CD44 Receptor-Targeted and Reactive Oxygen Species-Responsive H2S Donor Micelles Based on Hyaluronic Acid for the Therapy of Renal Ischemia/Reperfusion Injury
Abstract:For the therapy attenuating
renal ischemia–reperfusion (IR)
injury, a novel drug delivery system was urgently needed, which could
precisely deliver drugs to the pathological renal tissue. Here, we
have prepared new nanomaterials with a reactive oxygen species (ROS)-responsive
hydrogen sulfide (H2S) donor and hyaluronic acid that targets
CD44 receptor. The novel material was synthesized and characterized
via related experiments. Then, rapamycin was loaded, which inhibited
kidney damage. In the in vitro study, w… Show more
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