mediated immunity. The aim of present study was to evaluate the effects of dietary AFB1 on the cytokines expression and T-cell subsets in the cecal tonsil of broiler chickens throughout a 21-day experimental period. One hundred and fifty six one-day-old broiler chickens were randomly divided into control group (0 mg AFB1/kg feed) and AFB1 group (0.6 mg pure AFB1/kg feed). At 7, 14 and 21 days of age, the levels of seven cytokines (IL-2, IL-4, IL-6, IL-10, IL-17, IFN-γ and TNF-α) mRNA expression as well as the proportions of T-cell subsets (CD3+, CD3+CD4+, CD3+CD8+) by qRT-PCR and flow cytometry methods were assessed in the cecal tonsils. The levels of the seven cytokines mRNA expression and the percentages of T-cell subsets significantly decreased at 14 and 21 days of age in the AFB1 group compared with the control group. However, the CD4+/CD8+ ratio was not significantly changed. These results demonstrate that 0.6 mg/kg AFB1 dietary exposure reduced the levels of cytokines mRNA expression and the percentages of T-cell subsets in the cecal tonsils of broiler chickens, suggesting that the cell-mediated immunity of cecal tonsils might be impaired in broilers.

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“…Several prospective clinical trials have confirmed the feasibility, safety and efficacy of SBRT, consistently reporting local control rates of 80-95%, comparable to surgical resection [1][2][3], although assessment of response is more complicated than it is following surgery [3]. Radiographic changes following SBRT differ from those following conventional RT, suggesting a unique histological response, and characterisation of these changes is a clinical challenge.…”

Section: To the Editorsmentioning

confidence: 99%

“…Although BAL lymphocytosis is not a universal finding in sarcoidosis [2], the aforementioned studies included only patients with alveolar lymphocytosis. Among our sarcoidosis patients, five (29%) out of 17 patients had a lymphocyte percentage ,10%.…”

Section: To the Editorsmentioning

confidence: 99%

See 1 more Smart Citation

Value of s-ACE, BAL lymphocytosis, and CD4+/CD8+ and CD103+CD4+/CD4+ T-cell ratios in diagnosis of sarcoidosis

Hyldgaard¹,

Kaae²,

Riddervold³

et al. 2012

Eur Respir J

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The CD4/CD8 ratio in BAL fluid is highly variable in sarcoidosis

Cited by 130 publications

References 43 publications

Bronchoalveolar and serological parameters reflecting the severity of sarcoidosis

Bronchoalveolar and serological parameters reflecting the severity of sarcoidosis

Short communication: Inhibitory effects of dietary aflatoxin B1 on cytokines expression and T-cell subsets in the cecal tonsil of broiler chickens

Value of s-ACE, BAL lymphocytosis, and CD4+/CD8+ and CD103+CD4+/CD4+ T-cell ratios in diagnosis of sarcoidosis

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