CD8+CD28− Lymphocytes in Peripheral Blood and Serum Concentrations of Soluble Interleukin 6 Receptor are Increased in Patients with Graves’ Orbitopathy and Correlate with Disease Activity

Słowik, Mirosław; Urbaniak-Kujda, Donata; Bohdanowicz-Pawlak, Anna; Kapelko-Słowik, Katarzyna; Dybko, Jarosław; Wołowiec, Dariusz; Jaźwiec, Bożena; Daroszewski, Jacek

doi:10.3109/07435800.2011.635622

Cited by 37 publications

(28 citation statements)

References 17 publications

(21 reference statements)

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“…Although CD8 + Ts cells play a vital role in immune tolerance (Najafian et al, 2003;Filaci et al, 2007), there are conflicting results regarding their abnormality in autoimmune diseases (Tulunay et al, 2008;Mikulkova et al, 2010;Slowik et al, 2012;Ceeraz et al, 2013;Dai et al, 2013;Yarde et al, 2014). What is the reason for this contradiction?…”

Section: Discussionmentioning

confidence: 99%

Numerical and functional defects in CD8⁺CD28⁻ T‐suppressor lymphocytes from patients with primary immune thrombocytopenia

Hao

Zhang

et al. 2017

Br J Haematol

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Primary immune thrombocytopenia (ITP) is an acquired autoimmune disorder, and loss of immune tolerance has been implicated in ITP pathogenesis. CD8 CD28 suppressor (Ts) cells have an immunosuppression function and are involved in several autoimmune disorders. However, the role of Ts cells in ITP is currently not clear. Here, flow cytometry was used to detect the CD8 CD28 CD127 proportion, which was decreased in active ITP patients compared with that of controls. Function analysis showed that immunosuppression of CD8 CD28 Ts cells in ITP patients was impaired. Mechanistic studies have shown that CD8 CD28 Ts cells from controls can downregulate CD80 and upregulate LILRB4 (ITL3) and LILRB2 (ILT4) expression on CD14 monocytes, whereas these abilities were not found in Ts cells from ITP patients. Furthermore, Inducible T-cell costimulatory (ICOS) expression on the Ts cell surface after activation was decreased whereas programmed death 1 and interleukin 10 expression was not changed in ITP patients compared with those of controls. In summary, the down-regulated quantity and function of Ts cells in active patients indicated that a Ts defect was involved in ITP. Moreover, decreased ICOS expression and the loss of the ability to regulate co-stimulator expression on antigen-presenting cells partly explained the defective Ts-mediated suppression.

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Section: Discussionmentioning

confidence: 99%

Numerical and functional defects in CD8⁺CD28⁻ T‐suppressor lymphocytes from patients with primary immune thrombocytopenia

Hao

Zhang

et al. 2017

Br J Haematol

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“…Moreover, Slowik et al . proved that in patients with thyroid eye disease the IL‐6 and soluble IL‐6 receptor levels were significantly higher than in normal controls. They also showed that after efficient treatment soluble IL‐6 receptor levels decreased in thyroid eye disease patients.…”

Section: Il‐6 Blockade In Ocular Inflammatory Diseasesmentioning

confidence: 94%

Interleukin-6 blockade in ocular inflammatory diseases

Mesquida

Leszczynska

Llorenç

et al. 2014

Clinical and Experimental Immunology

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SummaryInterleukin-6 (IL-6) is a key cytokine featuring redundancy and pleiotropic activity. It plays a central role in host defence against environmental stress such as infection and injury. Dysregulated, persistent interleukin (IL)-6 production has been implicated in the development of various autoimmune, chronic inflammatory diseases and even cancers. Significant elevation of IL-6 has been found in ocular fluids derived from refractory/chronic uveitis patients. In experimental autoimmune uveitis models with IL-6 knock-out mice, IL-6 has shown to be essential for inducing inflammation. IL-6 blockade can suppress acute T helper type 17 (Th17) responses via its differentiation and, importantly, can ameliorate chronic inflammation. Tocilizumab, a recombinant humanized anti-IL-6 receptor antibody, has been shown to be effective in several autoimmune diseases, including uveitis. Herein, we discuss the basic biology of IL-6 and its role in development of autoimmune conditions, focusing particularly on non-infectious uveitis. It also provides an overview of efficacy and safety of tocilizumab therapy for ocular inflammatory diseases.

