CD57⁺ cells in radicular cyst

Abstract

As the expression of CD57 is indicative of immunosuppression, it may constitute a negative immunomodulator of RC's epithelium growth. Further studies are necessary to understand the importance of this cell to the biological activity or inactivity of RC's epithelium development.

Histopathological study of radicular cysts diagnosed in a Brazilian population

“…Chronic inflammatory infiltrate, multinucleated giant cells and neutrophils were also observed in the cysts. These features are comparable to those described previously (1,5).…”

“…The criterion used to name the lesions of radicular cyst was a well-delimited cavity lined by stratified squamous epithelium defined by Nair (1). The inflammatory infiltrate was classified as discrete, moderate or intense, and the epithelium was classified as atrophic (2 to 10 cell layers) or hyperplastic (>10 cell layers) (5). Furthermore, other morphological features as apoptosis, mucosal cells, odontogenic epithelial remnants, eosinophilic bodies of Rushton, foamy macrophages, cholesterol crystals, and others were also included.…”

Correlation between inflammatory infiltrate and epithelial lining in 214 cases of periapical cysts

“…18 The majority of the lesions evaluated in our study had atrophic epithelial lining, which was associated with moderate inflammatory infiltrate in the cystic capsule (p < 0.01), with a diffuse location pattern (p = 0.03), and absence of neutrophils (p = 0.01). Nevertheless, according to Moreira et al, 18 no difference can be seen in the intensity of the infiltrate in lesions with atrophic or hyperplastic epithelium. These authors found different expression patterns of CD57, in which lesions with atrophic epithelium presented a higher percentage of CD57-positive cells.…”

Immunoexpression of vascular endothelial growth factor in periapical granulomas, radicular cysts, and residual radicular cysts

“…22,30 On quiescent lesions (atrophic epithelium), despite the presence of antigens and enzymes able to induce immunologic responses, epithelium proliferation, and bone resorption, cyst enlargement does not occur. 22 In such phases, immunosuppressor effectors 22 or apoptotic events 31 may operate to regulate cyst enlargement. Despite those reports, the present results revealed that most of the RCs and RRCs with atrophic epithelial lining present strong epithelial expression of VEGF.…”