CD8+CD28− cells and CD4+CD25+ regulatory T cells in the peripheral blood of advanced stage lung cancer patients

Karagöz, Bülent; Bilgi, Oğuz; Gümüş, Mahmut; Erikçi, Alev Akyol; Sayan, Özkan; Türken, Orhan; Kandemir, Emin Gökhan; Öztürk, Ahmet; Yaylacı, Mustafa

doi:10.1007/s12032-008-9165-9

Cited by 72 publications

(47 citation statements)

References 17 publications

(15 reference statements)

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“…Their increase is associated with poor prognosis in melanoma [9]. Treg cell percentage of the patient (2.4% in CD4+ lymphocytes) was lower than reported range of melanoma patients (4.9-16%) and data of our previous lung cancer study [10]. This may be one of the explanations of long durable response.…”

Section: Discussioncontrasting

confidence: 50%

Long term survival with the combination of interferon and chemotherapy in metastatic melanoma

Karagöz

Bilgi

Ozgun

et al. 2015

Journal of the Egyptian National Cancer Institute

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The prognosis of metastatic melanoma is poor. Pre-targeted treatment era, the combination of interferon-α (IF-α) plus chemotherapy had been used and have generally short response duration. Herein, we present a metastatic melanoma case that achieved long-term durable complete response (CR) IF-α plus chemotherapy and IF-α maintenance therapy and had lower Regulatory T (Treg) cells. A fifty-year old woman was admitted to the hospital with metastatic melanoma. Lactate dehydrogenase (LDH) level was 660U/L. The percentage of CD4+CD25+ Treg cells was 2.4% in CD4+ lymphocytes. The IF-α plus chemotherapy and IF-α maintenance were administered. After six courses of chemotherapy, CR was achieved. Vitiligo and hypothyroidism occurred. The patient has remained in CR for approximately 7 years until second pleural metastases were detected and death. The patient has positive prognostic factors such as induction of autoimmunity, small tumor volume, mild elevated LDH level, and lower Treg cell percentage. She survived long term with CR after IF-α treatment with concurrent chemotherapy and maintenance. IF-α plus chemotherapy may be a treatment option for metastatic melanoma in selected cases who cannot reach new targeted drugs.

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Section: Discussioncontrasting

confidence: 50%

Long term survival with the combination of interferon and chemotherapy in metastatic melanoma

Karagöz

Bilgi

Ozgun

et al. 2015

Journal of the Egyptian National Cancer Institute

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“…CD8 + CD28 − T cells are among these T lymphocytes which are a subset of suppressor T cells that mediate suppression in a cell contact-dependent fashion and is dependent on antigen-presenting cells (APCs) (Cortesini et al 2001;Dhodapkar and Steinman 2002;Najafian et al 2003;Vescovini et al 2004). CD8 + CD28 − T suppressor cells are a typical example of Foxp3 − Tregs (Fenoglio et al 2008;Strioga et al 2011), which have been linked to age-related decline of immune functions (Simone et al 2008;Weng et al 2009), autoimmune disease (Tulunay et al 2008), cancer (Karagoz et al 2010), and transplantation (Colovai et al 2003;Renner et al 2010). However, little is known about this cell subset in schistosomiasis.…”

Section: Introductionmentioning

confidence: 99%

The expression of molecule CD28 and CD38 on CD4+/CD8+ T lymphocytes in thymus and spleen elicited by Schistosoma japonicum infection in mice model

Song

et al. 2015

Parasitol Res

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Schistosomiasis caused by human schistosomes such as Schistosoma japonicum (S. japonicum) is considered as an immune-related disease. It was demonstrated that specific cytokine antibodies' response elicited by S. japonicum infection was gradually downregulated with the progress of the disease, resulting in a Th1/Th2 polarization and suppression of immune response. CD28 (cluster of differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival, and CD38 is an activating marker of T lymphocyte with high expression in many acute or chronic infections. The immune signature of CD28null T cells in the peripheral circulation associates with chronic inflammation in many diseases, such as HIV and CMV infection. In the thymus, CD28 expression on developing thymocytes appears to play a role for their selection, and it synergizes with CD38 to induce apoptosis of DP (double-positive) thymocytes. Few reports about CD28 and CD38 have been published in schistosomiasis. Here, we investigated the dynamic patterns of the expression of molecules CD28 and CD38 on CD4(+)/CD8(+) T lymphocytes of the thymus and spleen in mice model with S. japonicum infection. Our data indicated that at an early period of infection, the frequency of CD8(+)CD28(-) T cell in the spleen decreased significantly, but higher at chronic infection than that in control. However, it demonstrated an increasing trend in the thymus with the progression of infection. The frequency of CD4(+)CD28(-) T cells increased from acute infection in the thymus, while from chronic infection in the spleen. The expression of CD38 on CD8(+) T cells began to increase at 4 weeks post infection both in the thymus and spleen; its elevated expression on CD4(+) T cells emerged at 6 weeks post infection in the thymus and at 10 weeks post infection in the spleen. Praziquantel (PZQ) treatment could partially restore the frequency of CD28(+) T cell of CD4(+) T cells and CD38(+) T cell of CD8(+)/CD4(+) T cells in the spleen and CD38(+) T cell in the thymus. We hypothesized that the reactivation of S. japonicum infection may trigger expansion of CD28(-) T cells and hence mediate systemic inflammation. We speculated that CD8(+)CD28(-) T cell might be involved in immune modulation and CD8(+)CD28(-) T cell may be a crucial part in pathogenesis, which can provide further knowledge of the sophisticated mechanism of immuno-downregulation in schistosomiasis and potential treatment target.

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“…The primary function of these lymphocytes is induction of tolerance to helper T cells during APC differentiation (12,18). An increase in circulating CD8+CD28− cells was observed in patients with infectious diseases, after organ transplantation, in certain neoplastic disorders, and in elderly patients (13,14,19,20). Disruption of production and function of these lymphocytes was observed in autoimmune disorders, for example, systemic lupus erythematosus, scleroderma, and multiple sclerosis (13,21).…”

Section: Discussionmentioning

confidence: 99%

CD8+CD28− Lymphocytes in Peripheral Blood and Serum Concentrations of Soluble Interleukin 6 Receptor are Increased in Patients with Graves’ Orbitopathy and Correlate with Disease Activity

et al. 2012

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CD8+CD28− cells and CD4+CD25+ regulatory T cells in the peripheral blood of advanced stage lung cancer patients

Abstract: These findings may reflect the possibility of tumor-induced immunosuppression and they should be complemented with further studies.

Cited by 72 publications

References 17 publications

Long term survival with the combination of interferon and chemotherapy in metastatic melanoma

Long term survival with the combination of interferon and chemotherapy in metastatic melanoma

The expression of molecule CD28 and CD38 on CD4+/CD8+ T lymphocytes in thymus and spleen elicited by Schistosoma japonicum infection in mice model

CD8+CD28− Lymphocytes in Peripheral Blood and Serum Concentrations of Soluble Interleukin 6 Receptor are Increased in Patients with Graves’ Orbitopathy and Correlate with Disease Activity

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