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“…IL-6 усиливает экспрессию TSHR на поверхности орбитальных фибробластов, а так же ускоряет дифференцировку и выработку аутоантител к данному рецептору В-лимфоцитами [20]. Повышение рецепторов к IL-6 (IL-6R) имеет прямые корреляционные связи с активностью ЭОП [21]. IL-1β стимулирует синтез гиалуроновой кислоты фибробластами орбиты и ускоряет адипогенез [22].…”

Section: иммунологические аспекты патогенеза эопunclassified

Morphofunctional characteristics and immunological regulation of the orbital fibroblasts function in endocrine ophthalmopathy

et al. 2019

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НАЗВАНИЕ СТАТЬИМорфофункциональная характеристика и иммунологическая регуляция функции орбитальных фибробластов при эндокринной офтальмопатии АВТОРЫ Е.С. Таскина *, С.В. Харинцева ОРГАНИЗАЦИИ ФГБОУ ВО Читинская государственная медицинская академия, Чита, Россия РЕЗЮМЕ Эндокринная офтальмопатия (ЭОП) -это хроническое заболевание, характеризующееся прогрессирующим аутоиммунным воспалением мягких ретробульбарных тканей. В патогенезе инфильтративного процесса и фиброзирования экстраокулярных мышц и/или ретробульбарной клетчатки важное значение имеют орбитальные фибробласты, обладающие уникальными морфофункциональными свойствами. Они, в отличие от фибробластов других локализаций, имеют не мезодермальное, а нейро-экдодермальное происхождение. В обзоре рассматриваются иммунологические аспекты регулирования функции данных клеток в разные фазы активности заболевания. Межклеточное взаимодействие с Т-лимфоцитами (CD40-CD154) приводит к активации орбитальных фибробластов с усилением экспрессии патологических рецепторов к тиреотропному гормону, а также продукции компонентов межклеточного матрикса, молекул адгезии, ростовых факторов, цитокинов и простагландинов. Дана подробная морфофункциональная характеристика отдельных субпопуляций фибробластов орбиты и механизмы регуляции их трансдифференцировки в адипоциты и миофибробласты. Представлен анализ литературных данных по влиянию T-хелперов 17 типа на функциональную активность Thy1+/Thy1-(CD90+/CD90) орбитальных фибробластов. Отмечена важность дальнейшего изучения особенностей фибробластов орбиты при ЭОП и их межклеточного взаимодействия с различными иммунными клетками, что, возможно, сможет раскрыть новые патогенетические механизмы изучаемой патологии. Ключевые слова: эндокринная офтальмопатия, патогенез, орбитальные фибробласты. TITLE Morphofunctional characteristics and immunological regulation of the orbital fibroblasts function in endocrine ophthalmopathy AUTHORS ABSTRACT Clinical and experimental thyroidology.Endocrine ophthalmopathy (EOP) is a chronic disease characterized by progressive autoimmune inflammation of the soft retrobulbar tissues in thyroid dysfunction. The orbital fibroblasts with their unique morphofunctional properties are very important in the pathogenesis of the infiltrative process and fibrosis of the extraocular muscles and / or retrobulbar tissue, They, unlike other localization fibroblasts, have not mesodermal, but neuro-ectodermal origin. The review acquaints with the immunological aspects of the regulation of these cells in different activity phases of disease. Intercellular interaction with T-lymphocytes (CD40-CD154) leads to orbital fibroblasts activation with increased expression of pathological receptors for thyroid-stimulating hormone, as well as production of intercellular matrix components, adhesion molecules, growth factors, cytokines and prostaglandins. Detailed morphofunctional characteristics of the orbit fibroblast subpopulations and mechanisms regulating their transdifferentiation into adipocytes and myofibroblasts are given. The analys...

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CD8+CD28− Lymphocytes in Peripheral Blood and Serum Concentrations of Soluble Interleukin 6 Receptor are Increased in Patients with Graves’ Orbitopathy and Correlate with Disease Activity

Cited by 37 publications

References 17 publications

Numerical and functional defects in CD8⁺CD28⁻ T‐suppressor lymphocytes from patients with primary immune thrombocytopenia

Numerical and functional defects in CD8⁺CD28⁻ T‐suppressor lymphocytes from patients with primary immune thrombocytopenia

Interleukin-6 blockade in ocular inflammatory diseases

Morphofunctional characteristics and immunological regulation of the orbital fibroblasts function in endocrine ophthalmopathy

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CD8+CD28− Lymphocytes in Peripheral Blood and Serum Concentrations of Soluble Interleukin 6 Receptor are Increased in Patients with Graves’ Orbitopathy and Correlate with Disease Activity

Cited by 37 publications

References 17 publications

Numerical and functional defects in CD8+CD28− T‐suppressor lymphocytes from patients with primary immune thrombocytopenia

Numerical and functional defects in CD8+CD28− T‐suppressor lymphocytes from patients with primary immune thrombocytopenia

Interleukin-6 blockade in ocular inflammatory diseases

Morphofunctional characteristics and immunological regulation of the orbital fibroblasts function in endocrine ophthalmopathy

Contact Info

Product

Resources

About

Numerical and functional defects in CD8⁺CD28⁻ T‐suppressor lymphocytes from patients with primary immune thrombocytopenia

Numerical and functional defects in CD8⁺CD28⁻ T‐suppressor lymphocytes from patients with primary immune thrombocytopenia